Title:
UREIDO-CONTAINING BENZIMIDAZOLE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/098671
Kind Code:
A1
Abstract:
Disclosed is an ureido-containing benzimidazole derivative, wherein the general structural formula is as shown in formula (I). Also disclosed are a method for preparing the compound and the use thereof in the preparation of anti-chronic kidney disease drugs. The present invention is an inhibitor of selective homology domain interaction protein kinase-2(HIPK2), which can simultaneously down-regulate the protein level of HIPK2, play a dual role, has an inhibitory effect on HIPK2 kinase, protein levels, and the phosphorylation level of the fibrosis signal molecule smad3 and the inflammation signal molecule IκB-α, can simultaneously regulate fibrosis and inflammatory processes, and has a good market application prospect in terms of drugs for treating chronic kidney disease.
Inventors:
LI QIANBIN (CN)
HU GAOYUN (CN)
WANG ZEYU (CN)
CHEN ZHUO (CN)
HU GAOYUN (CN)
WANG ZEYU (CN)
CHEN ZHUO (CN)
Application Number:
PCT/CN2020/129308
Publication Date:
May 27, 2021
Filing Date:
November 17, 2020
Export Citation:
Assignee:
SHIJIAZHUANG YILING PHARMACEUTICAL CO LTD (CN)
International Classes:
C07C275/18; A61K31/17; C07C275/20; A61P13/12
Domestic Patent References:
| WO2006039718A2 | 2006-04-13 |
Foreign References:
| CN1617869A | 2005-05-18 | |||
| CN1527831A | 2004-09-08 |
Attorney, Agent or Firm:
BEIJING SANYOU INTELLECTUAL PROPERTY AGENCY LTD. (CN)
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