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Title:
Use of bi- and tricyclic pyridone derivates against alzheimer's disease
Document Type and Number:
WIPO Patent Application WO1998025930
Kind Code:
A3
Abstract:
The invention is concerned with the use of bi- and tricyclic pyridone compounds of the formula where A, R1, R3, R4, and R7 are described herein and of their pharmaceutically acceptable salts for the production of medicaments for the prophylaxis or treatment of illnesses which are connected with an inhibition of beta -amyloid peptide activity, especially for the treatment of Alzheimer's disease.

Inventors:
HUBER TROTTMAN GERDA (CH)
JAKOB-ROETNE ROLAND (DE)
KOLCZEWSKI SABINE (DE)
NORCROSS ROGER DAVID (CH)
WOLTERING THOMAS JOHANNES (DE)
Application Number:
PCT/EP1997/006865
Publication Date:
August 13, 1998
Filing Date:
December 09, 1997
Export Citation:
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Assignee:
HOFFMANN LA ROCHE (CH)
International Classes:
C07D455/02; C07D455/06; C07D471/14; C07D495/14; (IPC1-7): A61K31/435; C07D455/02; C07D455/06; C07D471/14; C07D495/14
Domestic Patent References:
WO1994007491A11994-04-14
WO1996025932A11996-08-29
Foreign References:
EP0183994A11986-06-11
EP0157346A21985-10-09
EP0398033A11990-11-22
EP0729749A11996-09-04
Other References:
TAKUMI IMAI ET AL.: "Effects of a novel orally-active antiallergic Drug, Quintolast (FK021) on airway clearance", NIPPON YAKURIGAKU ZASSHI, vol. 104, no. 4, 1994, pages 347 - 355, XP002068162
GRIEBEL ET AL.: "Further evidence for differences between non-selective and BZ-1 (.omega.1) selective benzodiazepine receptor ligands in murine models of " state" and "trait" anxiety", NEUROPHARMACOLOGY, vol. 35, no. 8, 1996, pages 1081 - 1091, XP002068163
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