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Title:
VMAT2 INHIBITOR AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/027792
Kind Code:
A1
Abstract:
The present invention relates to a class of compounds that serve as VMAT2 inhibitors, and relates in particular to a compound represented by formula (I), or a stereoisomer or pharmaceutically acceptable salt thereof, and a preparation method therefor, as well as an application thereof in the preparation of a medicament for treating diseases related to VMAT2. (I)

Inventors:
TIAN JINGWEI (CN)
ZHANG RUI (CN)
YE LIANG (CN)
YU DAWEI (CN)
DU GUANGYING (CN)
LIU ZONGLIANG (CN)
ZOU FANGXIA (CN)
CUI BO (CN)
Application Number:
PCT/CN2020/108314
Publication Date:
February 18, 2021
Filing Date:
August 11, 2020
Export Citation:
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Assignee:
SHANDONG LUYE PHARMACEUTICAL CO LTD (CN)
International Classes:
C07D455/06; A61K31/473; A61P25/14
Domestic Patent References:
WO2018222549A12018-12-06
Foreign References:
CN101484190A2009-07-15
Other References:
HANK F.KUNG ET AL.: "In vivo imaging of vesicular monoamine transporter 2 in pancreas using an 18F epoxide derivative of tetrabenazine transporter 2 in pancreas using an 18F epoxide derivative of tetrabenazine", NUCLEAR MEDICINE AND BIOLOGY, vol. 35, no. 8, 30 November 2008 (2008-11-30), XP025678986, DOI: 10.1016/j.nucmedbio.2008.08.004
HAO XUESHI, JIN QIHUI, VA PORINO, LI CHUN, SHEN WEIJUN, LAFFITTE BRYAN, WU TOM Y.-H.: "Pancreas-Specific Delivery of β-Cell Proliferating Small Molecules", CHEMMEDCHEM, WILEY-VCH, DE, vol. 11, no. 11, 6 June 2016 (2016-06-06), DE, pages 1129 - 1132, XP055780343, ISSN: 1860-7179, DOI: 10.1002/cmdc.201600116
DATABASE REGISTRY ANONYMOUS: "/1 -(C) FILE REGISTRY RN -927182-65-8 REGISTRY ED -Entered STN: 18 Mar 2007 CN -2H-Benzo[a]quinolizin-2-ol, 1,3,4,6,7,11b-hexahydro-10-methoxy-9-(3- methoxypropoxy)-3-(2-methylpropyl)-(CA INDEX NAME)", XP055781055
"CAS RN:956903-28-9", STN-REGISTRY, 6 December 2007 (2007-12-06), DOI: 20200928103156X
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