Title:
AN ULTRABRIGHT NIR-II AIEGEN FOR BIOIMAGING
Document Type and Number:
WIPO Patent Application WO/2020/239025
Kind Code:
A1
Abstract:
The present subject matter contemplates small molecule, fluorescent compounds having aggregation-induced emission (AIE) characteristics. The compounds can exhibit emission in the second near-infrared window (NIR-II) (1000 nm-1700 nm). The compounds can provide imaging for deeply located diseases with ultrahigh signal background ratio. For example, neutrophils carrying the present compounds can penetrate the brain and visualize inflammation deeply located within the brain tissue through intact scalp and skull
Inventors:
TANG BENZHONG (CN)
LIU SHUNJIE (CN)
DING DAN (CN)
LIU SHUNJIE (CN)
DING DAN (CN)
Application Number:
PCT/CN2020/092916
Publication Date:
December 03, 2020
Filing Date:
May 28, 2020
Export Citation:
Assignee:
UNIV HONG KONG SCI & TECH (CN)
International Classes:
C07D519/00; A61K31/33; A61K49/00; A61P35/00; C07D403/04; C07D409/14; C07D471/06; C07D495/22; C07D513/04; C09K11/02; C09K11/06
Domestic Patent References:
| WO2020015700A1 | 2020-01-23 | |||
| WO2014017983A1 | 2014-01-30 |
Foreign References:
| CN109336909A | 2019-02-15 | |||
| JP2018129510A | 2018-08-16 | |||
| CN103980295A | 2014-08-13 |
Other References:
LIU, SHUNJIE ET AL: "Constitutional isomerization enables ultrabright NIR-II AIEgen for brain-inflammation imaging", CHEMRXIV (2019), 6 July 2019 (2019-07-06), XP055757860, DOI: 20200805124958PX
LIU, SHUNJIE ET AL: "Molecular Motion in Aggregates: Manipulating TICT for Boosting Photothermal Theranostics", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 141, no. 13, 13 March 2019 (2019-03-13), XP055677759, DOI: 20200804151630X
LIU, SHUNJIE ET AL: "Molecular Motion in Aggregates: Manipulating TICT for Boosting Photothermal Theranostics", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 141, no. 13, 13 March 2019 (2019-03-13), XP055677759, DOI: 20200804151630X
Attorney, Agent or Firm:
TEE & HOWE INTELLECTUAL PROPERTY ATTORNEYS (CN)
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