Title:
USE OF CHITOSAN MODIFIED BY FLUORINE-CONTAINING COMPOUND AS DRUG CARRIER AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2021/147585
Kind Code:
A1
Abstract:
A chitosan derivative that is modified by fluorination and that is used as a drug carrier, having the following structure: a fluorine-containing compound is covalently linked to a chitosan backbone, said chitosan has a molecular weight within a range of 5000-5000000, the fluorine-containing compound is a fluorine-containing aliphatic chain represented by chemical formula (I) below or is an aromatic ring functional group represented by formula (II), R1 is halogen (fluorine, chlorine, bromine, iodine), halogen-substituted alkane, cycloalkane, an aldehyde group, a carboxyl group, a double bond, an alkyne bond, a hydroxyl group, sulfuryl chloride, a sulfonic acid bond, or a mercapto group, and said active groups can react with a primary amino group. Further provided is a novel drug carrier material having a significant effect of promoting drug absorption and having low toxicity. The described chitosan modified by a fluorine-containing compound features a mature synthesis process, simple operation, high synthesis efficiency and a short cycle. High-yield drug carriers can be obtained without tedious purification steps. The simple synthesis method therefor provides a good basis for the commercialization of said chitosan.
Inventors:
LIU ZHUANG (CN)
ZHAO QI (CN)
JIN QIUTONG (CN)
ZHU WENJUN (CN)
ZHAO QI (CN)
JIN QIUTONG (CN)
ZHU WENJUN (CN)
Application Number:
PCT/CN2020/137711
Publication Date:
July 29, 2021
Filing Date:
December 18, 2020
Export Citation:
Assignee:
UNIV SOOCHOW (CN)
International Classes:
C08B37/08; A61K31/704; A61K47/36; A61P35/00
Foreign References:
| CN111848830A | 2020-10-30 | |||
| CN110585130A | 2019-12-20 | |||
| CN104854134A | 2015-08-19 | |||
| CN103316362A | 2013-09-25 | |||
| CN107522880A | 2017-12-29 | |||
| CN108904804A | 2018-11-30 | |||
| CN101550200A | 2009-10-07 |
Other References:
LI GUANGZHI, LEI QIFANG, WANG FEI, DENG DASHI, WANG SHUPENG, TIAN LONGLONG, SHEN WANWAN, CHENG YIYUN, LIU ZHUANG, WU SONG: "Fluorinated Polymer Mediated Transmucosal Peptide Delivery for Intravesical Instillation Therapy of Bladder Cancer", SMALL, WILEY, vol. 15, no. 25, 1 June 2019 (2019-06-01), pages 1900936, XP055830952, ISSN: 1613-6810, DOI: 10.1002/smll.201900936
Attorney, Agent or Firm:
CENTRAL SOUTH WELL INTELLECTUAL PROPERTY OFFICE (CN)
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