Title:
VACCINE COMPOSITION COMPRISING CAPSULAR POLYSACCHARIDE-PROTEIN CONJUGATE DERIVED FROM SALMONELLA TYPHI
Document Type and Number:
WIPO Patent Application WO/2023/003329
Kind Code:
A1
Abstract:
The present invention relates to a vaccine composition comprising a capsular polysaccharide-protein conjugate derived from Salmonella typhi, wherein the optimal culture conditions for Salmonella typhi growth and Vi capsular polysaccharide expression were established, the purified Vi capsular polysaccharide was conjugated to a conjugate protein to produce a conjugate having a specific average molecular weight, and it was confirmed that a Vi capsular polysaccharide-conjugated protein conjugate of the present invention had excellent immunogenicity. A method for producing the Vi capsular polysaccharide-conjugated protein conjugate of the present invention, and a conjugate produced thereby can be used for the prevention of typhoid.
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Inventors:
YANG SEON-YOUNG (KR)
KIM HUN (KR)
PARK YONGWOOK (KR)
HA KYUNG-HO (KR)
LEE MIN-CHANG (KR)
JUNG JIN-HO (KR)
KIM HUN (KR)
PARK YONGWOOK (KR)
HA KYUNG-HO (KR)
LEE MIN-CHANG (KR)
JUNG JIN-HO (KR)
Application Number:
PCT/KR2022/010548
Publication Date:
January 26, 2023
Filing Date:
July 19, 2022
Export Citation:
Assignee:
SK BIOSCIENCE CO LTD (KR)
International Classes:
A61K39/112; A61K39/00; A61K39/385; A61K47/64; A61P31/04
Foreign References:
| KR20200133398A | 2020-11-27 | |||
| KR20190015641A | 2019-02-13 | |||
| US5204098A | 1993-04-20 | |||
| KR20180011577A | 2018-02-02 |
Other References:
F. MICOLI; S. RONDINI; I. PISONI; C. GIANNELLI; V. DI CIOCCIO; P. COSTANTINO; A. SAUL; L.B. MARTIN;: "Production of a conjugate vaccine for Salmonella enterica serovar Typhi from Citrobacter Vi", VACCINE, ELSEVIER, AMSTERDAM, NL, vol. 30, no. 5, 29 November 2011 (2011-11-29), AMSTERDAM, NL , pages 853 - 861, XP028436164, ISSN: 0264-410X, DOI: 10.1016/j.vaccine.2011.11.108
Attorney, Agent or Firm:
FIRSTLAW P.C. (KR)
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