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Title:
VANILLOID RECEPTOR ANTAGONISTS, AND METHODS OF MAKING AND USING THEM
Document Type and Number:
WIPO Patent Application WO2004103281
Kind Code:
A3
Abstract:
One aspect of the invention relates to antagonists of mammalian vanilloid receptors. Another aspect of the invention relates to a method of modulating the activity of a vanilloid receptor in a mammal, comprising administering a compound of the invention. A third aspect of the invention relates to a method of treating a mammal suffering from pain associated with a malady selected from the group consisting of bladder hyperreflexia, detrusor instability, post-mastectomy pain, mucositis, interstitial cystitis, pharyngitis, pancreatitis, enteritis, cellulitis, postherpetic neuralgia, peripheral neuropathy, arthritis, and bony fractures, comprising administering a compound of the invention.

Inventors:
KOZIKOWSKI ALAN P (US)
BLUMBERG PETER M (US)
Application Number:
US2004014871W
Publication Date:
April 07, 2005
Filing Date:
May 13, 2004
Export Citation:
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Assignee:
UNIV GEORGETOWN (US)
KOZIKOWSKI ALAN P (US)
BLUMBERG PETER M (US)
International Classes:
C07C275/00; C07C335/00; C07C335/12; A61K; (IPC1-7): C07C275/00; C07C335/00
Domestic Patent References:
WO2002016318A12002-02-28
Foreign References:
US4465509A1984-08-14
US6586628B22003-07-01
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