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Title:
WATER SOLUBLE O-GLYCOSYL FLAVONOID COMPOSITIONS AND METHODS FOR PREPARING SAME
Document Type and Number:
WIPO Patent Application WO/2021/079579
Kind Code:
A1
Abstract:
A water-soluble composition including an O-glycosyl flavonoid compound, L-arginine, a sugar alcohol, and ascorbic acid or an alkali salt of ascorbic acid. The O-glycosyl flavonoid compound is rutin, isoquercitrin, or hesperidin, and a molar ratio between the O-glycosyl flavonoid compound and the sugar alcohol is 1:4.0-12.0. Also provided is a method for making the above-described water-soluble composition by combining the O-glycosyl flavonoid compound, L-arginine, the sugar alcohol, and ascorbic acid or an alkali salt thereof to form a mixture, and heating it at 110 oC-140 oC to melt the mixture.

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Inventors:
YAMAGUCHI NAOTO (JP)
SUDAKA YUI (JP)
ONO MITSUNORI (JP)
Application Number:
PCT/JP2020/028322
Publication Date:
April 29, 2021
Filing Date:
July 21, 2020
Export Citation:
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Assignee:
ALPS PHARMACEUTICAL IND CO LTD (JP)
International Classes:
A61K47/18; A61K31/7048; A61K47/26
Domestic Patent References:
WO2010029913A12010-03-18
WO2019208574A12019-10-31
WO2019230013A12019-12-05
Foreign References:
RU2545905C12015-04-10
DE202008006741U12009-10-01
JP2015181399A2015-10-22
JP2015208241A2015-11-24
Other References:
See also references of EP 4048312A4
Attorney, Agent or Firm:
TAKAOKA Ryoichi et al. (JP)
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