Title:
S-(+)-FLURBIPROFEN SALT, METHOD FOR PREPARING SAME, PHARMACEUTICAL COMPOSITION THEREOF, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/060373
Kind Code:
A1
Abstract:
Provided are a (+)-flurbiprofen salt derivative, a compound represented by the following formula (I), a method for preparing same, a pharmaceutical composition thereof, and use thereof.
Inventors:
SHI JIANGTAO (CN)
FU HAIJIAN (CN)
FU HAIJIAN (CN)
Application Number:
PCT/CN2022/131059
Publication Date:
March 28, 2024
Filing Date:
November 10, 2022
Export Citation:
Assignee:
NANJING ZHIHE MEDICINE TECH CO LTD (CN)
International Classes:
A61K31/192; A61P19/02; A61P19/08; A61P29/00; C07B57/00; C07C57/58; C07C229/26; C07C279/14; C07D233/64
Foreign References:
| CN115536525A | 2022-12-30 | |||
| CN1130354A | 1996-09-04 | |||
| CN1207677A | 1999-02-10 | |||
| CN111840215A | 2020-10-30 | |||
| CN111846514A | 2020-10-30 |
Other References:
ÖZTÜRK A ALPER, İLGE ÇINAR NUR, YENILMEZ EVRIM: "Development of nano-sized ketoprofen lysine incorporated Eudragit ® S100 nanomedicine by double emulsion solvent evaporation and in vitro characterization", JOURNAL OF PHARMACY & PHARMACOGNOSY RESEARCH, vol. 7, no. 1, 15 December 2018 (2018-12-15), pages 47 - 58, XP093150022, ISSN: 0719-4250
TSUNEMATSU H., ET AL.: "SYNTHESIS AND THE STEREOSELECTIVE ENZYMATIC HYDROLYSIS OF FLURBIPROFEN-BASIC AMINO ACID ETHYL ESTERS.", JOURNAL OF DRUG TARGETING, TAYLOR & FRANCIS, GB, vol. 02., no. 06., 1 January 1995 (1995-01-01), GB , pages 517 - 525., XP000923073, ISSN: 1061-186X
TSUNEMATSU H., ET AL.: "SYNTHESIS AND THE STEREOSELECTIVE ENZYMATIC HYDROLYSIS OF FLURBIPROFEN-BASIC AMINO ACID ETHYL ESTERS.", JOURNAL OF DRUG TARGETING, TAYLOR & FRANCIS, GB, vol. 02., no. 06., 1 January 1995 (1995-01-01), GB , pages 517 - 525., XP000923073, ISSN: 1061-186X
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