Title:
USE OF ANNEXIN A5
Document Type and Number:
WIPO Patent Application WO/2021/037230
Kind Code:
A1
Abstract:
The present invention relates to the field of biomedicine, and provides the use of annexin A5 for the prevention and/or treatment of diseases or conditions, said diseases or conditions being selected from cerebral stroke, neurobehavioral defects, neurodegenerative diseases, nerve injury, hyperactivity of immune cells in the brain, blood-brain barrier damage, cerebral edema, increased calcium ion content, excitotoxicity, NOS over-activation, and diseases or conditions caused by at least one of the aforementioned diseases or conditions.
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Inventors:
YANG LEI (CN)
LIAN GUONING (CN)
GAO XIAOPING (CN)
ZHU LIN (CN)
WANG CHUAN (CN)
ZHU TAOTAO (CN)
WANG XINGXING (CN)
ZHUO LANG (CN)
LIAN GUONING (CN)
GAO XIAOPING (CN)
ZHU LIN (CN)
WANG CHUAN (CN)
ZHU TAOTAO (CN)
WANG XINGXING (CN)
ZHUO LANG (CN)
Application Number:
PCT/CN2020/112217
Publication Date:
March 04, 2021
Filing Date:
August 28, 2020
Export Citation:
Assignee:
SUZHOU YABAO PHARMACEUTICAL R&D CO LTD (CN)
International Classes:
A61K38/17; A61P7/00; A61P25/00
Domestic Patent References:
| WO2012136819A1 | 2012-10-11 |
Foreign References:
| CN107921068A | 2018-04-17 | |||
| CN106714814A | 2017-05-24 | |||
| CN101405017A | 2009-04-08 | |||
| CN102105594A | 2011-06-22 | |||
| CN201910815496A | 2019-08-30 |
Other References:
M L P J VAN GOOR , W L VAN HEERDE , S SCHOORMANS , S W J DIPPEL , F W G LEEBEEK: "The Annexin A5-1C/T polymorphism in ischemic stroke: a case-control study", JOURNAL OF THROMBOSIS AND HAEMOSTASIS, vol. 3, no. 1, 22 December 2004 (2004-12-22), pages 173 - 175, XP055787427, ISSN: 1538-7836, DOI: 10.1111/j.1538-7836.2004.01096.x
BAHMANI PEYMAN, SCHELLENBERGER EYK, KLOHS JAN, STEINBRINK JENS, CORDELL RYAN, ZILLE MARIETTA, MÃÂüLLER JOCHEN, HARHAUSEN DENI: "Visualization of cell death in mice with focal cerebral ischemia using fluorescent annexin A5, propidium iodide, and TUNEL staining.", JOURNAL OF CEREBRAL BLOOD FLOW & METABOLISM, vol. 31, no. 5, 19 January 2011 (2011-01-19), pages 1311 - 1320, XP055787430, ISSN: 0271-678X, DOI: 10.1038/jcbfm.2010.233
J. MOL. BIOL., vol. 223, no. 3, 1992, pages 683 - 704
JOLKKONEN JGALLAGHER NPZILLES KSIVENIUS J, BEHAV BRAIN RES, vol. 138, 2003, pages 187 - 200
BEDERSON JBPITTS LHTSUJI MNISHIMURA MCDAVIS RLBARTKOWSKI H: "Rat middle cerebral artery occlusion, evaluation of the model and development of a neurologic examination", STROKE, vol. 17, 1986, pages 472 - 476
BEDERSON JBPITTS LHGERMANO SMNISHIMURA MCDAVIS RLBARTKOWSKI HM: "Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats", STROKE, vol. 17, 1986, pages 1304 - 8
YANG YSHUAIB ALI Q: "Quantification of infarct size on focal cerebral ischemia model of rats using a simple and economical method", JNEUROSCI METHODS, vol. 84, 1998, pages 9 - 16
BAHMANI PEYMAN, SCHELLENBERGER EYK, KLOHS JAN, STEINBRINK JENS, CORDELL RYAN, ZILLE MARIETTA, MÃÂüLLER JOCHEN, HARHAUSEN DENI: "Visualization of cell death in mice with focal cerebral ischemia using fluorescent annexin A5, propidium iodide, and TUNEL staining.", JOURNAL OF CEREBRAL BLOOD FLOW & METABOLISM, vol. 31, no. 5, 19 January 2011 (2011-01-19), pages 1311 - 1320, XP055787430, ISSN: 0271-678X, DOI: 10.1038/jcbfm.2010.233
J. MOL. BIOL., vol. 223, no. 3, 1992, pages 683 - 704
JOLKKONEN JGALLAGHER NPZILLES KSIVENIUS J, BEHAV BRAIN RES, vol. 138, 2003, pages 187 - 200
BEDERSON JBPITTS LHTSUJI MNISHIMURA MCDAVIS RLBARTKOWSKI H: "Rat middle cerebral artery occlusion, evaluation of the model and development of a neurologic examination", STROKE, vol. 17, 1986, pages 472 - 476
BEDERSON JBPITTS LHGERMANO SMNISHIMURA MCDAVIS RLBARTKOWSKI HM: "Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats", STROKE, vol. 17, 1986, pages 1304 - 8
YANG YSHUAIB ALI Q: "Quantification of infarct size on focal cerebral ischemia model of rats using a simple and economical method", JNEUROSCI METHODS, vol. 84, 1998, pages 9 - 16
Attorney, Agent or Firm:
BEIJING ORIGINTELLIGENCE IP LAW FIRM (CN)
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