Title:
USEFUL MICROORGANISM, AND METHOD FOR PRODUCING DESIRED SUBSTANCE
Document Type and Number:
WIPO Patent Application WO/2014/007273
Kind Code:
A1
Abstract:
The present invention addresses the problem of providing a microbial strain which enables the reduction of the amount of a metabolite (M) converted from a compound (P) which is an intermediate metabolite and also enables the highly efficient accumulation of the compound (P) in a culture medium to which the metabolite (M) or an end product produced from the metabolite (M) is not added. The present invention provides a prokaryote having all of the properties mentioned in items (a) to (d) defined in the description, for the purpose of accumulating a compound (P), which is an intermediate metabolite, by controlling the expression amount of an enzyme (X) capable of converting the compound (P) into a metabolite (M), which is a compound essential for growth, in a biosynthesis pathway for producing the metabolite (M) from a carbon source.
Inventors:
IIDA KOUGO (JP)
IWASAKI TAKUMI (JP)
NISHI TATSUNARI (JP)
IWASAKI TAKUMI (JP)
NISHI TATSUNARI (JP)
Application Number:
PCT/JP2013/068205
Publication Date:
January 09, 2014
Filing Date:
July 03, 2013
Export Citation:
Assignee:
GENARIS INC (JP)
International Classes:
C12N1/21; C12P7/42; C12P7/46; C12P9/00; C12P13/00; C12P13/02; C12P13/06; C12P13/08; C12P13/14; C12P13/20; C12N15/09; C12R1/15; C12R1/19
Domestic Patent References:
| WO2011138006A1 | 2011-11-10 |
Foreign References:
| JP2010207094A | 2010-09-24 | |||
| JP2000295996A | 2000-10-24 | |||
| JP2006508684A | 2006-03-16 | |||
| US5272073A | 1993-12-21 | |||
| JPS6098989A | 1985-06-01 | |||
| JP2007300809A | 2007-11-22 | |||
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| JPS5089592A | 1975-07-18 | |||
| JPS6098989A | 1985-06-01 | |||
| JPS5867699A | 1983-04-22 | |||
| JPS5877895A | 1983-05-11 |
Other References:
LI, K. ET AL.: "Microbial synthesis of 3-dehydroshikimic acid: a comparative analysis of D-xylose, L-arabinose, and D- glucose carbon sources", BIOTECHNOL. PROG., vol. 15, no. 5, 1999, pages 876 - 883, XP055178510
TERAMOTO, H. ET AL.: "Regulation of expression of genes involved in quinate and shikimate utilization in Corynebacterium glutamicum", APPL. ENVIRON. MICROBIOL., vol. 75, no. 11, 2009, pages 3461 - 3468, XP009173982
MORAWSKI, B. ET AL.: "Repression of Acinetobacter vanillate demethylase synthesis by VanR, a member of the GntR family of transcriptional regulators", FEMS MICROBIOL. LETT., vol. 187, 2000, pages 65 - 68, XP055178512
STRATAGENE, STRATEGIES, vol. 5, 1992, pages 81
PROC. NATL. ACAD. SCI. U.S.A., vol. 69, 1972, pages 2110
NUCLEIC ACIDS RES., vol. 16, 1988, pages 6127
VAN DER REST ET AL., APPL. MICROBIOL. BIOTECHNOL., vol. 52, 1999, pages 541
PROC. NATL. ACAD. SCI. U.S.A., vol. 74, 1977, pages 5463
W. JAGER ET AL., J. BACTERIOL., vol. 174, 1992, pages 5462
TERAMOTO, H. ET AL.: "Regulation of expression of genes involved in quinate and shikimate utilization in Corynebacterium glutamicum", APPL. ENVIRON. MICROBIOL., vol. 75, no. 11, 2009, pages 3461 - 3468, XP009173982
MORAWSKI, B. ET AL.: "Repression of Acinetobacter vanillate demethylase synthesis by VanR, a member of the GntR family of transcriptional regulators", FEMS MICROBIOL. LETT., vol. 187, 2000, pages 65 - 68, XP055178512
STRATAGENE, STRATEGIES, vol. 5, 1992, pages 81
PROC. NATL. ACAD. SCI. U.S.A., vol. 69, 1972, pages 2110
NUCLEIC ACIDS RES., vol. 16, 1988, pages 6127
VAN DER REST ET AL., APPL. MICROBIOL. BIOTECHNOL., vol. 52, 1999, pages 541
PROC. NATL. ACAD. SCI. U.S.A., vol. 74, 1977, pages 5463
W. JAGER ET AL., J. BACTERIOL., vol. 174, 1992, pages 5462
Attorney, Agent or Firm:
SIKs & Co. (JP)
Patent business corporation patent firm Sykes (JP)
Patent business corporation patent firm Sykes (JP)
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