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Title:
A dTDP-β-D-FUCOFURANOSE, ITS PREPARATION METHOD AND USE
Document Type and Number:
WIPO Patent Application WO/2009/030073
Kind Code:
A1
Abstract:
Provided is a dTDP-β-D-fucofuranose, which is also referred to as dTDP-β-6-deoxy-D-galactofuranose. The dTDP-β-D-fucofuranose is synthesized by using reductase Fcf1 and mutase Fcf2 in the gram-negative bacteria. Also provided are the preparation method of the dTDP-β-D-fucofuranose and use of the dTDP-β-D-fucofuranose for manufacturing a medicament for the treatment of tumor.

Inventors:
WANG LEI (CN)
WANG QUAN (CN)
FENG LU (CN)
Application Number:
PCT/CN2007/002721
Publication Date:
March 12, 2009
Filing Date:
September 14, 2007
Export Citation:
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Assignee:
TIANJIN BIOCHIP CORP (CN)
WANG LEI (CN)
WANG QUAN (CN)
FENG LU (CN)
International Classes:
C07H15/04; A61K31/7024; A61P35/00; C12P19/26
Foreign References:
Other References:
FENG, L. ET AL.: "Synthesis of the Heteropolysaccharide O Antigen of Escherichia coli 052 Requires an ABC Transporter: Structural and Genetic Evidence.", JOURNAL OF BACTERIOLOGY, vol. 186, no. 14, July 2004 (2004-07-01), pages 4510 - 4519, XP055353214, ISSN: 0021-9193
ZAYNI, S. ET AL.: "The dTDP-4-dehydro-6-deoxyglucose reductase encoding fcd gene is part of the surface layer glycoprotein glycosylation gene cluster of Geobacillus tepidamans GSS-97T.", GLYCOBIOLOGY, vol. 17, no. 4, 3 January 2007 (2007-01-03), pages 433 - 443, XP055353216, ISSN: 0959-6658
FISHER, C. ET AL.: "The Complete Gene Cluster of the Antitumor Agent Gilvocarcin V and Its Implication for the Biosynthesis of the Gilvocarcins.", J. AM. CHEM. SOC., vol. 125, no. 26, 6 October 2003 (2003-10-06), pages 7818 - 7819, XP055353219, ISSN: 0002-7863
DATABASE GenBank [O] 6 February 2006 (2006-02-06), FENG,L.: "Escherichia coli O52 O-antigen gene cluster, partial sequence", XP055353476, retrieved from ncbi Database accession no. AY528413
DATABASE protein [O] 6 February 2006 (2006-02-06), FENG,L: "Fcf1 [Escherichia coli]", XP055353478, retrieved from ncbi Database accession no. AAS99161
DATABASE protein [O] 6 February 2006 (2006-02-06), FENG,L.: "Fcf2 [Escherichia coli]", XP055353479, retrieved from ncbi Database accession no. AAS99162
Attorney, Agent or Firm:
LIAN & LIEN IP ATTORNEYS (TowerA Huaxin Building, No.33Anding Road, Chaoyan, Beijing 9, CN)
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