Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
USE OF NICOTINAMIDE MONONUCLEOTIDE IN PREPARATION OF ANTI-RADIATION INJURY PREPARATION
Document Type and Number:
WIPO Patent Application WO/2022/150948
Kind Code:
A1
Abstract:
The present invention relates to the technical field of medicines, in particular, provided is the use of a nicotinamide mononucleotide (NMN) in an anti-radiation injury preparation. In vitro cell experiments show that the NMN can significantly promote the proliferation ability of normal cells and senescent cells, and improve the survival rate of irradiated cells, reduce the formation of DNA damage protein γH2AX foci after irradiation, shorten the comet tail distance, significantly improve DNA damage conditions, and enhance the ability of same to perform DNA damage repair. In addition, an NMN-treated PARP protein and NAD +-dependent deacetylase SIRT family are significantly increased, and the levels of DNA damage repair protein SIRT1, telomere-related SIRT6 and transcription-related SIRT7 protein are significantly increased, which provides a new basis for NMN to prevent and treat the damage caused by ionizing radiation.

Inventors:
LIU YANG (CN)
YU JIANJUN (CN)
XU QINYUAN (CN)
HUANG HAO (CN)
Application Number:
PCT/CN2021/071192
Publication Date:
July 21, 2022
Filing Date:
January 12, 2021
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
INST OF RADIATION MEDICINE CHINESE ACADEMY OF MEDICAL SCIENCES AND PEKING UNION MEDICAL COLLEGE (CN)
EFFEPHARM SHANGHAI CO LTD (CN)
International Classes:
A61K31/706; A23L33/13; A61K8/60; A61P17/16; A61P39/00; A61Q19/00
Foreign References:
CN104814974A2015-08-05
CN111166760A2020-05-19
CN110461339A2019-11-15
CN111789822A2020-10-20
CN111557910A2020-08-21
CN110974781A2020-04-10
CN109364091A2019-02-22
CN111658621A2020-09-15
CN110812365A2020-02-21
Other References:
BAVARIAN ROXANNE: "The Role of Nicotinamide Adenine Dinucleotide in the Treatment of Oral Mucositis", . DOCTORAL DISSERTATION, HARVARD SCHOOL OF DENTAL MEDICINE., 30 November 2019 (2019-11-30), XP055950967, Retrieved from the Internet
LI JUN ET AL.,: "A conserved NAD+ binding pocket that regulates protein-protein interactions during aging,", SCIENCE., vol. 355, no. 6331, 24 March 2017 (2017-03-24), XP055474350, DOI: 10.1126/science.aad8242
ZHAO, CHUAN ET AL.: "5 Reducing Harmful Mutation and Damage of DNA", MODERN HEALTH MEDICINE, 31 May 2019 (2019-05-31), CN, pages 194 - 195, XP009538632, ISBN: 978-7-5331-9816-9
Attorney, Agent or Firm:
SHANGHAI SUNHOLD LAW FIRM (CN)
Download PDF: