VACCINES WITH HIGHER CARBOHYDRATE ANTIGEN DENSITY AND NOVEL SAPONIN ADJUVANT

Title:

VACCINES WITH HIGHER CARBOHYDRATE ANTIGEN DENSITY AND NOVEL SAPONIN ADJUVANT

Document Type and Number:

WIPO Patent Application WO/2014/107652

Kind Code:

A3

Abstract:

The present invention provides vaccines comprising carbohydrate antigen conjugated to a diphtheria toxin (DT) as a carrier protein, wherein the ratio of the number of carbohydrate antigen molecule to the carrier protein molecule is higher than 5:1. Also disclosed herein is a novel saponin adjuvant and methods to inhibit cancer cells, by administering an effective amount of the vaccine disclose herein.

Inventors:

TONY YU CHENG DER (US)
LEE WEI HAN (TW)
WANG NAN-HSUAN (TW)
CHANG CHUNG HAO (TW)
HSIEH YIH-HUANG (TW)
WANG CHENG-CHI (TW)
LIN YU-HSIN (TW)
LIN YU-CHEN (TW)
CHEN I-JU (TW)

Application Number:

PCT/US2014/010310

Publication Date:

December 24, 2014

Filing Date:

January 06, 2014

Export Citation:

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Assignee:

OBI PHARMA
TONY YU CHENG DER (US)

International Classes:

C07H15/00; C07K16/00

Domestic Patent References:

WO2011156774A2	2011-12-15
WO1996040242A1	1996-12-19

Foreign References:

US20120328646A1

2012-12-27

Other References: