Title:
TUBERCULATIN ANALOGS AS ANTIVIRAL AGENTS
Document Type and Number:
WIPO Patent Application WO/2022/135136
Kind Code:
A1
Abstract:
Provided herein are tuberculatin analogs that are useful as antivirals, such as anti-HIV, anti-coronaviral, anti-Ebola viral, and anti-influenza viral agents and methods of use thereof.
Inventors:
ZHANG HONGJIE (CN)
ZHU YU (CN)
TSANG NGA YI (CN)
ZHAO YANG (CN)
ZHU YU (CN)
TSANG NGA YI (CN)
ZHAO YANG (CN)
Application Number:
PCT/CN2021/136032
Publication Date:
June 30, 2022
Filing Date:
December 07, 2021
Export Citation:
Assignee:
UNIV HONG KONG BAPTIST UNIV (CN)
International Classes:
C07D407/14; A61K31/7028; A61P31/12; A61P31/14; A61P31/16; A61P31/18
Domestic Patent References:
| WO2021229602A1 | 2021-11-18 | |||
| WO2021206309A1 | 2021-10-14 | |||
| WO2021041852A1 | 2021-03-04 | |||
| WO2021037077A1 | 2021-03-04 | |||
| WO2013019662A1 | 2013-02-07 | |||
| WO2019182947A1 | 2019-09-26 |
Other References:
STEFANIK MICHAL, STRAKOVA PETRA, HAVIERNIK JAN, MILLER ANDREW D., RUZEK DANIEL, EYER LUDEK: "Antiviral Activity of Vacuolar ATPase Blocker Diphyllin against SARS-CoV-2", MICROORGANISMS, vol. 9, no. 3, pages 471, XP055946670, DOI: 10.3390/microorganisms9030471
ASANO JUN, KAZUHIRO CHIBA, MASAHIRO TADA, TAKAO YOSHII: "Antiviral activity of lignans and their glycosides from Justicia procumbens", PHYTOCHEMISTRY, vol. 42, no. 3, 1 June 1996 (1996-06-01), pages 713 - 717, XP055924677, DOI: 10.1016/0031-9422(96)00024-6
DATABASE REGISTRY 1 December 2015 (2015-12-01), ANONYMOUS : "Naphtho[2,3-c]furan-1(3H)-one, 9-(1,3-benzodioxol-5-yl)-6,7-dimethoxy-4-(5- O-.beta.-D-xylopyranosyl-D-apio-.beta.-D-furanosyl)- (CA INDEX NAME)", XP055946777, retrieved from STN Database accession no. 1821497-29-3 (+ 1627958-97-7， 1572180-17-6， 1055038-89-5， 1054646-22-8， 881422-02-2， 464195-59-3， 408358-51-0， 303085-28-1， 303084-57-3， 220182-12-7， 177912-20-8， 133174-11-5， 133137-56-1， 133084-22-7， 133084-19-2， 90706-11-9)
CHEN HUI-WEN; CHENG JENNA XIAO; LIU MING-TSAN; KING KEVIN; PENG JU-YI; ZHANG XIN-QUAN; WANG CHING-HO; SHRESTA SUJAN; SCHOOLEY ROBE: "Inhibitory and combinatorial effect of diphyllin, a v-ATPase blocker, on influenza viruses", ANTIVIRAL RESEARCH, ELSEVIER BV, NL, vol. 99, no. 3, 29 June 2013 (2013-06-29), NL , pages 371 - 382, XP028728462, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2013.06.014
C CHANG, M LIN, S LEE, K LIU, F HSU, J LIN: "Differential inhibition of reverse transcriptase and cellular DNA polymerase-α activities by lignans isolated from Chinese herbs, Phyllanthus myrtifolius Moon, and tannins from Lonicera japonica Thunb and Castanopsis hystrix", ANTIVIRAL RESEARCH, vol. 27, no. 4, 1 August 1995 (1995-08-01), pages 367 - 374, XP055154716, ISSN: 01663542, DOI: 10.1016/0166-3542(95)00020-M
ZHANG HONG-JIE; RUMSCHLAG-BOOMS EMILY; GUAN YI-FU; LIU KANG-LUN; WANG DONG-YING; LI WAN-FEI; NGUYEN VAN HUNG; CUONG NGUYEN MANH; S: "Anti-HIV diphyllin glycosides fromJusticia gendarussa", PHYTOCHEMISTRY, ELSEVIER, AMSTERDAM , NL, vol. 136, 1 January 1900 (1900-01-01), Amsterdam , NL , pages 94 - 100, XP029934524, ISSN: 0031-9422, DOI: 10.1016/j.phytochem.2017.01.005
ASANO JUN, KAZUHIRO CHIBA, MASAHIRO TADA, TAKAO YOSHII: "Antiviral activity of lignans and their glycosides from Justicia procumbens", PHYTOCHEMISTRY, vol. 42, no. 3, 1 June 1996 (1996-06-01), pages 713 - 717, XP055924677, DOI: 10.1016/0031-9422(96)00024-6
DATABASE REGISTRY 1 December 2015 (2015-12-01), ANONYMOUS : "Naphtho[2,3-c]furan-1(3H)-one, 9-(1,3-benzodioxol-5-yl)-6,7-dimethoxy-4-(5- O-.beta.-D-xylopyranosyl-D-apio-.beta.-D-furanosyl)- (CA INDEX NAME)", XP055946777, retrieved from STN Database accession no. 1821497-29-3 (+ 1627958-97-7， 1572180-17-6， 1055038-89-5， 1054646-22-8， 881422-02-2， 464195-59-3， 408358-51-0， 303085-28-1， 303084-57-3， 220182-12-7， 177912-20-8， 133174-11-5， 133137-56-1， 133084-22-7， 133084-19-2， 90706-11-9)
CHEN HUI-WEN; CHENG JENNA XIAO; LIU MING-TSAN; KING KEVIN; PENG JU-YI; ZHANG XIN-QUAN; WANG CHING-HO; SHRESTA SUJAN; SCHOOLEY ROBE: "Inhibitory and combinatorial effect of diphyllin, a v-ATPase blocker, on influenza viruses", ANTIVIRAL RESEARCH, ELSEVIER BV, NL, vol. 99, no. 3, 29 June 2013 (2013-06-29), NL , pages 371 - 382, XP028728462, ISSN: 0166-3542, DOI: 10.1016/j.antiviral.2013.06.014
C CHANG, M LIN, S LEE, K LIU, F HSU, J LIN: "Differential inhibition of reverse transcriptase and cellular DNA polymerase-α activities by lignans isolated from Chinese herbs, Phyllanthus myrtifolius Moon, and tannins from Lonicera japonica Thunb and Castanopsis hystrix", ANTIVIRAL RESEARCH, vol. 27, no. 4, 1 August 1995 (1995-08-01), pages 367 - 374, XP055154716, ISSN: 01663542, DOI: 10.1016/0166-3542(95)00020-M
ZHANG HONG-JIE; RUMSCHLAG-BOOMS EMILY; GUAN YI-FU; LIU KANG-LUN; WANG DONG-YING; LI WAN-FEI; NGUYEN VAN HUNG; CUONG NGUYEN MANH; S: "Anti-HIV diphyllin glycosides fromJusticia gendarussa", PHYTOCHEMISTRY, ELSEVIER, AMSTERDAM , NL, vol. 136, 1 January 1900 (1900-01-01), Amsterdam , NL , pages 94 - 100, XP029934524, ISSN: 0031-9422, DOI: 10.1016/j.phytochem.2017.01.005
Attorney, Agent or Firm:
BEIJING PAT SF INTELLECTUAL PROPERTY AGENCY CO. LTD (CN)
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