Title:
VACCINE COMPOSITION FOR CHICKENPOX OR VARICELLA ZOSTER AND METHOD OF USING SAME
Document Type and Number:
WIPO Patent Application WO/2022/055176
Kind Code:
A1
Abstract:
The present invention relates to a vaccine composition for chickenpox or varicella zoster, comprising a glycoprotein E (gE) antigen of varicella zoster virus (VZV) and monophosphoryl lipid A (MLA), and to a method of using same. The vaccine composition according to one aspect: can have a significantly improved production yield by comprising a gE antigen comprising an optimized signal peptide sequence, an improved immunogenicity by comprising MLA, and a further enhanced immunogenicity improved with MLA through additionally added saponin such as QS-21; is prepared in the form of CoPoP liposome such that a vaccine antigen can be presented on the surface of the liposome, and the antigen can be better absorbed by antigen-presenting cells; and may have a maximized vaccine efficacy by comprising a vaccine antigen and an adjuvant in one formulation. Therefore, the vaccine composition can be effectively used as an alternative to an existing vaccine for prevention or treatment of varicella-zoster virus infectious diseases.
Inventors:
LEE CHAN KYU (KR)
LOVELL JONATHAN F (CA)
YUN JEE SUN (KR)
KIM SEOK KYU (KR)
LEE BYUNG MAN (KR)
HA DA HUI (KR)
LEE JEONG YOON (KR)
LEE CHOON GEUN (KR)
LEE YE RAM (KR)
HUANG WEI-CHIAO (US)
HAN JEMIN (KR)
LOVELL JONATHAN F (CA)
YUN JEE SUN (KR)
KIM SEOK KYU (KR)
LEE BYUNG MAN (KR)
HA DA HUI (KR)
LEE JEONG YOON (KR)
LEE CHOON GEUN (KR)
LEE YE RAM (KR)
HUANG WEI-CHIAO (US)
HAN JEMIN (KR)
Application Number:
PCT/KR2021/011841
Publication Date:
March 17, 2022
Filing Date:
September 02, 2021
Export Citation:
Assignee:
EUBIOLOGICS CO LTD (KR)
POP BIOTECHNOLOGIES INC (US)
POP BIOTECHNOLOGIES INC (US)
International Classes:
A61K39/25; A61K39/00; A61P31/20
Foreign References:
| KR20070110413A | 2007-11-16 | |||
| US20180085473A1 | 2018-03-29 | |||
| KR20190117462A | 2019-10-16 | |||
| KR102019331B1 | 2019-09-09 | |||
| US10272160B2 | 2019-04-30 |
Other References:
DATABASE PROTEIN 3 February 2012 (2012-02-03), ANONYMOUS : "membrane glycoprotein E [Human alphaherpesvirus 3]", XP055911564, retrieved from NCBI Database accession no. AEW88764
NAJOUA DENDOUGA, FOCHESATO MICHEL, LOCKMAN LAURENCE, MOSSMAN SALLY, GIANNINI SANDRA L.: "Cell-mediated immune responses to a varicella-zoster virus glycoprotein E vaccine using both a TLR agonist and QS21 in mice", VACCINE, ELSEVIER, vol. 30, no. 20, 1 April 2012 (2012-04-01), pages 3126 - 3135, XP055068453, ISSN: 0264410X, DOI: 10.1016/j.vaccine.2012.01.088
SHUAI SHAO, JUMIN GENG, HYUN AH YI, SHOBHIT GOGIA, SRIRAM NEELAMEGHAM, AMY JACOBS, JONATHAN F. LOVELL: "Functionalization of cobalt porphyrin–phospholipid bilayers with his-tagged ligands and antigens", NATURE CHEMISTRY, NATURE PUBLISHING GROUP UK, LONDON, vol. 7, no. 5, London, pages 438 - 446, XP055322711, ISSN: 1755-4330, DOI: 10.1038/nchem.2236
"Genbank", Database accession no. NP_040190.1
BLIGH, E.GDYER, W.J, CAN. J. BIOCHEM. PHYSIOL, vol. 37, 1959, pages 911 - 917
"Goodman And Gilman's: The Pharmacological Bases of Therapeutics", 1990, MACK PUBLISHING CO
NAJOUA DENDOUGA, FOCHESATO MICHEL, LOCKMAN LAURENCE, MOSSMAN SALLY, GIANNINI SANDRA L.: "Cell-mediated immune responses to a varicella-zoster virus glycoprotein E vaccine using both a TLR agonist and QS21 in mice", VACCINE, ELSEVIER, vol. 30, no. 20, 1 April 2012 (2012-04-01), pages 3126 - 3135, XP055068453, ISSN: 0264410X, DOI: 10.1016/j.vaccine.2012.01.088
SHUAI SHAO, JUMIN GENG, HYUN AH YI, SHOBHIT GOGIA, SRIRAM NEELAMEGHAM, AMY JACOBS, JONATHAN F. LOVELL: "Functionalization of cobalt porphyrin–phospholipid bilayers with his-tagged ligands and antigens", NATURE CHEMISTRY, NATURE PUBLISHING GROUP UK, LONDON, vol. 7, no. 5, London, pages 438 - 446, XP055322711, ISSN: 1755-4330, DOI: 10.1038/nchem.2236
"Genbank", Database accession no. NP_040190.1
BLIGH, E.GDYER, W.J, CAN. J. BIOCHEM. PHYSIOL, vol. 37, 1959, pages 911 - 917
"Goodman And Gilman's: The Pharmacological Bases of Therapeutics", 1990, MACK PUBLISHING CO
Attorney, Agent or Firm:
Y.P.LEE, MOCK & PARTNERS (KR)
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