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Title:
USE OF CYTOSKELETON MODIFYING COMPOUNDS AGAINST INTRACRANIAL PRESSURE CHANGES
Document Type and Number:
WIPO Patent Application WO2001064219
Kind Code:
A3
Abstract:
Cytoskeleton modifying compounds modulate water homeostasis in cells expressing aquaporin 4 water channels and thus offer the possibility of intervening in water shifts, edema formation and intracranial pressure rise during and after head trauma or ischemic episodes.

Inventors:
VAN DEN KIEBOOM GERD MARIA (BE)
NUYDENS RONY MARIA (BE)
GEERTS HUGO ALFONS GABRIEL (BE)
Application Number:
PCT/EP2001/001885
Publication Date:
July 18, 2002
Filing Date:
February 20, 2001
Export Citation:
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Assignee:
JANSSEN PHARMACEUTICA NV (BE)
VAN DEN KIEBOOM GERD MARIA (BE)
NUYDENS RONY MARIA (BE)
GEERTS HUGO ALFONS GABRIEL (BE)
International Classes:
A61K31/475; A61P7/10; (IPC1-7): A61K31/475; A61K31/415; A61K31/42; A61K31/565; A61K31/40; A61K31/165; A61P7/10
Foreign References:
Other References:
CRISCUOLO, G.R. ET AL: "Clinical neurosciences in the decade of the brain: Hypotheses in neuro-oncology. VEG/PF acts upon the actin cytoskeleton and is inhibited by dexamethasone: Relevance to tumor angiogenesis and vasogenic edema", YALE JOURNAL OF BIOLOGY AND MEDICINE, vol. 69, no. 4, 1996, pages 337 - 355, XP000912053
HOLMIN, S. ET AL: "Dexamethasone and colchicine reduce inflammation and delayed oedema following experimental brain contusion", ACTA NEUROCHIRURGICA, vol. 138, no. 4, 1996, pages 418 - 424, XP000911998
VIGNES, S. ET AL: "Présentation pseudotumorale de neuro-Behçet: rôle de l'arrêt de la colchicine?", LA REVUE DE MÉDECINE INTERNE, vol. 19, no. 1, 1998, pages 55 - 59, XP000911851
SABOLIC, I. ET AL: "The AQP2 water channel: Effect of vasopressin treatment, microtubule disruption and distribution in neonatal rats", JOURNAL OF MEMBRANE BIOLOGY, vol. 143, no. 3, 1995, pages 165 - 175, XP000911853
BORGES, N. ET AL: "Dynamics of experimental vasogenic brain oedema in the rat: changes induced by adrenergic drugs", JOURNAL OF AUTONOMIC PHARMACOLOGY, vol. 19, no. 4, 1999, pages 209 - 217, XP000911852
ELKJAER, M.-L. ET AL: "Effects of microtubule disruption on endocytosis, membrane recycling and polarized distribution of aquaporin-1 and gp330 in proximal tubuke cells", EUROPEAN JOURNAL OF CELL BIOLOGY, vol. 67, no. 1, 1995, pages 57 - 72, XP000911897
UMENISHI, F. ET AL: "cAMP regulated membrane diffusion of a green fluorescent protein-aquaporin 2 chimera", BIOPHYSICAL JOURNAL, vol. 78, no. 2, February 2000 (2000-02-01), pages 1024 - 1035, XP000911933
DIBAS, A. ET AL: "Microfilament network is needed for the endocytosis of water channels and not for apical membrane insertion upon vasopressin action", PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE, vol. 223, no. 2, February 2000 (2000-02-01), pages 203 - 209, XP000911985
ISHIKAWA, Y. ET AL: "alpha1-Adrenoceptor-induced trafficking of aquaporin-5 to the apical plasma membrane of rat parotid cells", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 265, no. 1, November 1999 (1999-11-01), pages 94 - 100, XP002146411
BROWN, D. ET AL: "Association of AQP2 with actin in transfected LLC-PK1 cells and rat papilla", JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, vol. 7, no. 9, 1996, pages 1265, XP000911880
TADA, J. ET AL: "Involvement of vesicle-cytoskeleton interaction in AQP5 trafficking in AQP5-gene-transfected HSG cells", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 266, 1999, pages 443 - 447, XP000938689
DATABASE CHEMABS CHEMICAL ABSTRACTS SERVICE, COLUMBUS, OHIO, US; XP002147115
MARGULIES, J.E. ET AL: "Differential display of gene expression in a surgical model of cerebral edema", SOCIETY FOR NEUROSCIENCE ABSTRACTS, vol. 25, no. 1-2, 1999, pages 825, XP000912188
MANLEY, G.T. ET AL: "Aquaporin-4 deletion in mice reduces brain edema after acute water intoxication and ischemic stroke", NATURE MEDICINE, vol. 6, no. 2, February 2000 (2000-02-01), pages 159 - 163, XP000938619
VIZUETE, M.L. ET AL: "Differential upregulation of aquaporin-4 mRNA expression in reactive astrocytes after brain injury: potential role in brain edema", NEUROBIOLOGY OF DISEASE, vol. 6, 1999, pages 245 - 258, XP000911889
HAN, Z. ET AL: "Regulation of aquaporin-4 water channels by phorbol ester-dependent protein phosphorylation", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 273, no. 11, 1998, pages 6001 - 6004, XP002147114
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