Title:
VMAT2 INHIBITOR AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/027792
Kind Code:
A1
Abstract:
The present invention relates to a class of compounds that serve as VMAT2 inhibitors, and relates in particular to a compound represented by formula (I), or a stereoisomer or pharmaceutically acceptable salt thereof, and a preparation method therefor, as well as an application thereof in the preparation of a medicament for treating diseases related to VMAT2. (I)
Inventors:
TIAN JINGWEI (CN)
ZHANG RUI (CN)
YE LIANG (CN)
YU DAWEI (CN)
DU GUANGYING (CN)
LIU ZONGLIANG (CN)
ZOU FANGXIA (CN)
CUI BO (CN)
ZHANG RUI (CN)
YE LIANG (CN)
YU DAWEI (CN)
DU GUANGYING (CN)
LIU ZONGLIANG (CN)
ZOU FANGXIA (CN)
CUI BO (CN)
Application Number:
PCT/CN2020/108314
Publication Date:
February 18, 2021
Filing Date:
August 11, 2020
Export Citation:
Assignee:
SHANDONG LUYE PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D455/06; A61K31/473; A61P25/14
Domestic Patent References:
| WO2018222549A1 | 2018-12-06 |
Foreign References:
| CN101484190A | 2009-07-15 |
Other References:
HANK F.KUNG ET AL.: "In vivo imaging of vesicular monoamine transporter 2 in pancreas using an 18F epoxide derivative of tetrabenazine transporter 2 in pancreas using an 18F epoxide derivative of tetrabenazine", NUCLEAR MEDICINE AND BIOLOGY, vol. 35, no. 8, 30 November 2008 (2008-11-30), XP025678986, DOI: 10.1016/j.nucmedbio.2008.08.004
HAO XUESHI, JIN QIHUI, VA PORINO, LI CHUN, SHEN WEIJUN, LAFFITTE BRYAN, WU TOM Y.-H.: "Pancreas-Specific Delivery of β-Cell Proliferating Small Molecules", CHEMMEDCHEM, WILEY-VCH, DE, vol. 11, no. 11, 6 June 2016 (2016-06-06), DE, pages 1129 - 1132, XP055780343, ISSN: 1860-7179, DOI: 10.1002/cmdc.201600116
DATABASE REGISTRY ANONYMOUS: "/1 -(C) FILE REGISTRY RN -927182-65-8 REGISTRY ED -Entered STN: 18 Mar 2007 CN -2H-Benzo[a]quinolizin-2-ol, 1,3,4,6,7,11b-hexahydro-10-methoxy-9-(3- methoxypropoxy)-3-(2-methylpropyl)-(CA INDEX NAME)", XP055781055
DATABASE REGISTRY 6 December 2007 (2007-12-06), ANONYMOUS: "2H-Benzo[a]quinolizin-2-ol, 9-[4-(fluoro-18F)butoxy]-1,3,4,6,7,11b- hexahydro-10-methoxy-3-(2-methylpropyl)-, (2R,3R,11bR)-rel- (CA INDEX NAME)", XP055887848, retrieved from STN Database accession no. 956903-28-9
CHENG, Y.PRUSOFF, W.H., BIOCHEM. PHARMACOL., vol. 22, 1973, pages 3099 - 3108
HAO XUESHI, JIN QIHUI, VA PORINO, LI CHUN, SHEN WEIJUN, LAFFITTE BRYAN, WU TOM Y.-H.: "Pancreas-Specific Delivery of β-Cell Proliferating Small Molecules", CHEMMEDCHEM, WILEY-VCH, DE, vol. 11, no. 11, 6 June 2016 (2016-06-06), DE, pages 1129 - 1132, XP055780343, ISSN: 1860-7179, DOI: 10.1002/cmdc.201600116
DATABASE REGISTRY ANONYMOUS: "/1 -(C) FILE REGISTRY RN -927182-65-8 REGISTRY ED -Entered STN: 18 Mar 2007 CN -2H-Benzo[a]quinolizin-2-ol, 1,3,4,6,7,11b-hexahydro-10-methoxy-9-(3- methoxypropoxy)-3-(2-methylpropyl)-(CA INDEX NAME)", XP055781055
DATABASE REGISTRY 6 December 2007 (2007-12-06), ANONYMOUS: "2H-Benzo[a]quinolizin-2-ol, 9-[4-(fluoro-18F)butoxy]-1,3,4,6,7,11b- hexahydro-10-methoxy-3-(2-methylpropyl)-, (2R,3R,11bR)-rel- (CA INDEX NAME)", XP055887848, retrieved from STN Database accession no. 956903-28-9
CHENG, Y.PRUSOFF, W.H., BIOCHEM. PHARMACOL., vol. 22, 1973, pages 3099 - 3108
Download PDF: