USE OF SILICON COMPOUND IN CYCLIZATION REACTION - LANZHOU CHEMSPECWEIER CHEMICAL CO LTD

Title:

USE OF SILICON COMPOUND IN CYCLIZATION REACTION

Document Type and Number:

WIPO Patent Application WO/2022/166764

Kind Code:

A1

Abstract:

The present invention relates to the field of organic chemistry, and in particular, relates to a use of a silicon compound in a cyclization reaction. On one hand, the present invention provides a method for preparing 2-chloro-5-chloromethylpyridine, comprising: performing a cyclization reaction on 4-aldehydo-4,5-dichlorovaleronitrile in the presence of a silicon compound and an amide compound, so as to provide the 2-chloro-5-chloromethylpyridine. On the other hand, the present invention provides a method for preparing 5-chloromethyl-2-trifluoromethyl-1,3,4-oxadiazole, comprising: performing a cyclization reaction on 1-(chloroacetyl)-2-(trifluoroacetyl)hydrazine in the presence of a silicon compound and an amide compound, so as to provide the 5-chloromethyl-2-trifluoromethyl-1,3,4-oxadiazole. By using the silicon compound or/and amide provided by the present invention as a cyclization reagent, cyclization synthesis can be efficiently performed.

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Inventors:

HE LI (CN)
LI XIAOLIANG (CN)
LIU ZHENLI (CN)
TIAN ZHONG (CN)
DUAN HANQING (CN)

Application Number:

PCT/CN2022/074346

Publication Date:

August 11, 2022

Filing Date:

January 27, 2022

Export Citation:

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Assignee:

LANZHOU CHEMSPECWEIER CHEMICAL CO LTD (CN)
SHANGHAI CHEMSPEC CORP (CN)

International Classes:

C07D271/10; C07D213/61

Domestic Patent References:

WO2012106569A1	2012-08-09
WO2012048502A1	2012-04-19

Foreign References:

US20130338196A1	2013-12-19
US4469896A	1984-09-04
US4245098A	1981-01-13
US4665186A	1987-05-12
CN103396357A	2013-11-20
US5229519A	1993-07-20

Other References:

BENOIT RIGO , DOMINIQUE FASSEUR , PASCAL CAULIEZ , DANIEL COUTURIER: "Disilyltaed Compounds As Precursors Of Heterocycles: A New and Easy Oxadiazole Synthesis", SYNTHETIC COMMUNICATIONS, vol. 19, no. 13-14, 31 December 1989 (1989-12-31), US , pages 2321 - 2335, XP009538808, ISSN: 0039-7911, DOI: 10.1080/00397918908052631
FINE AND SPECIALTY CHEMICALS, vol. 18, no. 1, 2010, pages 47 - 49

Attorney, Agent or Firm:

J.Z.M.C. PATENT AND TRADEMARK LAW OFFICE (CN)

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