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Title:
α, β-UNSATURATED AMIDE COMPOUND
Document Type and Number:
WIPO Patent Application WO/2018/235926
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide an α, β-unsaturated amide compound or a pharmaceutically acceptable salt thereof or the like, which has anti-cancer activity or the like. An α, β-unsaturated amide compound represented by formula (I) and a pharmaceutically acceptable salt thereof or the like have anti-cancer activity or the like. (In the formula, A represents an optionally substituted heterocyclic diyl group; R1 represents a hydrogen atom or an optionally substituted lower alkyl group; R2 represents an optionally substituted aryl group, an optionally substituted cycloalkyl group, an optionally substituted aliphatic heterocyclic group or an optionally substituted aromatic heterocyclic group; X represents -O-, -S-, -SO2-, -NRX1- (wherein RX1 represents a hydrogen atom or a lower alkyl group), -CHRX2- (wherein RX2 represents a hydrogen atom or a hydroxy group), -CH=CH-, -CO- or -NH-CO-; and n1 and n2 may be the same or different, and each represents 0 or 1.)

Inventors:
DANJO TOMOHIRO (JP)
YAMADA HIROKI (JP)
NAKAJIMA TAKAHIRO (JP)
Application Number:
PCT/JP2018/023723
Publication Date:
December 27, 2018
Filing Date:
June 22, 2018
Export Citation:
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Assignee:
KYOWA HAKKO KIRIN CO LTD (JP)
International Classes:
C07D213/75; A61K31/335; A61K31/343; A61K31/353; A61K31/381; A61K31/423; A61K31/428; A61K31/436; A61K31/4375; A61K31/44; A61K31/4433; A61K31/444; A61K31/47; A61K31/4709; A61K31/472; A61K31/497; A61K31/501; A61K31/506; A61K31/5377; A61K31/553; A61P1/16; A61P11/00; A61P15/00; A61P35/00; C07D215/12; C07D215/14; C07D215/20; C07D215/26; C07D215/36; C07D215/38; C07D215/40; C07D217/24; C07D263/56; C07D263/57; C07D267/14; C07D277/64; C07D307/82; C07D307/86; C07D311/22; C07D311/58; C07D311/64; C07D311/68; C07D313/08; C07D333/66; C07D401/04; C07D401/12; C07D405/12; C07D413/12; C07D417/12; C07D471/04; C07D491/052
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Attorney, Agent or Firm:
NAGAI Hiroshi et al. (JP)
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