Title:
ULTRASONIC CELL NEURO-MODULATION SYSTEM
Document Type and Number:
WIPO Patent Application WO/2022/160988
Kind Code:
A1
Abstract:
An ultrasonic cell neuro-modulation system, comprising: a cell containing apparatus (100) for containing marked cells, wherein the cell containing apparatus (100) comprises a base (110), and a light-transmitting opening is formed in the base (110); an ultrasonic stimulation apparatus (200) comprising an ultrasonic transducer (230), wherein the ultrasonic transducer (230) is used for emitting ultrasonic waves to the marked cells; and a cell imaging apparatus (300) comprising a laser light source (310), an objective lens (350) and an image collector (370), wherein the laser light source (310) emits laser light to the marked cells through the objective lens (350) and the light-transmitting opening, and the image collector (370) collects a fluorescence image of the marked cells through the objective lens (350). By means of the modulation system, neural activity of cells can be observed from a microscopic perspective, and instantaneous and continuous real-time dynamic imaging and monitoring can be performed on the cells. A new strategy is provided for ultrasonic neuro-modulation of in-vitro cell imaging, such that the system can be applied to future ultrasonic-mediated neuro-modulation more safely and effectively.
Inventors:
YAN FEI (CN)
JIANG TIANAN (CN)
XIE LITING (CN)
JIANG TIANAN (CN)
XIE LITING (CN)
Application Number:
PCT/CN2021/138063
Publication Date:
August 04, 2022
Filing Date:
December 14, 2021
Export Citation:
Assignee:
SHENZHEN INST OF ADV TECH CAS (CN)
International Classes:
G01N21/64; G01N1/28; G01N21/01
Foreign References:
| CN112945918A | 2021-06-11 | |||
| CN110140050A | 2019-08-16 | |||
| US20160138095A1 | 2016-05-19 | |||
| US20110207238A1 | 2011-08-25 | |||
| CN112156381A | 2021-01-01 |
Other References:
"Doctoral Dissertation", 1 May 2019, UNIVERSITY OF CHINESE ACADEMY OF SCIENCES (SHENZHEN INSTITUTE OF ADVANCED TECHNOLOGY, CHINESE ACADEMY OF SCIENCES), CN, article XIAOWEI HUANG: "Neurobiological Effect of Ultrasound Radiation Force", pages: 1 - 129, XP055953527
"Doctoral Dissertation", 1 June 2018, UNIVERSITY OF CHINESE ACADEMY OF SCIENCES (SHENZHEN INSTITUTE OF ADVANCED TECHNOLOGY, CHINESE ACADEMY OF SCIENCES), CN, article GUOFENG LI: "Non-invasive Ultrasound Brain Neuromodulation Methods for Small Animals", pages: 1 - 114, XP055953536
"Doctoral Dissertation", 1 June 2018, UNIVERSITY OF CHINESE ACADEMY OF SCIENCES (SHENZHEN INSTITUTE OF ADVANCED TECHNOLOGY, CHINESE ACADEMY OF SCIENCES), CN, article GUOFENG LI: "Non-invasive Ultrasound Brain Neuromodulation Methods for Small Animals", pages: 1 - 114, XP055953536
Attorney, Agent or Firm:
BEIJING ZHONG XUN TONG DA INTELLECTUAL PROPERTY AGENCY CO., LTD. (CN)
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