Title:
XYLAN-BASED DOUBLE NETWORK NANOCOMPOSITE HYDROGEL AND PREPARATION AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/036025
Kind Code:
A1
Abstract:
The present invention belongs to the technical field of composite materials, and disclosed are a xylan-based double network nanocomposite hydrogel and the preparation and application thereof. The method includes: (1) adding a graphite oxide powder into deionized water, and ultrasonically dispersing to obtain a GO water dispersion; (2) adding xylan into deionized water, heating and stirring to obtain a xylan solution; (3) adding a water-soluble calcium salt, a reaction monomer and the xylan solution into the GO water dispersion, stirring and dispersing uniformly under an ice-bath condition, adding an initiator, a cross-linking agent and an accelerator, and stirring to mix well so as to obtain a mixed solution; (4) subjecting the mixed solution of step (3) to a drying reaction, to obtain the xylan based double network nanocomposite hydrogel. The composite hydrogel obtained in the present invention has high mechanical properties, is biodegradable and has good biocompatibility. The present invention is applicable in the field of biomedicine, such as tissue engineering, drug sustained-release, cell culture scaffold and cartilage tissue, etc.
Inventors:
REN JUNLI (CN)
KONG WEIQING (CN)
SUN RUNCANG (CN)
HUANG DANYANG (CN)
XU GUIBIN (CN)
KONG WEIQING (CN)
SUN RUNCANG (CN)
HUANG DANYANG (CN)
XU GUIBIN (CN)
Application Number:
PCT/CN2016/109906
Publication Date:
March 01, 2018
Filing Date:
December 14, 2016
Export Citation:
Assignee:
UNIV SOUTH CHINA TECH (CN)
International Classes:
A61K47/32; C08F251/00; A61K47/36; A61L27/44; A61L27/52; A61L27/58; C08F2/44; C08F220/56; C08F222/38; C08K3/04; C08K3/16
Domestic Patent References:
| WO2012127119A2 | 2012-09-27 |
Foreign References:
| CN105461859A | 2016-04-06 |
Attorney, Agent or Firm:
GUANGZHOU HUAXUE INTELLECTUAL PROPERTY AGENCY CO., LTD (CN)
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