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WO/1999/060051A2 |
Novel manufactures are provided having surfaces which upon contact with water promptly provide for high and permanent lubricity. The surfaces involve a carboxylic acid functionality which at least in part is present as an ester and/or am...
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WO/1999/052946A1 |
The invention concerns a method for preparing native collagen, comprising pretreatment of the collagen in a mixer with double transverse cutters equipped with a system controlling agitating and shearing velocity and a thermostat, and a s...
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WO/1999/052962A1 |
A multidimensional copolymer array of a plurality of copolymers, polymerized from at least two independently variable sets of monomers, is created. The homologous variations of the monomer series are selected to determine the effect of v...
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WO/1999/049907A1 |
Medical devices are provided, at least part of the surface of which a protein having the activity of Protein C or Activated Protein C is directly or indirectly attached. The devices of the invention may be vascular prostheses such as ste...
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WO/1999/043364A1 |
A synthetic absorbable monofilament (16) comprising a glycolide, and an epsilon caprolactone is provided. The monofilament (16) exhibits physical characteristics equivalent to or superior than gut sutures. The monofilaments (16) can be f...
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WO/1999/038544A2 |
Medical articles can include biocompatible material with a deposit of anticalcific elemental metal. The biocompatible material can be tissue, fabric or the like. The biocompatible material can be configured on the medical article such th...
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WO/1999/032536A1 |
Biocompatible polyhydroxyalkanoate compositions, particularly based on biotechnologically produced homo- and copolymers of 4- hydroxybutyric acid, with controlled degradation rates have been developed. In one embodiment, the polyhydroxya...
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WO/1999/026665A2 |
A method of forming a reticulated coating on a substrate, comprising providing an agglomerate dispersion of a first polymer in a polar liquid carrier on a surface of the substrate, and evaporating the liquid carrier to form the coating.
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WO/1999/024107A1 |
A polymer with a hydrolytically labile backbone and having structure (VIII) wherein R¿9? is an alkyl, aryl or alkylaryl group with up to 18 carbon atoms having a pendent carboxylic acid group or the benzyl ester thereof; R¿12? is an al...
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WO/1999/024106A1 |
A drug-infusing device is implanted into a body cavity such as a bladder. The device is implanted in an uninflated, low profile state. After insertion into the body cavity, the device is filled with a substance, such as a drug, and assum...
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WO/1999/021487A1 |
A device (1) for use in conjunction with a surgical stitch-forming device whereby suture material (7) is fed through a housing (3) from a rotatable suture driver member (2) within the housing. The suture drive member (2) includes a sutur...
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WO/1999/020328A2 |
A dispenser in which a dry powder (one component of a two-part adhesive tissue sealant) is stored in a container (e.g., a carpule) having a septum at one end, an open end opposite the septum, and a movable plug. The powder is retained at...
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WO1998044021A9 |
Biodegradable terephthalate polymers are described comprising the recurring monomeric units shown in formula (I): wherein R is a divalent organic moiety; R' is an aliphatic, aromatic or heterocyclic residue; x is >/= 1; and n is 0-5,000,...
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WO/1999/017814A1 |
Disclosed are biocompatible prepolymer compositions comprising a compatible antimicrobial agent and, in particular, a compatible iodine containing antimicrobial agent. These compositions provide for $i(in situ) formation of an antimicrob...
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WO/1999/015209A2 |
The invention relates to a fibrin sponge comprising a residual moisture content of at least 3 %, preferably of 3 to 35 %, in particular 10 to 20 %, and preferably containing a blood clotting activator or proactivator, a method of prepari...
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WO/1999/009891A1 |
This invention is a fused loop (10) of an elongated material such as a surgical suture, and apparatus for making the loop. Portions of one or more segments (12) to be joined together are fused in a welding process to form a welded joint ...
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WO/1998/055527A1 |
The invention relates to biodegradable linear polyester urethanes and to biodegradable cross-linked polyester urethanes obtained from linear polyester urethanes by virtue of the fact that they are cross-linked by diisocyanate bridges. By...
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WO/1998/051246A1 |
An analgesic agent delivery system and method of treating postoperative pain comprising an analgesic agent such as morphine and an extended-release drug delivery device (31). The device (62) may be placed in the vicinity of a wound (61) ...
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WO/1998/051812A2 |
Polyhydroxyalkanoates (PHAs) from which pyrogen has been removed are provided for use in numerous biomedical applications. PHAs which have been chemically modified to enhance physical and/or chemical properties, for targeting or to modif...
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WO/1998/049202A1 |
Disclosed and claimed are: a composition including at least one glycosaminoglycan, e.g., CIS, and at least one alginate, e.g., sodium alginate, wherein: the at least one glycosaminoglycan and/or the algninate are cross-linked or polymeri...
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WO/1998/047432A1 |
A radioactive suture for inhibiting an intimal hyperplastic response comprises a needle and a suture material having a radioactive beta-emitting element. This radioactive element is preferably chemically bonded to an organic substrate of...
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WO/1998/046165A1 |
The present invention relates, in general, to tissue decellularization and, in particular to a method of treating tissues, for example, heart valves, tendons and ligaments, so as to render them acellular and thereby limit mineralization ...
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WO/1998/046286A1 |
Biodegradable polymers are described comprising the recurring monomeric units shown in formula (I), wherein R is selected from the group consisting of H, alkyl, aryl or heterocyclic; and R' is selected from the group consisting of H, alk...
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WO/1998/044020A1 |
Biodegradable polymers are described comprising the recurring monomeric units shown in formula (I) or (II) wherein X is -O- or -NR'-, where R' is H or alkyl; L is a branched or straight chain aliphatic group having from 1-20 carbon atoms...
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WO/1998/042451A1 |
A method for coating surgical fibers and surgical braids employing dual capillaries (10) in series. After the fiber (50) or braid is initially coated with a t-guide capillary (16), the fiber (50) or braid is dried using forced air within...
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WO/1998/041095A2 |
Multilayer anti-microbial materials formed to produce an interference colour, and thus an indicator of anti-microbial effect, are provided. The materials include a partly reflective base layer and a partly reflective, partly transmissive...
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WO/1998/036013A1 |
Dihydroxy monomer compounds having formula (1) wherein R�1? and R�2? are independently selected from hydrogen or straight or branched alkyl groups having up to 18 carbon atoms; R�3? is selected from -CH=CH- and (-CH�2?-)�k?, wh...
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WO/1998/032398A1 |
Degradable polyesteramide suitable for use in biomedical applications is obtained by reacting diamino alkyl ester with alpha hydroxy acid to form diamide-diol which is reacted with acyl halide or dicarboxylic acid to yield polyesteramide.
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WO/1998/032778A1 |
Cyclic monomers prepared by novel methods are useful in making polyesteramides which can be made into shaped articles, particularly, shaped articles suitable for use as surgical devices.
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WO/1998/032779A1 |
A polyesteramide suitable for use in the fabrication of absorbable surgical devices such as monofilament and multifilament sutures, films, sheets, plates, clips, staples, pins, screws, and the like, is obtained by reacting a monoalkanola...
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WO/1998/032777A1 |
Polyesteramides having amino acid-derived groups alternating with hydroxy acid-derived groups are useful in making shaped articles, particularly, shaped articles suitable for use as surgical devices.
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WO/1998/031735A1 |
The present invention is an improved composition suitable for use as a surgical suture material. The composition comprises the addition of a branched chain polyolefin wax to typical extrusion grade polypropylene suitable for surgical app...
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WO/1998/030090A1 |
Disclosed are cyanoacrylate compositions comprising a compatible antimicrobial agent and, in particular, a compatible iodine containing antimicrobial agent. These compositions provide for $i(in situ) formation of an antimicrobial polymer...
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WO/1998/030092A1 |
Antimicrobial cyanoacrylate compositions are applied to suturable wound surfaces to close the wound surface.
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WO/1998/025974A1 |
The present invention relates to an improved packaging composition comprising an ethylene copolymer selected from ethylene acid or ester copolymers such as ethylene vinyl acetate, ethylene/acrylic acid or methacrylic acid copolymers whic...
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WO/1998/020190A1 |
An implantable medical article as well as an implantable fiber which is particularly useful for medical implants is disclosed. The fiber comprises a first component formed from a substantially resorbable material and a second component f...
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WO/1998/008876A1 |
The application discloses esters of hyaluronic acid, wherein a first part of the carboxy functions is esterified with an araliphatic alcohol and a second part is esterified with long-chain, straight aliphatic alcohols with between 10 and...
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WO/1998/000065A1 |
Absorbable mixtures are fabricated from a predominant component of fatty acid ester mixed with a copolymer comprising a predominant amount of epsilon-caprolactone and a minor amount of at least one other copolymerizable monomer of other ...
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WO/1997/047254A1 |
The present invention provides compositions and methods for coating medical devices with pharmaceutical agents and devices coated with the compositions. The coated devices provide controlled or sustained release of pharmaceutical agents ...
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WO/1997/041901A1 |
A pentosanpolysulfate coating on medical devices reduces or eliminates side effects associated with the introduction of foreign bodies into the urinary tract of a patient. The pentosanpolysulfate coating attenuates the attachment of salt...
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WO/1997/040775A1 |
A dental floss article is provided comprising a fiber having a predetermined length and defined by at least one substantially rigid portion and at least one flexible portion.
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WO/1997/038729A1 |
The present invention relates to an i(in vivo) method for specific targeting and transfer of DNA into mammalian repair cells. The transferred DNA may include any DNA encoding a therapeutic protein of interest. The invention is based on t...
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WO/1997/036553A1 |
Crystalline copolymers of glycolide and optically inactive dl-lactide comprising sixty-two weight percent or less glycolide, methods of producing the same and absorbable medical devices manufactured therefrom having improved properties a...
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WO/1997/032614A1 |
The present invention provides surgical article and suture coated with bioabsorbable microdispersions which contains a fluid carrier that is a liquid polymer and a particulate material.
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WO/1997/024078A1 |
An elongate PTFE (polytetrafluoroethylene) element is formed, having a PTFE matrix and containing a water soluble additive material in the form of solid particles distributed within the matrix. The PTFE elements may be twisted or untwist...
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WO/1997/016545A1 |
Methods and support systems are provided for modifying the regeneration, differentiation, or function of cells. In one embodiment, electrically conducting biocompatible polymers may be used alone or in combination with a polymeric suppor...
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WO/1997/007833A2 |
New biomaterials essentially constituted by esterified derivatives of hyaluronic acid or by cross-linked derivatives of hyaluronic acid for use in the surgical sector, particularly for use in the prevention of post-surgical adhesions.
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WO/1997/003563A1 |
A synergistic fungicidal composition including a strobilurine analogue compound of formula (I), wherein A is the nitrogen atom of group -CH, B is a -OCH2-, -CH20-, -CH(CH3)-O-N=CH- or -CH=N-O-CH(CH3)- group or a group (a), R1 is a C1-4 a...
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WO/1997/002038A1 |
The present invention relates to pharmaceutical compositions which are photostable and antimicrobially active comprising one or more medicinal agents and a stabilized ionized silver-based antimicrobial composition. The stabilized ionized...
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WO/1996/037519A1 |
A polysaccharide hydrogel material consisting of a crosslinked product of a functionalized derivative of alginic acid or hyaluronic acid, whose carboxylic groups are partially esterified with an unsaturated aliphatic or an araliphatic al...
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