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Title:
USE OF VALERIC ACID DERIVATIVE IN TREATMENT OF DOWN'S SYNDROME
Document Type and Number:
WIPO Patent Application WO/2021/063414
Kind Code:
A1
Abstract:
Use of a compound as shown in formula I in preparation of a medicament for prevention, treatment or amelioration of learning, memory and cognitive impairment of Down's syndrome. The compound as shown in formula I can enhance the learning and memory ability of a Down's mouse, increase the number of synapses in the hippocampus of the Down's mouse, and can restore the damaged phagocytic function of the brain microglia cell of the Down's mouse. Therefore, the compound can be used as a therapeutic medicament to be applied to the symptoms of learning, memory and cognitive impairment of Down's syndrome.

Inventors:
WANG XIN (CN)
ZHANG SHUO (CN)
ZHENG QIUYANG (CN)
LIN ZHIHAO (CN)
WANG SHIHUA (CN)
ZHOU YUANYUAN (CN)
Application Number:
PCT/CN2020/119690
Publication Date:
April 08, 2021
Filing Date:
September 30, 2020
Export Citation:
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Assignee:
UNIV XIAMEN (CN)
International Classes:
A61K31/19; A61K31/215; A61P25/00
Foreign References:
CN1886363A2006-12-27
CN103476255A2013-12-25
CN102227217A2011-10-26
Other References:
SINISCALCHI ANTONIO, GALLELLI LUCA, LOIZZO SIMONA, TIZIANA AVENOSO, RUSSO EMILIO, DE SARRO GIOVAMBATTISTA: "Sodium Valproate Induced Tremor in a Patient with Epilepsy and Down's Syndrome", CURRENT DRUG SAFETY, vol. 8, 1 January 2013 (2013-01-01), pages 69 - 71, XP055797343
HAMOUDA HECHMI BEN, HANEN MNASRI, SOBHI GHANMI, HABIB SOUA, GAZI SAKLI, MOHAMED DOGUI, MOHAMED TAHAR SFAR: "West syndrome associated with Down syndrome:Case report and literature review", PEDIATRIA POLSKA, vol. 89, pages 203 - 206, XP055797346, DOI: 10.1016/j.pepo.2014.03.006
D’ORSI GIUSEPPE, SPECCHIO LUIGI M.: "Progressive myoclonus epilepsy in Down syndrome patients with dementia", JOURNAL OF NEUROLOGY - ZEITSCHRIFT FUER NEUROLOGIE, SPRINGER VERLAG, BERLIN., DE, vol. 261, no. 8, 1 August 2014 (2014-08-01), DE, pages 1584 - 1597, XP055797347, ISSN: 0340-5354, DOI: 10.1007/s00415-014-7376-x
KANE ROBERT E., SURESH KOTAGEL, BRUCE R. BACON, CAROLE A. VOGLER: "Valproate Use Associated with Persistent Hyperammonemia and Mitochondria Injury in a Child with Down's Syndrome", JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, vol. 14, no. 2, 1 January 1992 (1992-01-01), pages 223 - 227, XP055797351
SINISCALCHI ANTONIO, GALLELLI LUCA, LOIZZO SIMONA, TIZIANA AVENOSO, RUSSO EMILIO, DE SARRO GIOVAMBATTISTA: "Sodium Valproate Induced Tremor in a Patient with Epilepsy and Down's Syndrome", CURRENT DRUG SAFETY, vol. 8, 1 January 2013 (2013-01-01), pages 69 - 71, XP055797343
HAMOUDA HECHMI BEN, HANEN MNASRI, SOBHI GHANMI, HABIB SOUA, GAZI SAKLI, MOHAMED DOGUI, MOHAMED TAHAR SFAR: "West syndrome associated with Down syndrome:Case report and literature review", PEDIATRIA POLSKA, vol. 89, pages 203 - 206, XP055797346, DOI: 10.1016/j.pepo.2014.03.006
D’ORSI GIUSEPPE, SPECCHIO LUIGI M.: "Progressive myoclonus epilepsy in Down syndrome patients with dementia", JOURNAL OF NEUROLOGY - ZEITSCHRIFT FUER NEUROLOGIE, SPRINGER VERLAG, BERLIN., DE, vol. 261, no. 8, 1 August 2014 (2014-08-01), DE, pages 1584 - 1597, XP055797347, ISSN: 0340-5354, DOI: 10.1007/s00415-014-7376-x
KANE ROBERT E., SURESH KOTAGEL, BRUCE R. BACON, CAROLE A. VOGLER: "Valproate Use Associated with Persistent Hyperammonemia and Mitochondria Injury in a Child with Down's Syndrome", JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, vol. 14, no. 2, 1 January 1992 (1992-01-01), pages 223 - 227, XP055797351
"Genetics and Etiology of Down Syndrome", 29 August 2011, INTECH, ISBN: 978-953-30-7631-7, article NASCIMENTO A., ORTEZ-GONZALEZ C.: "Down Syndrome and Epilepsy", XP055797353, DOI: 10.5772/18314
Attorney, Agent or Firm:
XU & PARTNERS, LLC. (CN)
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