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Title:
UREIDO SUBSTITUTED BENZOIC ACID COMPOUNDS, THEIR USE FOR NONSENSE SUPPRESSION AND THE TREATMENT OF DISEASES CAUSED BY SUCH MUTATIONS
Document Type and Number:
WIPO Patent Application WO2004009558
Kind Code:
A3
Abstract:
The invention encompasses ureido substituted benzoic acid compounds of structure (I), compositions comprising the compounds and methods for treating or preventing diseases associated with nonsense mutations of mRNA by administering these compounds or compositions.

Inventors:
WILDE RICHARD G (US)
TAKASUGI JAMES J (US)
HWANG SEONGWOO (US)
WELCH ELLEN M (US)
CHEN GUANGMING (US)
Application Number:
US0323182W
Publication Date:
April 15, 2004
Filing Date:
July 23, 2003
Export Citation:
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Assignee:
PTC THERAPEUTICS INC (US)
WILDE RICHARD G (US)
TAKASUGI JAMES J (US)
HWANG SEONGWOO (US)
WELCH ELLEN M (US)
CHEN GUANGMING (US)
International Classes:
A61K31/17; A61K31/4166; A61P35/00; C07C275/42; C07D233/32; C07D233/42; C07D233/70; C07D233/72; C07D233/78; C07D233/84; C07D285/16; C07D401/04; C07D401/10; C07D405/04; C07D405/06; C07D409/04; (IPC1-7): A61K31/17; A61K31/4166; C07D233/78; C07C275/42; C07D285/16; C07D285/06; C07D405/06; C07D233/32; C07D233/70; C07D233/84; C07D405/04; C07D403/10; C07D409/10; C07D401/10; A61P35/00
Domestic Patent References:
WO2002070494A12002-09-12
WO2000026203A12000-05-11
WO2001012188A12001-02-22
Foreign References:
US6037345A2000-03-14
EP1205478A12002-05-15
US3799969A1974-03-26
US2680730A1954-06-08
US4174398A1979-11-13
Other References:
NAKAO K ET AL: "QUANTITATIVE STRUCTURE-ACTIVITY ANALYSES OF NOVEL HYDROXYPHENYLUREADERIVATIVES AS ANTIOXIDANTS", BIOORGANIC & MEDICINAL CHEMISTRY, ELSEVIER SCIENCE LTD, GB, vol. 6, no. 6, 1998, pages 849 - 868, XP000961127, ISSN: 0968-0896
BAURES, PW; OZA, V B; PETERSON, S. A; KELLY, J W: "Synthesis and Evaluation of Inhibitors of Transthyretin Amyloid Formation Based on the Non-steroidal Anti-inflammatory Drug, Flufenamic acid", BIOORGANIC AND MEDICAL CHEMISTRY, vol. 7, 1999, pages 1339 - 1347, XP002261771
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; 1988, XP002261772, Database accession no. BRN 850669, 847575
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; 2000, XP002261773, Database accession no. BRN 8288364, 8288635, 8288314
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; 1990, XP002261774, Database accession no. BRN 3385323, 3431832
DATABASE BEILSTEIN BEILSTEIN INSTITUTE FOR ORGANIC CHEMISTRY, FRANKFURT-MAIN, DE; 1989, XP002261775, Database accession no. BRN 2142974, 2153838, 214575
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