Title:
USE OF AZITHROMYCIN FOR THE MANUFACTURE OF A MEDICAMENT FOR TREATMENT OF NON-INFECTIVE INFLAMMATORY DISEASES
Document Type and Number:
WIPO Patent Application WO2002087596
Kind Code:
A3
Abstract:
The invention relates to the use of 9-deoxo-9-dihydro-9a-methyl-9a-aza-9a-homoerythromycin. A (generic name: azithromycin) for the therapy of neutrophil-dominated non-infective inflammatory diseases, pharmaceutical compositions containing azithromycin for enteral or parenteral administration and methods for the production of these pharmaceutical composiitons.
Inventors:
CULIC OGNJEN (HR)
PARNHAM MICHAEL (HR)
ERAKOVIC VESNA (HR)
PARNHAM MICHAEL (HR)
ERAKOVIC VESNA (HR)
Application Number:
PCT/EP2002/003984
Publication Date:
January 03, 2003
Filing Date:
April 10, 2002
Export Citation:
Assignee:
PLIVA D D (HR)
CULIC OGNJEN (HR)
PARNHAM MICHAEL (HR)
ERAKOVIC VESNA (HR)
CULIC OGNJEN (HR)
PARNHAM MICHAEL (HR)
ERAKOVIC VESNA (HR)
International Classes:
A61K9/02; A61K9/08; A61K9/10; A61K9/12; A61K9/127; A61K9/14; C07H17/00; A61K9/20; A61K9/48; A61K9/70; A61K31/7048; A61K31/7052; A61K45/00; A61K45/06; A61K47/02; A61K47/14; A61K47/26; A61K47/32; A61K47/36; A61K47/42; A61K47/46; A61P1/00; A61P1/04; A61P11/00; A61P13/12; A61P17/00; A61P17/06; A61P19/02; A61P29/00; A61P37/00; A61P37/02; (IPC1-7): A61K31/7048; A61P1/00; A61P11/00; A61P17/00; A61P29/00; A61P37/00
Domestic Patent References:
| WO1999024036A1 | 1999-05-20 | |||
| WO2000025756A2 | 2000-05-11 | |||
| WO2001000640A1 | 2001-01-04 | |||
| WO1995009601A1 | 1995-04-13 |
Foreign References:
| EP0445743A2 | 1991-09-11 | |||
| EP0467331A1 | 1992-01-22 |
Other References:
RUBIN B.K. ET AL: "Macrolide antibiotics as biological response modifiers.", CURRENT OPINION IN INVESTIGATIONAL DRUGS, (2000) 1/2 (169-172)., XP001104803
NARITA NOBUHIRO: ""Multi-effect" macrolides.", INTERNAL MEDICINE (TOKYO), vol. 39, no. 8, August 2000 (2000-08-01), pages 599 - 600, XP001104921, ISSN: 0918-2918
SCAGLIONE F ET AL: "Comparative anti-inflammatory effects of roxithromycin, azithromycin and clarithromycin.", JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, vol. 41, no. SUPPL. B, March 1998 (1998-03-01), pages 47 - 50, XP001104919, ISSN: 0305-7453
LABRO M.T. ET AL: "Immunomodulation by macrolide antibiotics.", JOURNAL OF CHEMOTHERAPY, (2001) 13/1 (3-8)., XP001104982
DATABASE MEDLINE [online] December 2000 (2000-12-01), GÓMEZ J ET AL: "[Prospective, comparative study (1994-1998) of the influence of short-term prophylactic treatment with azithromycin on patients with advanced COPD]", XP002213965, Database accession no. NLM11498704
ALTSCHULER E.L.: "Azithromycin, the multidrug-resistant protein, and cystic fibrosis [4].", LANCET, (25 APR 1998) 351/9111 (1286)., XP001105350
SETHI G.R. ET AL: "Bronchiectasis: Causes and management.", INDIAN JOURNAL OF PEDIATRICS, (2000) 67/2 (133-139)., XP001105351
WALES D. ET AL: "The anti-inflammatory effects of macrolides.", THORAX, (1999) 54/SUPPL. 2 (S58-S62)., XP001104995
SPENCER D.: "Macrolide antibiotics in diffuse panbronchiolitis and in cystic fibrosis [2].", EUROPEAN RESPIRATORY JOURNAL, (1998) 11/6 (1428)., XP001104988
DESTACHE CHRISTOPHER J ET AL: "Clinical and economic considerations in the treatment of acute exacerbations of chronic bronchitis.", JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, vol. 43, no. SUPPL. 1, March 1999 (1999-03-01), pages 107 - 113, XP001104994, ISSN: 0305-7453
FERNANDEZ-OBREGON, A. C.: "Azithromycin for the treatment of acne", INT.J. DERMATOL., vol. 39, 2000, pages 45 - 50, XP002213964
DATABASE EMBASE [online] ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL; MOMIN A. ET AL: "Reiter's syndrome - 3 case report.", XP002213966, retrieved from STN Database accession no. 1998054754
O'DELL J.R.: "Is there a role for antibiotics in the treatment of patients with rheumatoid arthritis?.", DRUGS, (1999) 57/3 (279-282)., XP001104987
GUI G. P. H. ET AL: "Two-year-outcomes analysis of Crohn's diease treated with rifabutin and macrolide antibiotics", JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, (1997), 39(3), 393-400, 47 REFS. ISSN: 0305-7453 CODEN: JACHDX, University Department of Surgery, St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, United Kingdom, XP001104989
NARITA NOBUHIRO: ""Multi-effect" macrolides.", INTERNAL MEDICINE (TOKYO), vol. 39, no. 8, August 2000 (2000-08-01), pages 599 - 600, XP001104921, ISSN: 0918-2918
SCAGLIONE F ET AL: "Comparative anti-inflammatory effects of roxithromycin, azithromycin and clarithromycin.", JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, vol. 41, no. SUPPL. B, March 1998 (1998-03-01), pages 47 - 50, XP001104919, ISSN: 0305-7453
LABRO M.T. ET AL: "Immunomodulation by macrolide antibiotics.", JOURNAL OF CHEMOTHERAPY, (2001) 13/1 (3-8)., XP001104982
DATABASE MEDLINE [online] December 2000 (2000-12-01), GÓMEZ J ET AL: "[Prospective, comparative study (1994-1998) of the influence of short-term prophylactic treatment with azithromycin on patients with advanced COPD]", XP002213965, Database accession no. NLM11498704
ALTSCHULER E.L.: "Azithromycin, the multidrug-resistant protein, and cystic fibrosis [4].", LANCET, (25 APR 1998) 351/9111 (1286)., XP001105350
SETHI G.R. ET AL: "Bronchiectasis: Causes and management.", INDIAN JOURNAL OF PEDIATRICS, (2000) 67/2 (133-139)., XP001105351
WALES D. ET AL: "The anti-inflammatory effects of macrolides.", THORAX, (1999) 54/SUPPL. 2 (S58-S62)., XP001104995
SPENCER D.: "Macrolide antibiotics in diffuse panbronchiolitis and in cystic fibrosis [2].", EUROPEAN RESPIRATORY JOURNAL, (1998) 11/6 (1428)., XP001104988
DESTACHE CHRISTOPHER J ET AL: "Clinical and economic considerations in the treatment of acute exacerbations of chronic bronchitis.", JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, vol. 43, no. SUPPL. 1, March 1999 (1999-03-01), pages 107 - 113, XP001104994, ISSN: 0305-7453
FERNANDEZ-OBREGON, A. C.: "Azithromycin for the treatment of acne", INT.J. DERMATOL., vol. 39, 2000, pages 45 - 50, XP002213964
DATABASE EMBASE [online] ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL; MOMIN A. ET AL: "Reiter's syndrome - 3 case report.", XP002213966, retrieved from STN Database accession no. 1998054754
O'DELL J.R.: "Is there a role for antibiotics in the treatment of patients with rheumatoid arthritis?.", DRUGS, (1999) 57/3 (279-282)., XP001104987
GUI G. P. H. ET AL: "Two-year-outcomes analysis of Crohn's diease treated with rifabutin and macrolide antibiotics", JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, (1997), 39(3), 393-400, 47 REFS. ISSN: 0305-7453 CODEN: JACHDX, University Department of Surgery, St George's Hospital Medical School, Cranmer Terrace, London SW17 0RE, United Kingdom, XP001104989
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