Title:
USE FOR ULVA POLYSACCHARIDE IN SUPPRESSING β-AMYLOID PROTEIN AGGREGATION
Document Type and Number:
WIPO Patent Application WO/2021/027977
Kind Code:
A1
Abstract:
A use for an Ulva polysaccharide in suppressing β-amyloid protein aggregation, relating to the technical fields of medicine, health products, or food products. When the Ulva polysaccharide is used in preparing a drug, a health product, or a food product, the Ulva polysaccharide is able to effectively suppress β-amyloid protein aggregation, thereby preventing the occurrence of Alzheimer's disease. Within a certain range of concentrations, the suppression result improves along with increased Ulva polysaccharide concentration. The Ulva polysaccharide changes the morphology of aggresomes, preventing and slowing down the transformation thereof into a fibrous morphology. Meanwhile, cytotoxicity caused by aggresomes formed in a process of β-amyloid protein aggregation is effectively suppressed.
Inventors:
LIU FUFENG (CN)
ZHAO WENPING (CN)
LU FUPING (CN)
ZHAO WENPING (CN)
LU FUPING (CN)
Application Number:
PCT/CN2020/119980
Publication Date:
February 18, 2021
Filing Date:
October 09, 2020
Export Citation:
Assignee:
TIANJIN UNIV OF SCIENCE AND TECHNOLOGY (CN)
International Classes:
A61K31/715; A23L33/125; A61K36/05; A61P25/28
Domestic Patent References:
| WO2010096925A1 | 2010-09-02 | |||
| WO2014074592A1 | 2014-05-15 |
Foreign References:
| CN105050608A | 2015-11-11 | |||
| CN110420216A | 2019-11-08 |
Other References:
OLASEHINDE TOSIN A. ET AL.: "Chemical Characterization, Antioxidant Properties, Cholinesterase Inhibitory and Anti-Amyloidogenic Activities of Sulfated Polysaccharides from Some Seaweeds,", BIOACTIVE CARBOHYDRATES AND DIETARY FIBRE,, vol. 18, 30 April 2019 (2019-04-30), pages 100182, XP055781659
OLASEHINDE TOSIN A. ET AL,: "Chemical Characterization of Sulfated Polysaccharides from Gracilaria Gracilis and Ulva Lactuca and Their Radical Scavenging, Metal Chelating, and Cholinesterase Inhibitory Activities,", INTERNATIONAL JOURNAL OF FOOD PROPERTIES,, vol. 22, no. 1, 14 February 2019 (2019-02-14), pages 100 - 110, XP055781669
LIU, FUFENG ET AL.: "Dual Effect of the Acidic Polysaccharose Ulvan on the Inhibition of Amyloid-β Protein Fibrillation and Disintegration of Mature Fibrils,", ACS APPLIED MATERIALS & INTERFACES, vol. 12, no. 37, 20 August 2020 (2020-08-20), pages 41167 - 41176, XP055781673
OLASEHINDE TOSIN A. ET AL.: "Macroalgae as a Valuable Source of Naturally Occurring Bioactive Compounds for the Treatment of Alzheimer's Disease,", MARINE DRUGS,, vol. 17, no. 609, 25 October 2019 (2019-10-25), pages 1 - 18, XP055781678
QI HUIMIN ET AL,: "Antioxidant Activity of High Sulfate Content Derivative of Ulvan in Hyperlipidemic Rats,", INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,, vol. 76, 13 March 2015 (2015-03-13), pages 326 - 329, XP055781680
OLASEHINDE TOSIN A. ET AL,: "Chemical Characterization of Sulfated Polysaccharides from Gracilaria Gracilis and Ulva Lactuca and Their Radical Scavenging, Metal Chelating, and Cholinesterase Inhibitory Activities,", INTERNATIONAL JOURNAL OF FOOD PROPERTIES,, vol. 22, no. 1, 14 February 2019 (2019-02-14), pages 100 - 110, XP055781669
LIU, FUFENG ET AL.: "Dual Effect of the Acidic Polysaccharose Ulvan on the Inhibition of Amyloid-β Protein Fibrillation and Disintegration of Mature Fibrils,", ACS APPLIED MATERIALS & INTERFACES, vol. 12, no. 37, 20 August 2020 (2020-08-20), pages 41167 - 41176, XP055781673
OLASEHINDE TOSIN A. ET AL.: "Macroalgae as a Valuable Source of Naturally Occurring Bioactive Compounds for the Treatment of Alzheimer's Disease,", MARINE DRUGS,, vol. 17, no. 609, 25 October 2019 (2019-10-25), pages 1 - 18, XP055781678
QI HUIMIN ET AL,: "Antioxidant Activity of High Sulfate Content Derivative of Ulvan in Hyperlipidemic Rats,", INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,, vol. 76, 13 March 2015 (2015-03-13), pages 326 - 329, XP055781680
Attorney, Agent or Firm:
BEIJING RISINGMARK INTELLECTUAL PROPERTY AGENCY (CN)
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