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Title:
WATER-SOLUBLE CHITOSAN ANTIMICROBIAL DERIVATIVE AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2019/052321
Kind Code:
A1
Abstract:
Disclosed in the present invention are a water-soluble chitosan antimicrobial derivative and a preparation method therefor. The water-soluble chitosan antimicrobial derivative comprises chitosan frameworks and dual-function groups for modifying amino groups on the chitosan frameworks, and the dual-function groups are guanidine groups and carbonyl methoxy polyethylene glycol. In the present invention, guanidine groups and short-chain polyethylene glycol are modified on side chains of the chitosan at the same time, and a good antimicrobial function and higher biological safety are brought to the chitosan. In the preparation method in the present invention, chitosan reacts with carbonyl methoxy polyethylene glycol first, so that the water solubility of the chitosan is fully improved, and the biological safety is greatly improved; then, a reaction with thiourea trioxide is carried out, so that graft guanidine groups in the first step are avoided, and amino groups participate in subsequence reactions, it is effectively ensured that guanidine groups have rich positive charges and the positive charge density in the water-soluble chitosan antimicrobial derivative is ensured, and accordingly, antimicrobial performance of the water-soluble chitosan antimicrobial derivative is better.

Inventors:
NIU ZHONGWEI (CN)
ZHU MENG (CN)
JIANG SHIDONG (CN)
Application Number:
PCT/CN2018/101849
Publication Date:
March 21, 2019
Filing Date:
August 23, 2018
Export Citation:
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Assignee:
TECHNICAL INST OF PHYSICS AND CHEMISTRY OF THE CHINESE ACADEMY OF SCIENCES (CN)
International Classes:
C08B37/08
Domestic Patent References:
WO2004073034A22004-08-26
WO2010021930A12010-02-25
Foreign References:
CN101033264A2007-09-12
Attorney, Agent or Firm:
BEIJING JANLEA PATENT AGENCY CO., LTD. (CN)
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