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Matches 1 - 50 out of 3,385

Document Document Title
WO/2020/191348A1
Therapeutics targeting the bacterium Porphyromonas gingivalis, including its proteases arginine gingipain A and arginine gingipain B, are disclosed, as well as the use thereof for the treatment of disorders associated with P. gingivalis ...  
WO/2020/184797A1
The present invention relates to: an eco-friendly method capable of synthesizing an unnatural amino acid-based antibacterial and antibiotic preservative, which has excellent antibacterial and antibiotic performance, in a high yield and w...  
WO/2020/179671A1
This invention provides: a curable resin composition including a specific polymer precursor, a nonionic compound B, and at least one compound selected from the group consisting of a polymerizable compound and a photosensitive compound, w...  
WO/2020/176825A1
This disclosure relates to methods of managing cancer using bis-biguanide compounds, such as alexidine, and pharmaceutical compositions comprising the same. In certain embodiments, this disclosure relates to methods of treating lung canc...  
WO/2020/084599A3
The present invention relates to ammonium salts of partially fluorinated organic acids, represented by the general formula 1. The present invention relates also to a synthesis method of said salts as well as its use to the production of ...  
WO/2020/139300A2
The present invention relates to a pharmaceutical combination comprising granulocyte-colony stimulating factor (G-CSF) and a biguanide compound for treating a patient with cancer with a targeted therapy in combination with chemotherapies.  
WO/2020/049365A3
The use of PREVORA brand topical dental solution (100 mg/ml chlorhexidine) sold by CHX Technologies, Inc., Toronto, Canada, to treat and/or prevent the advance of both dental decay (caries) and periodontal disease, simultaneously and in ...  
WO/2020/120637A1
The application relates to a compound of formula (I) or a pharmaceutical salt thereof of formula (II), as well as to a process to obtain said compound and a process to obtain said salt. Additionally disclosed is the compound of formula (...  
WO/2020/107500A1
The present invention provides a 2-(1-acyloxypentyl) benzoic acid salt formed by basic amino acid or aminoguanidine, a preparation method thereof, a pharmaceutical preparation containing the salt and the uses of the pharmaceutical prepar...  
WO/2020/084599A2
The present invention relates to ammonium salts of partially fluorinated organic acids, represented by the general formula 1. The present invention relates also to a synthesis method of said salts as well as its use to the production of ...  
WO/2019/109067A3
The present disclosure provides creatine prodrug analogs and their compositions useful for the treatment of creatine deficiencies.  
WO/2020/061477A1
Disclosed are methods of treating creatine transporter deficiency, comprising administering to a mammal in need thereof a therapeutically effective amount of a compound that increases transport of a substrate by a mutant or wild-type cre...  
WO/2020/060451A1
The invention concerns a method for making ammonium dinitramide from guanylurea dinitramide in one single process step. Guanylurea dinitramide is reacted with an ammonium sulfate in a reaction solution comprising water and optionally ace...  
WO/2020/061367A1
The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions fu...  
WO/2020/022783A9
The present invention pertains to: a novel p62 ligand compound or a stereoisomer, solvate, hydrate, or prodrug thereof; and a pharmaceutical or food composition containing same as an active ingredient for preventing or treating protein a...  
WO/2020/045326A1
The present invention provides a benzoic ester compound having an enteropeptidase inhibitory activity and a use of the compound as a medicine for the treatment or prevention of obesity, diabetes, etc. The compound is represented by formu...  
WO/2020/022783A1
The present invention pertains to: a novel p62 ligand compound or a stereoisomer, solvate, hydrate, or prodrug thereof; and a pharmaceutical or food composition containing same as an active ingredient for preventing or treating protein a...  
WO/2020/022784A1
The present invention relates to a novel p62 ligand compound, or a stereoisomer, solvate, hydrate, or prodrug thereof, and a pharmaceutical or food composition for preventing or treating proteopathies comprising same as an active ingredi...  
WO/2019/233982A1
The present invention relates to new compounds of formula (I), and their uses.  
WO/2019/232403A1
Described herein are compositions and methods for treating a disease or disorder associated with PI3K signaling. For example, such compositions can include use of modulators of glucose metabolism, use of at least one kinase in the insuli...  
WO/2019/216322A1
Provided is a curable composition that contains an epoxy compound having two or more epoxy groups in each molecule thereof and a compound represented by general formula (1). In the formula, X is a group represented by general formula (1)...  
WO/2019/199731A1
The present invention relates to crystalline forms of amphetamine-homoarginine conjugate 1- homoarginine-d-amphetamine, which is an amphetamine prodrug useful in the treatment of various diseases and conditions, and symptoms associated t...  
WO/2019/170705A1
This invention relates to a compound according to general formula (IA), which acts as a selective cysteine protease inhibitor; to a pharmaceutical composition containing one or more of the compound(s) of the invention; to a combination p...  
WO/2019/154769A1
The present invention relates to an improved process for the preparation of metformin hydrochloride, an important drug in the first line treatment of Type II Diabetes.  
WO/2019/150323A1
Ionic liquids of creatine comprising a creatine anion and a cation., as well as their means of manufacture. Examples of the ionic liquids of creatine are choline creatinate, betaine ethyl ester creatinate and agmatine creatinate are desc...  
WO/2019/100261A1
A metformin hydrochloride synthesis system and a preparation method therefor, the synthesis system comprising a reaction apparatus (20), the reaction apparatus (20) being provided with a feed opening and a reactant discharge opening, and...  
WO/2019/088270A1
The present invention provides a compound that is highly safe and that is useful in the prevention, alleviation, and/or treatment of various diseases involving enteropeptidase inhibition and/or trypsin inhibition, a pharmaceutical compos...  
WO/2019/084451A1
Food compositions or dietary supplements comprising an effective amount of an additive that comprises at least one oral hypoglycemic agent for the treatment, prevention, control and management of blood sugar and insulin spikes associated...  
WO/2019/079707A1
The disclosure generally relates to the detection of symmetrical dimethylarginine (SDMA). More particularly, the disclosure relates to the detection of SDMA using a solid phase. The disclosure provides devices, reagents, kits and methods...  
WO/2019/071353A1
A method of reducing glutamate efflux from skeletal muscle by inhibiting system Xc- activity is provided. The method is useful for the treatment of statin-induced myalgia. Pharmaceutical compositions useful to treat statin-induced myalgi...  
WO/2019/062661A1
The present invention relates to the field of pharmaceutical chemistry, and specifically, to a kind of oseltamivir derivatives that are neuraminidase inhibitors containing carbamido, a preparation method therefor, and medical uses thereo...  
WO/2019/055280A1
The invention provides diethanolamine and morpholine salts of ursolic acid. Compositions containing the salts, and methods of using the salts are also provided.  
WO/2019/047866A1
Disclosed are novel compounds, pharmaceutical compositions and methods of preparation and use thereof for treating disease affecting the central nervous system such as multiple sclerosis.  
WO/2019/008027A1
The present disclosure relates to compounds of formula (I) or a pharmaceutically acceptable salt thereof wherein R1 means a fluorine atom or a perhalogeno linear alkyl radical containing 1, 2 or 3 carbon atoms; R2 means a chlorine atom, ...  
WO/2018/233326A1
A hydrogen sulfide donor in an organic salt form and a preparation method therefor. The hydrogen sulfide donor is a salt structure formed by organic compounds with an alkaline structure and hydrogen sulfide. The hydrogen sulfide donor ha...  
WO/2018/226368A1
A method for removing carbon dioxide from a gaseous source, the method comprising: (i) contacting said gaseous source with an aqueous solution of a carbon dioxide sorbent that reacts with carbon dioxide to form an aqueous-soluble carbona...  
WO/2018/216926A1
Provided is a composition containing an alkyl lactate, an anti-hydrolysis agent, and water, wherein the anti-hydrolysis agent is a basic amino acid.  
WO/2018/210633A1
The present invention relates to a method for the production of phenylguanidines or the salts thereof by reacting an aniline that has electronegative substituents with a cyanamide-containing mixture.  
WO/2018/208647A1
Provided are embodiments of creatine and creatine ethyl ester (CEE) salts where the anion is an artificial (non-saccharide) taste-modifier. These compounds represent stable white non-hygroscopic solids or semisolids that can readily diss...  
WO/2018/172168A1
The present invention relates to a guanidine of the formula (I) and to the use thereof as catalyst for the crosslinking of a functional compound, especially a polymer having silane groups. The guanidine of the formula (I) described is pr...  
WO/2018/170306A1
The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions fu...  
WO/2018/159650A1
The purpose of the present invention is to provide a compound which has a guanidine skeleton and inhibits the protease activity of MALT1 to exhibit a therapeutic effect or prophylactic effect on autoimmune diseases such as psoriasis. The...  
WO/2018/135977A1
The invention relates to the field of pharmaceutical chemistry, namely to new biologically active substances and their use and to a method of production. In particular, the invention relates to a derivative of creatine - phenylcreatine, ...  
WO/2018/132827A1
Disclosed is nucleic acid preserving compositions and methods of manufacturing and using the same. Compositions include a carrier, a chaotropic agent, a buffering agent, a chelating agent, a surfactant, an alcohol, an acid, and a mucolyt...  
WO/2018/106938A1
The present disclosure is directed to polymeric coatings. The coatings can include a substrate-coordinating functionality as well as additional functionality for interacting with the surrounding environment. For example, the coatings can...  
WO/2018/106907A1
The present invention provides novel fused bicyclic alkylene linked imidodicarbonimidic diamides. In particular, described herein are N-[2-(indol-3- yl)alkylene]-linked imidodicarbonimidic diamides and N-[2-(pyrrolopyridin-3- yl)alkylene...  
WO/2018/097172A1
The present invention provides: compounds represented by formula (IV) (in the formula, Ar represents a substituted or unsubstituted phenylene group; X and Z each independently represent a substituted or unsubstituted alkylene group, etc....  
WO/2018/096504A1
Compounds of Formula (I), including stereoisomers and salts thereof, and compositions, methods of treatment and prevention, and methods of preparing, the same: Formula (I) wherein X is O or a direct bond; wherein when X is O, R1 and R2 a...  
WO/2018/097126A1
Compounds represented by formula (I) or salts thereof. A fungicide or plant disease control agent containing as an active ingredient at least one selected from the group consisting of said compounds and salts thereof. In formula (I), Ar ...  
WO/2018/087753A1
The present invention provides cationic lipids and lipid nanoparticle formulations comprising these lipids, alone or in combination with other lipids. These lipid nanoparticles may be formulated with nucleic acids to facilitate their int...  

Matches 1 - 50 out of 3,385