Title:
USE OF PROCYANIDINS IN THE MAINTENANCE OF VASCULAR HEALTH AND MODULATION OF THE INFLAMMATORY RESPONSE
Document Type and Number:
WIPO Patent Application WO2001041775
Kind Code:
A3
Abstract:
Methylated procyanidins which include procyanidin monomers and their oligomers are useful in the modulation of inflammatory pathways, in the maintenance of the vascular health of a mammal and as an antibacterial treatment. They can be included in foods, food supplements and pharmaceuticals for the inhibition of COX activity, the inhibition of LOX activity, the enhancement of nitric oxide production, the modulation of eicosanoids and endothelin, and the modulation of platelet activity.
Inventors:
ROMANCZYK LEO J JR (US)
SCHMITZ HAROLD H (US)
SCHMITZ HAROLD H (US)
Application Number:
PCT/US2000/033531
Publication Date:
January 17, 2002
Filing Date:
December 10, 2000
Export Citation:
Assignee:
MARS INC (US)
ROMANCZYK LEO J JR (US)
SCHMITZ HAROLD H (US)
ROMANCZYK LEO J JR (US)
SCHMITZ HAROLD H (US)
International Classes:
A61K9/20; A61K31/353; A61K35/00; A61K36/00; A61K36/185; A61P9/00; C07D311/62; C07H17/06; (IPC1-7): A61K35/78; A61P9/00
Domestic Patent References:
| WO1999045797A1 | 1999-09-16 |
Other References:
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1990, ROHRBACH M S ET AL: "STRUCTURAL DETERMINANTS OF THE PLATELET AGONIST ACTIVITY OF COTTON BRACT CONDENSED TANNIN", XP002166001, Database accession no. PREV199090117512
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