Title:
YAP INHIBITION FOR WOUND HEALING
Document Type and Number:
WIPO Patent Application WO/2021/021607
Kind Code:
A3
Abstract:
Methods of promoting healing of a wound in a dermal location of a subject are provided. Aspects of the methods may include administering an effective amount of a YAP inhibitor composition to the wound to modulate mechanical activation of Engrailed-1 lineage-negative fibroblasts (ENFs) in the wound to promote ENFmediated healing of the wound. Also provided are methods of preventing scarring during healing of a wound in a subject and methods of promoting hair growth on a subject. Aspects of the methods may include forming a wound in a dermal location of a subject and administering an effective amount of a YAP inhibitor composition to the wound to modulate mechanical activation of Engrailed-1 lineage-negative fibroblasts (ENFs) in the wound to promote ENF-mediated healing of the wound. Also provided are kits including an amount of a YAP inhibitor composition and a tissue disrupting device.
Inventors:
MASCHARAK SHAMIK (US)
DESJARDINS-PARK HEATHER ELIZABETH (US)
BORRELLI MIMI (US)
DAVITT MICHAEL FRANCIS (US)
LONGAKER MICHAEL T (US)
DESJARDINS-PARK HEATHER ELIZABETH (US)
BORRELLI MIMI (US)
DAVITT MICHAEL FRANCIS (US)
LONGAKER MICHAEL T (US)
Application Number:
PCT/US2020/043420
Publication Date:
April 08, 2021
Filing Date:
July 24, 2020
Export Citation:
Assignee:
UNIV LELAND STANFORD JUNIOR (US)
MASCHARAK SHAMIK (US)
DESJARDINS PARK HEATHER ELIZABETH (US)
BORRELLI MIMI (US)
DAVITT MICHAEL FRANCIS (US)
LONGAKER MICHAEL T (US)
MASCHARAK SHAMIK (US)
DESJARDINS PARK HEATHER ELIZABETH (US)
BORRELLI MIMI (US)
DAVITT MICHAEL FRANCIS (US)
LONGAKER MICHAEL T (US)
International Classes:
A61K31/409; A61K31/44; A61K31/445; A61K38/00; A61N1/30; A61N5/06
Domestic Patent References:
| WO2018069885A1 | 2018-04-19 |
Foreign References:
| US20110217269A1 | 2011-09-08 | |||
| US20150157584A1 | 2015-06-11 |
Other References:
MASCHARAK ET AL.: "Inhibition of Mechanotransduction Yields Regenerative Wound Healing by Engrailed1-negative Fibroblasts", PLASTIC SURGERY RESEARCH COUNCIL. 64TH ANNUAL MEETING, 2 May 2019 (2019-05-02), XP055811447, Retrieved from the Internet [retrieved on 20200915]
YOKOYAMA ET AL.: "Setting up the dermis for scar-free healing", NAT CELL BIOL., vol. 20, no. 4, 2018, pages 365 - 366, XP036509986, DOI: 10.1038/s41556-018-0080-9
RINKEVICH ET AL.: "Identification and isolation of a dermal lineage with intrinsic fibrogenic potential", SCIENCE, vol. 348, no. 6232, 2015, pages aaa2151, XP055558772, DOI: 10.1126/science.aaa2151
MARSHALL ET AL.: "Cutaneous Scarring: Basic Science, Current Treatments, and Future Directions", ADV WOUND CARE (NEW ROCHELLE, vol. 7, no. 2, 1 February 2018 (2018-02-01), pages 29 - 45, XP055811448
JIANG ET AL.: "Scars or Regeneration? - Dermal Fibroblasts as Drivers of Diverse Skin Wound Responses", LNT J MOL SCI., vol. 21, no. 2, 17 January 2020 (2020-01-17), pages 617, XP055811450
YOKOYAMA ET AL.: "Setting up the dermis for scar-free healing", NAT CELL BIOL., vol. 20, no. 4, 2018, pages 365 - 366, XP036509986, DOI: 10.1038/s41556-018-0080-9
RINKEVICH ET AL.: "Identification and isolation of a dermal lineage with intrinsic fibrogenic potential", SCIENCE, vol. 348, no. 6232, 2015, pages aaa2151, XP055558772, DOI: 10.1126/science.aaa2151
MARSHALL ET AL.: "Cutaneous Scarring: Basic Science, Current Treatments, and Future Directions", ADV WOUND CARE (NEW ROCHELLE, vol. 7, no. 2, 1 February 2018 (2018-02-01), pages 29 - 45, XP055811448
JIANG ET AL.: "Scars or Regeneration? - Dermal Fibroblasts as Drivers of Diverse Skin Wound Responses", LNT J MOL SCI., vol. 21, no. 2, 17 January 2020 (2020-01-17), pages 617, XP055811450
Attorney, Agent or Firm:
FIELD, Bret E. (US)
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