Title:
TUMOR-SPECIFIC POLYPEPTIDE SEQUENCE AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/087839
Kind Code:
A1
Abstract:
Provided are a tumor-specific polypeptide sequence and an application thereof. The polypeptide comprises at least any polypeptide in a first peptide group, and can optionally comprise at least any polypeptide in a second peptide group. The first peptide group comprises polypeptides having the sequences shown in SEQ ID NO: 1 to SEQ ID NO: 5; the second peptide group comprises derived peptides having the sequences shown in SEQ ID NO: 1 to SEQ ID NO: 5. The derived peptides comprise front, middle and back peptide segments connected in sequence. The middle peptide segment has at least 80% homology with the sequences shown in SEQ ID NO:1 to SEQ ID NO:5, and the sum of the lengths of the front and back peptide segments is 14-16 amino acids. Also provided are an isolated nucleic acid, a construct, an expression vector, a pharmaceutical composition, an antigen presenting cell, an immune effector cell, a tumor vaccine, and use of the polypeptide in the preparation of a drug for preventing or treating a tumor and a method for treating a tumor patient.
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Inventors:
QIU SI (CN)
LI BO (CN)
LI YOUPING (CN)
ZHANG LE (CN)
LI BO (CN)
LI YOUPING (CN)
ZHANG LE (CN)
Application Number:
PCT/CN2019/116164
Publication Date:
May 14, 2021
Filing Date:
November 07, 2019
Export Citation:
Assignee:
GENOIMMUNE THERAPEUTICS CO LTD (CN)
International Classes:
C07K14/47; A61K38/10; C12N5/10
Domestic Patent References:
| WO2007039109A1 | 2007-04-12 | |||
| WO2007062844A1 | 2007-06-07 | |||
| WO2014193999A2 | 2014-12-04 |
Foreign References:
| CN107750278A | 2018-03-02 | |||
| CN110272874A | 2019-09-24 | |||
| US20050226888A1 | 2005-10-13 |
Other References:
LIANG ZHAODUAN, QIN LILI, CHEN LEI, LI WENHUI, CHEN CHAO, HUANG YALING, ZHANG LE, LIU SONGMING, QIU SI, GE YUPING, PENG WENTING, L: "The common neoantigens in colorectal cancer are predicted and validated to be presented or immunogenic", BIORXIV, 3 July 2019 (2019-07-03), XP055810590, Retrieved from the Internet DOI: 10.1101/682617
BHATIA RAKESH; GAUTAM SHAILENDRA K.; CANNON ANDREW; THOMPSON CHRISTOPHER; HALL BRADLEY R.; AITHAL ABHIJIT; BANERJEE KASTURI; JAIN : "Cancer-associated mucins: role in immune modulation and metastasis", CANCER METASTASIS., KLUWER ACADEMIC PUBLISHERS, DORDRECHT., NL, vol. 38, no. 1, 8 January 2019 (2019-01-08), NL, pages 223 - 236, XP036833426, ISSN: 0167-7659, DOI: 10.1007/s10555-018-09775-0
BHATIA RAKESH; GAUTAM SHAILENDRA K.; CANNON ANDREW; THOMPSON CHRISTOPHER; HALL BRADLEY R.; AITHAL ABHIJIT; BANERJEE KASTURI; JAIN : "Cancer-associated mucins: role in immune modulation and metastasis", CANCER METASTASIS., KLUWER ACADEMIC PUBLISHERS, DORDRECHT., NL, vol. 38, no. 1, 8 January 2019 (2019-01-08), NL, pages 223 - 236, XP036833426, ISSN: 0167-7659, DOI: 10.1007/s10555-018-09775-0
Attorney, Agent or Firm:
TSINGYIHUA INTELLECTUAL PROPERTY LLC (CN)
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