Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
USE OF ZBTB16 IN DEGENERATIVE BRAIN DISEASE
Document Type and Number:
WIPO Patent Application WO/2022/163959
Kind Code:
A1
Abstract:
In the present invention, it was found that degenerative brain disease can be diagnosed through zinc finger and BTB domain-containing protein 16 (ZBTB16) and the inhibition of expression of ZBTB16 leads to the amelioration, prevention, or treatment of the mental and behavioral symptoms of degenerative brain disease. Thus, the material can be utilized as a biomarker for degenerative brain disease as well as for prevention or treatment of degenerative brain disease.

Inventors:
IM HEH-IN (KR)
LEE SANGJOON (KR)
CHOI JI EUN (KR)
Application Number:
PCT/KR2021/010056
Publication Date:
August 04, 2022
Filing Date:
August 02, 2021
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
KOREA INST SCI & TECH (KR)
International Classes:
G01N33/68; A61K31/7105; A61K48/00; A61P25/28; C12N15/113; C12Q1/6883
Foreign References:
KR20120082906A2012-07-24
US7202025B12007-04-10
Other References:
ZOU CUIHUA, JIE WANG, XIAOHUA HUANG, CHONGDONG JIAN, DONGHUA ZOU, XUEBIN LI: "Analysis of transcription factor-and ncRNA-mediated potential pathogenic gene modules in alzheimer’s disease", AGING, vol. 11, no. 16, 16 August 2019 (2019-08-16), pages 6109 - 6119, XP055953852, DOI: 10.18632/aging.102169
LIN DAR-SHONG, HO CHE-SHENG, HUANG YU-WEN, WU TSU-YEN, LEE TSUNG-HAN, HUANG ZO-DARR, WANG TUAN-JEN, YANG SHUN-JIE, CHIANG MING-FU: "Impairment of Proteasome and Autophagy Underlying the Pathogenesis of Leukodystrophy", CELLS, vol. 9, no. 5, pages 1124, XP055953844, DOI: 10.3390/cells9051124
KUNIKAZU TANJI;YASUO MIKI;TAKU OZAKI;ATSUSHI MARUYAMA;HIDEMI YOSHIDA;JUNSEI MIMURA;TOMOH MATSUMIYA;FUMIAKI MORI;TADAATSU IMAIZUMI;: "Phosphorylation of serine 349 of p62 in Alzheimer?s disease brain", ACTA NEUROPATHOLOGICA COMMUNICATIONS, BIOMED CENTRAL LTD, LONDON, UK, vol. 2, no. 1, 3 May 2014 (2014-05-03), London, UK , pages 50, XP021187127, ISSN: 2051-5960, DOI: 10.1186/2051-5960-2-50
Attorney, Agent or Firm:
CHUNG HYUN PATENT & LAW FIRM (KR)
Download PDF: