Title:
ZIKA VIRUS VIRUS LIKE PARTICLE
Document Type and Number:
WIPO Patent Application WO/2017/150683
Kind Code:
A1
Abstract:
Provided is a virus like particle comprising one or more zika virus structural proteins, and a composition or vaccine comprising thereof, its use in the prevention or treatment of zika virus disease. The zika virus structural protein contains at least one amino acid alteration in the envelope protein.
Inventors:
AKAHATA WATARU (US)
UENO RYUJI (US)
UENO RYUJI (US)
Application Number:
PCT/JP2017/008338
Publication Date:
September 08, 2017
Filing Date:
March 02, 2017
Export Citation:
Assignee:
VLP THERAPEUTICS LLC (US)
AKAHATA WATARU (US)
UENO RYUJI (US)
AKAHATA WATARU (US)
UENO RYUJI (US)
International Classes:
C12N7/04; A61K35/76; A61P31/14; C12N15/00
Domestic Patent References:
| WO2015139784A1 | 2015-09-24 | |||
| WO2016021209A1 | 2016-02-11 | |||
| WO2016210127A1 | 2016-12-29 | |||
| WO2016199936A1 | 2016-12-15 | |||
| WO2017015463A2 | 2017-01-26 | |||
| WO2017009873A1 | 2017-01-19 |
Foreign References:
| CN106085974A | 2016-11-09 |
Other References:
KONISHI E. ET AL., vol. 26, 2015, pages 27 - 36
DATABASE Nucleotide [O] 23 November 2010 (2010-11-23), "Zika virus strain MR 766, complete genome", XP055421646, Database accession no. AY632535.2
COX B.D. ET AL.: "Predicting Zika virus structural biology: Challenges and opportunities for intervention", ANTIVIRAL CHEMISTRY AND CHEMOTHERAPY, vol. 24, no. 3-4, 2015, pages 118 - 126, XP055328128
YAMAJI H. ET AL.: "Efficient production of Japanese encephalitis virus-like particles by recombinant lepidopteran insect cells.", APPL. MICROBIOL. BIOTECHNOL., vol. 97, 2013, pages 1071 - 1079, XP055402222
HSIEH SZU-CHIA ET AL.: "The Length of and Nonhydrophobic Residues in the Transmembrane Domain of Dengue Virus Envelope Protein Are Critical for Its Retention and Assembly in the Endoplasmic Reticulum .", J. VIROL., vol. 84, no. 9, 2010, pages 4782 - 4797, XP055421654
CHAROENSRI N. ET AL.: "An optimized expression vector for improving the yield of dengue virus-like particles from transfected insect cells", JOURNAL OF VIROLOGICAL METHODS, vol. 205, 2014, pages 116 - 123, XP055421659
PURDY D.E. ET AL.: "Secretion of noninfectious dengue virus-like particles and identification of amino acids in the stem region involved in intracellular retention of envelope protein", VIROLOGY, vol. 333, 15 March 2005 (2005-03-15), pages 239 - 250, XP004757140
RICHNER J.M. ET AL.: "Modified mRNA Vaccines Protect against Zika Virus Infection", CELL, vol. 168, 17 February 2017 (2017-02-17), pages 1114 - 1125, XP055370676
TAYLOR T.J. ET AL.: "Production of immunogenic West Nile virus-like particles using a herpes simplex virus 1 recombinant vector", VIROLOGY, vol. 496, 20 June 2016 (2016-06-20), pages 186 - 193, XP029666781, DOI: doi:10.1016/j.virol.2016.06.006
DATABASE Nucleotide [O] 23 November 2010 (2010-11-23), "Zika virus strain MR 766, complete genome", XP055421646, Database accession no. AY632535.2
COX B.D. ET AL.: "Predicting Zika virus structural biology: Challenges and opportunities for intervention", ANTIVIRAL CHEMISTRY AND CHEMOTHERAPY, vol. 24, no. 3-4, 2015, pages 118 - 126, XP055328128
YAMAJI H. ET AL.: "Efficient production of Japanese encephalitis virus-like particles by recombinant lepidopteran insect cells.", APPL. MICROBIOL. BIOTECHNOL., vol. 97, 2013, pages 1071 - 1079, XP055402222
HSIEH SZU-CHIA ET AL.: "The Length of and Nonhydrophobic Residues in the Transmembrane Domain of Dengue Virus Envelope Protein Are Critical for Its Retention and Assembly in the Endoplasmic Reticulum .", J. VIROL., vol. 84, no. 9, 2010, pages 4782 - 4797, XP055421654
CHAROENSRI N. ET AL.: "An optimized expression vector for improving the yield of dengue virus-like particles from transfected insect cells", JOURNAL OF VIROLOGICAL METHODS, vol. 205, 2014, pages 116 - 123, XP055421659
PURDY D.E. ET AL.: "Secretion of noninfectious dengue virus-like particles and identification of amino acids in the stem region involved in intracellular retention of envelope protein", VIROLOGY, vol. 333, 15 March 2005 (2005-03-15), pages 239 - 250, XP004757140
RICHNER J.M. ET AL.: "Modified mRNA Vaccines Protect against Zika Virus Infection", CELL, vol. 168, 17 February 2017 (2017-02-17), pages 1114 - 1125, XP055370676
TAYLOR T.J. ET AL.: "Production of immunogenic West Nile virus-like particles using a herpes simplex virus 1 recombinant vector", VIROLOGY, vol. 496, 20 June 2016 (2016-06-20), pages 186 - 193, XP029666781, DOI: doi:10.1016/j.virol.2016.06.006
Attorney, Agent or Firm:
SAMEJIMA, Mutsumi et al. (JP)
Download PDF: