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Title:
USE OF CERAMIDES AND LPLS IN DIAGNOSING CVD
Document Type and Number:
WIPO Patent Application WO/2017/097852
Kind Code:
A3
Abstract:
The present invention inter alia provides a method, and use thereof, of predicting CV events such as AMI, ACS, stroke, and CV death by determining the concentration of at least one ceramide of Formula I or one lysophospholipid of Formula II and/or III and at least one lysophospholipid of Formula IV, V, VI, V II and/or VIII in a biological sample and comparing those concentrations to a control. Finding an increased concentration of the at least one Formula I ceramide or Formula II and/or III lysophospholipid and a decreased concentration of the at least one Formula IV, V, VI, VII and/or VIII lysophospholipid indicates that the subject has an increased risk of developing one or more CV events. The present disclosure also provides a method, and use thereof, of diagnosing subjects suffering acute ischemia. Also provided are kits and compositions comprising the same for use in predicting and/or diagnosing CV events.

Inventors:
EKROOS KIM (FI)
SYSI-AHO MARKO (FI)
HILVO MIKA (FI)
HURME REINI (FI)
LAAKSONEN REIJO (FI)
VÄISÄNEN VIRVE (FI)
Application Number:
PCT/EP2016/080124
Publication Date:
November 23, 2017
Filing Date:
December 07, 2016
Export Citation:
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Assignee:
ZORA BIOSCIENCES OY (FI)
International Classes:
G01N33/92
Domestic Patent References:
WO2007140433A22007-12-06
WO2014144561A22014-09-18
WO2013184628A12013-12-12
WO2000023612A12000-04-27
WO2012012693A22012-01-26
Foreign References:
US20150247873A12015-09-03
US20130023054A12013-01-24
US20130045217A12013-02-21
US20130216560A12013-08-22
US20150160247A12015-06-11
US20120004854A12012-01-05
Other References:
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Attorney, Agent or Firm:
DÖRRIES, H. Ulrich (DE)
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