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Title:
USE OF FLAGELLIN AS AN ADJUVANT FOR VACCINE
Document Type and Number:
WIPO Patent Application WO2005107381
Kind Code:
A3
Abstract:
The present invention is directed to flagellin and its use as an adjuvant for vaccination. Preferably, flagellin is membrane bound, which might be achieved by using the mammalian surface display plasmid pDisplay. The invention can be used in vaccine formulations to improve immunity against any other antigen administered at the same localization. The antigen can be administered in the same construct as flagellin or in any other formulation given at the same localization. As an alternative flagellin can be used to stimulate immunity against antigens expressed at a specific location. Flagellin can also be used to induce local inflammation with the purpose of creating a model for inflammation.

Inventors:
LJUNGGREN HANS-GUSTAF (SE)
APPELQUIST STEVE (SE)
HINKULA JORMA (SE)
ROSELL BJOERN (SE)
ROLLMAN ERIK (SE)
Application Number:
PCT/SE2005/000636
Publication Date:
December 29, 2005
Filing Date:
May 02, 2005
Export Citation:
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Assignee:
LJUNGGREN HANS-GUSTAF (SE)
APPELQUIST STEVE (SE)
HINKULA JORMA (SE)
ROSELL BJOERN (SE)
ROLLMAN ERIK (SE)
International Classes:
A61K39/39; (IPC1-7): A61K39/39
Domestic Patent References:
WO2002085933A12002-10-31
WO1989006971A11989-08-10
WO1989010967A11989-11-16
WO2004022092A22004-03-18
WO2005025614A22005-03-24
Foreign References:
US5837825A1998-11-17
Other References:
PEREIRA C.M. ET AL: "Antibody response against Escherichia coli heat-stable enterotoxin expressed as fusions to flagellin", MICROBIOLOGY, vol. 147, 2001, pages 861 - 867, XP008074337
WANG M. ET AL: "Construction of DNA Vaccin Including a Chimeric Gene Encoding Falgellin and Outer Membrane Protein Antigen from Leptospira Interrogons Serovar Lai", JOURNAL OF WEST CHINA UNIVERSITY OF MEDICAL SCIENCES, vol. 33, no. 2, 2002, pages 169 - 171, XP008074372
CHEN I. ET AL: "Effects of the insertion of a nonapeptide from murine IL-1Beta on the immunogenicity of carrier proteins delivered by live attenuated Salmonella", ARCH MICROBIOL, vol. 169, 1998, pages 113 - 119, XP008074373
EAVES-PYLES T. ET AL: "Flagellin, a Novel Mediator of Salmonella-Induced Epithelial Activation and Systemic Inflammation: IkappaBalpha Degradation, Induction of Nitric Oxide Synthase, Induction of Proinflammatory Mediators, and Cardiovascular Dysfunction1", THE JOURNAL OF IMMUNOLOGY, vol. 166, no. 2, 15 January 2001 (2001-01-15), pages 1248 - 1260, XP002210841
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