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Title:
USE OF FUSION PROTEINS E-CADHERIN-FC, VE-CADHERIN-FC AND VEGF-FC
Document Type and Number:
WIPO Patent Application WO/2019/242781
Kind Code:
A1
Abstract:
An application of an epithelial cadherin-Fc fusion protein (E-cad-Fc), a vascular endothelial cadherin-Fc fusion protein (VE-cad-Fc) and a VEGF-Fc in inducing cells to differentiate into hepatocyte-like cells, endothelial-like cells, biliary epithelial-like cells and islet-like cells.

Inventors:
YANG JUN (CN)
CAO LEI (CN)
ZHANG YAN (CN)
WANG XUEPING (CN)
CHEN GUOQIANG (CN)
Application Number:
PCT/CN2019/096004
Publication Date:
December 26, 2019
Filing Date:
July 15, 2019
Export Citation:
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Assignee:
UNIV NANKAI (CN)
International Classes:
C12N5/071; C07K19/00
Foreign References:
CN109337857A2019-02-15
CN104804098A2015-07-29
CN104651300A2015-05-27
JP6139054B22017-05-31
Other References:
XU, KE ET AL.: "Human VE -Cadherin Fusion Protein as an Artificial Extracellular Matrix Enhancing theProliferation and Differentiation Functions of Endothelial Cell", BIOMACROMOLECULES, vol. 17, 9 February 2016 (2016-02-09), pages 756 - 766
XU, JIANBIN ET AL.: "Human E-Cadherin-Fc Fusion Protein Matrix Improving the Hepatic Differentiation of Human Mesenchymal Stem Cells", CHINESE JOURNAL OF BIOMEDICAL ENGINEERING, vol. 32, no. 6, 31 December 2013 (2013-12-31), pages 708 - 714
ZHANG, YAN ET AL.: "Surface modification with E-cadherin fusion protein for mesenchymal stem cell culture", JOURNAL OF MATERIALS CHEMISTRY B, vol. 4, no. 24, 31 December 2016 (2016-12-31), pages 4267 - 4277, XP055667713, ISSN: 2050-750X
YU , MEIHUA ET AL.: "Preparation and characterization of a VEGF-Fc fusion protein matrix for enhancing HUVEC growth", BIOTECHNOL LETT, vol. 34, 31 December 2012 (2012-12-31), pages 1765 - 1771, XP035105225, DOI: 10.1007/s10529-012-0959-7
Attorney, Agent or Firm:
CHINA SCIENCE PATENT & TRADEMARK AGENT LTD. (CN)
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