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Title:
USE OF QUERCETIN-O-GLYCOSIDE DERIVATIVES IN TREATING LIPID METABOLISM DISORDERS
Document Type and Number:
WIPO Patent Application WO/2015/169121
Kind Code:
A1
Abstract:
The present invention relates to the field of pharmaceutical synthesis and pharmacology, in particular to a method for preparing a class of quercetin-O-glycoside derivatives and the use thereof in treating lipid metabolism disorders. The derivatives, such as the compounds of formula I, comprise salts of the compounds of formula I and optical isomers and racemates of the compounds of formula (I). The technical problem to be solved by the present invention is to design and synthesize a class of quercetin-O-glycoside derivatives, and in vitro and in vivo pharmacological activity studies found that the quercetin-O-glycoside derivatives can play a lipid-lowering role in both in vivo and in vitro experiments. In addition, the present invention also provides a pharmaceutical composition for treating lipid metabolism disorders.

Inventors:
SHANG JING (CN)
LI YU (CN)
JIN YU (CN)
LV JINPENG (CN)
WANG LULU (CN)
ZHANG ZHICHAO (CN)
Application Number:
PCT/CN2015/073814
Publication Date:
November 12, 2015
Filing Date:
March 06, 2015
Export Citation:
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Assignee:
NANJING RUIYING RUNZE BIOPHARMACEUTICAL TECHNOLOGY CO INC (CN)
International Classes:
C07H17/07; A61K31/7048; A61P1/16; A61P3/06; A61P9/10; C07H1/00
Domestic Patent References:
WO2008032105A22008-03-20
Foreign References:
CN101683353A2010-03-31
CN1978452A2007-06-13
CN1880328A2006-12-20
CN1817876A2006-08-16
CN1470518A2004-01-28
Attorney, Agent or Firm:
NANJING JINGWEI PATENT & TRADEMARK AGENCY CO., LTD (No. 179 Zhongshan Road Gulo, Nanjing Jiangsu 5, CN)
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