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Title:
TRIPTERYGIUM WILFORDII DITERPENE LACTONE DERIVATIVES, THEIR PHARMACEUTICAL COMPOSITIONS AND THEIR APPLICATION IN INHIBITING TUMOUR OF REPRODUCTIVE SYSTEM
Document Type and Number:
WIPO Patent Application WO/2009/124460
Kind Code:
A1
Abstract:
The invention discloses Tripterygium wilfordii diterpene lactone derivatives represented by formula (1), their optical isomers and pharmaceutically acceptable salts and hydrates. The invention also provides pharmaceutical compositions and preparations comprising therapeutically effective Tripterygium wilfordii diterpene lactone derivatives represented by formula (1), their optical isomers and pharmaceutically acceptable salts and hydrates, and conventional pharmaceutical auxiliaries. The invention also discloses the application of the pharmaceutical compositions. The invention screens Tripterygium wilfordii diterpene lactone derivatives with good effect and low toxicity and makes them use in preparing medicaments for treating tumor diseases. The pharmaceutical compositions can be formulated to preparations in favor of the absorption by warm blood's tissues and apparatuses and have good application foreground in treating proliferative diseases such as tumors and so on.

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Inventors:
LI YUANCHAO (CN)
LI ZHENG (CN)
LIN LIPING (CN)
MIAO ZEHONG (CN)
REN JIN (CN)
LI CHUAN (CN)
GAN YONG (CN)
DING JIAN (CN)
FENG HUIJIN (CN)
Application Number:
PCT/CN2009/000360
Publication Date:
October 15, 2009
Filing Date:
April 02, 2009
Export Citation:
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Assignee:
SHANGHAI INST MATERIA MEDICA (CN)
LI YUANCHAO (CN)
LI ZHENG (CN)
LIN LIPING (CN)
MIAO ZEHONG (CN)
REN JIN (CN)
LI CHUAN (CN)
GAN YONG (CN)
DING JIAN (CN)
FENG HUIJIN (CN)
International Classes:
C07J73/00; A61K31/585; A61P35/00; C07J21/00; C07J33/00; C07J71/00
Foreign References:
CN101255186A2008-09-03
Attorney, Agent or Firm:
KINGSOUND & PARTNERS (Block B KingSound International Center,116 Zizhuyuan Road, Haidian District, Beijing 7, CN)
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