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Patent Searching and Data


Title:
X-RAY SENSITIVE STAIN FOR TEETH FRACTURE DETECTION
Document Type and Number:
WIPO Patent Application WO/2021/107825
Kind Code:
A1
Abstract:
This invention relies on a staining solution that contains methylene blue and a metal oxide compound as a radio-opacifier to allow physical and radiographic detection of teeth fracture.

Inventors:
ALJARBOU FAHD (SA)
Application Number:
PCT/SA2020/000009
Publication Date:
June 03, 2021
Filing Date:
August 12, 2020
Export Citation:
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Assignee:
ALJARBOU FAHD (SA)
International Classes:
A61K6/25; A61K6/65; A61K6/78
Foreign References:
US6387981B12002-05-14
US5415547A1995-05-16
US20150047531A12015-02-19
Other References:
F. M. COLLARES, F. A. OGLIARI, G. S. LIMA, V. R. C. FONTANELLA, E. PIVA, S. M. W. SAMUEL: "Ytterbium trifluoride as a radiopaque agent for dental cements : Ytterbium trifluoride for dental cements", INTERNATIONAL ENDODONTIC JOURNAL, ACKWELL SCIENTIFIC PUBLICATIONS, OXFORD, BL, vol. 43, no. 9, 23 September 2010 (2010-09-23), BL, pages 792 - 797, XP055753037, ISSN: 0143-2885, DOI: 10.1111/j.1365-2591.2010.01746.x
MATHUR RACHIT: "Evaluation of Coronal Leakage Following Different Obturation Techniques and in-vitro Evalution Using Methylene Blue Dye Preparation", JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 1 January 2015 (2015-01-01), XP055815678, ISSN: 2249-782X, DOI: 10.7860/JCDR/2015/15796.6931
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Claims:

1- Use of a stain solution applied physically to detect the teeth fractures and cracks.

2- The stain solution contains methylene blue and a metal oxide radio- opacifier compound

Description:
X-ray sensitive stain for teeth fracture detection

Dental patients visit the dentist for various types of complaints. One of the most difficult complain to be detected is tooth fracture. Usually, dentists take an X-ray radiograph for the offending tooth to search for that crack but unfortunately, most teeth fracture are not identified in this technique. 5 Dentists usually need a more confirmative way of fracture detection and they go for a surgical approach which will necessitate opening a flap and stains the tooth directly to visualize the fracture and confirm the diagnosis.

On of the main stains used in dentistry is methylene blue, which can 10 penetrate gaps efficiently and check marginal seal as seen in the Espacenet patent number ( UA70147 (U) - 2012-05-25) which used to indicate the filling seal quality by measuring the stain depth and that will help for laboratory experiments. Another patent used to detect caries as numbered ( CN101184533B from China 2012-1107) which uses the stain to measure 15 the time spent before the color change and thus will detect the carious from non-carious lesion.

The specific use of the methylene blue for direct visualization of teeth fracture has no patent registered and even though this technique will be 20 limited to the surgical approach and will provide no benefit in terms of X- ray radiographic approach of teeth fracturediagnosis.

The aim of this invention is to make detection of teeth fractures an easier process by increasing its detectability when the radiographic (X-ray) 5 approach is used. This could help patient avoiding the more aggressive approach of oral surgery and it adds benefits for an advanced radiographic machine like a cone beam computed tomography (CBCT) which is commonly used for this purpose. The invention is based on a stain that still keeps the direct visualization 10 approach possible but adds more benefits in terms of clinical diagnosis. This stain contains a radio-opacifier for radiographic detectability and thus will provide the abovementioned important benefits.

The solution made of two main components which are: A- stain in a 15

.carrier B- radio-opacifier

A- Stain in a carrier: 1-15% Methylthioninium chloride in water or alcohol carrier to form a deep blue color. The molecular formula of the stain is C16H18N3SCI. 3H20. The approximate dimensions of the monomer 20 molecule are 1.25 to 1.60 NM long by 0.57 to 0.84 nm wide with a

.thickness of about 0.5 nm B- Radio-opacifier: metal oxide like Bismuth Oxide Nanoparticles compound (BΪ203). Nanoscale Bismuth Oxide Particles are typically 20- 80 nanometers (nm) with specific surface area (SSA) in the 10 - 50 m2/g range and also available with an average particle size of 100 nm range

.with a specific surface area of approximately 7- 10 m2/g 5

The mixed solution is brushed directly on the fracture or crack before X- ray exposure to see them on the radiograph and then a clinical decision is ready to be made.