Title:
USE OF FREDERICAMYCIN A AND ITS DERIVATIVES IN THE TREATMENT OF PIN1-ASSOCIATED STATES
Document Type and Number:
WIPO Patent Application WO2002060436
Kind Code:
A3
Abstract:
This invention provides a method for treating a Pin1-associated state in a subject including administering to a subject an effective amount of a fredericamycin A compound such that the Pin1-associated state is treated. In another aspect, this invention includes the above described method, wherein the Pin1-associated state is a cyclin D1 elevated state, neoplastic transformation, and/or tumor growth. In an embodiment, this invention provides the above described methods, wherein the Pin1-associated state is colon cancer, breast cancer, a sarcoma, a malignant lymphoma, and/or esophageal cancer. This invention also provides a method for treating cyclin D1 overexpression in a subject including administering to a subject an effective amount of a combination of a fredericamycin A compound and a hyperplastic inhibitory agent such that the cyclin D1 overexpression is treated.
Inventors:
PING LU KUN (US)
FISCHER GUNTER (DE)
FISCHER GUNTER (DE)
Application Number:
PCT/US2001/050597
Publication Date:
January 23, 2003
Filing Date:
December 21, 2001
Export Citation:
Assignee:
PINTEX PHARMACEUTICALS (US)
PING LU KUN (US)
FISCHER GUNTER (DE)
PING LU KUN (US)
FISCHER GUNTER (DE)
International Classes:
A61K31/138; A61K31/203; A61K31/337; A61K31/366; C07D221/20; A61K31/37; A61K31/382; A61K31/473; A61K31/4747; A61K31/519; A61K31/7048; A61K38/00; A61P35/00; A61P35/02; A61P43/00; C07D493/20; C07H17/04; (IPC1-7): A61K31/37; A61K31/382; A61K31/473; A61P35/00
Foreign References:
| US4584377A | 1986-04-22 | |||
| US3914257A | 1975-10-21 |
Other References:
CLIVE D L J ET AL: "Further Model Studies Related to Fredericamycin A: Analogues in which Ring C is Expanded to Six Atoms, and an Examination of the Diastereoselectivity of Radical Spirocyclization", TETRAHEDRON, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 52, no. 17, 22 April 1996 (1996-04-22), pages 6085 - 6116, XP004104173, ISSN: 0040-4020
THRASH T P ET AL: "Synthesis of an elaborated heliquinomycin isocoumarin moiety", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 41, no. 1, January 2000 (2000-01-01), pages 29 - 31, XP004185409, ISSN: 0040-4039
"The Merk Manual of Diagnosis and Therapy", 1999, MERCK RESEARCH LABORATORIES, XP002205734
STROSHANE R M ET AL: "Isolation and structure elucidation of a novel griseorhodin", THE JOURNAL OF ANTIBIOTICS, vol. 32, no. 3, March 1979 (1979-03-01), pages 197 - 204, XP001084309
CAPECCHI T ET AL: "Nitroalkenes as Precursors to the Aromatic Spiroketal Skeleton of gamma-Rubromycin. A Nef-type Reaction Mediated by Pearlman's Catalyst", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 39, no. 30, 23 July 1998 (1998-07-23), pages 5429 - 5432, XP004123251, ISSN: 0040-4039
THRASH T P ET AL: "Synthesis of an elaborated heliquinomycin isocoumarin moiety", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 41, no. 1, January 2000 (2000-01-01), pages 29 - 31, XP004185409, ISSN: 0040-4039
"The Merk Manual of Diagnosis and Therapy", 1999, MERCK RESEARCH LABORATORIES, XP002205734
STROSHANE R M ET AL: "Isolation and structure elucidation of a novel griseorhodin", THE JOURNAL OF ANTIBIOTICS, vol. 32, no. 3, March 1979 (1979-03-01), pages 197 - 204, XP001084309
CAPECCHI T ET AL: "Nitroalkenes as Precursors to the Aromatic Spiroketal Skeleton of gamma-Rubromycin. A Nef-type Reaction Mediated by Pearlman's Catalyst", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 39, no. 30, 23 July 1998 (1998-07-23), pages 5429 - 5432, XP004123251, ISSN: 0040-4039
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