Title:
VARIANT DOMAINS FOR MULTIMERIZING PROTEINS AND SEPARATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/226502
Kind Code:
A3
Abstract:
The current invention relates to means and methods for producing and isolating immunoglobulin proteins comprising a first and a second immunoglobulin polypeptide, in particular to means and methods for producing, and separating proteins comprising said first and second immunoglobulin polypeptide. By including variations to amino acids, and variant separation domains from a cell producing the desired immunoglobulin protein, a desired immunoglobulin protein as produced can be separated from mixtures of immunoglobulin proteins.
Inventors:
DE KRUIF CORNELIS ADRIAAN (NL)
SILVERMAN PETER BRIAN (NL)
BONNEAU RICHARD (NL)
SILVERMAN PETER BRIAN (NL)
BONNEAU RICHARD (NL)
Application Number:
PCT/NL2020/050298
Publication Date:
February 04, 2021
Filing Date:
May 08, 2020
Export Citation:
Assignee:
MERUS NV (NL)
International Classes:
C07K16/00; C07K16/06; C07K16/28; C07K16/36; C07K16/46
Domestic Patent References:
| WO2005092925A2 | 2005-10-06 | |||
| WO2001040306A1 | 2001-06-07 | |||
| WO2017213267A1 | 2017-12-14 | |||
| WO2013055809A1 | 2013-04-18 | |||
| WO2016016299A1 | 2016-02-04 |
Foreign References:
| US7135287B1 | 2006-11-14 | |||
| EP2009101A1 | 2008-12-31 | |||
| EP2202245A1 | 2010-06-30 |
Other References:
CAMILLA DE NARDIS ET AL: "A new approach for generating bispecific antibodies based on a common light chain format and the stable architecture of human immunoglobulin G 1", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 292, no. 35, 1 September 2017 (2017-09-01), US, pages 14706 - 14717, XP055403663, ISSN: 0021-9258, DOI: 10.1074/jbc.M117.793497
Attorney, Agent or Firm:
WITMANS, H.A. (NL)
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