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WO/1996/019430A1 |
An improved process is disclosed for purifying impure aromatic polycarboxylic acids produced by the catalytic oxidation of polyalkylaromatic hydrocarbons which comprises contacting said impure acid with hydrogen and at least one hydrogen...
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WO/1996/019432A1 |
Disclosed is a process for the purification of aromatic dicarboxylic acids in which the salt of an aliphatic diamine and an aromatic dicarboxylic acid is formed in an aqueous solvent, recrystallized, and contacted with an aliphatic dicar...
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WO/1996/015099A1 |
The present invention relates to therapeutically active heterocyclic compounds of formula (I) wherein n is 0, 1 or 2; and X is -O-, -S, -N(R5)- or -CH2-; and R1 is H, NH2, NHR5 or OH; and R2 and R3 independently are H, COOH, COOR5, CONH2...
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WO/1996/015096A1 |
Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, and a process for using them to treat a variety of physiological conditions. The compounds of the invention have the generalized formula (T)xA-B-D-E-G, ...
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WO/1996/015100A1 |
The present invention relates to therapeutically active heterocyclic compounds of formula (I), wherein n is 0, 1 or 2; and X is -O-, -S, -N(R5)- or -CH2-; and R1 is H, NH2, NHR5 or OH; and R2 and R3 independently are H, COOH; COOR5, CONH...
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WO/1996/011925A1 |
This invention relates to novel benzopyran and other benzo-fused leukotriene B4 (LTB4) antagonists of formula (I), and the pharmaceutically acceptable salts thereof wherein A1 is O, CH2, S, NH or N(C1-C6)alkyl; A2 is (a), (b) or (c); R1 ...
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WO/1996/011899A1 |
A process for preparing aromatic carboxylic acids by the exothermic liquid-phase oxidation reaction of an aromatic feedstock compound, wherein energy is efficiently recovered from the exothermic oxidation reaction, particularly by the us...
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WO/1996/006065A1 |
In a process for production of an aromatic dicarboxylic acid such as terephthalic acid by the liquid phase oxidation of a precursor (e.g. p-xylene) thereof, an overheads stream (10) comprising aqueous aliphatic carboxylic acid is subject...
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WO/1996/005165A1 |
Compounds of formula (I) wherein R1-R7, R10, X and the dotted bond have the meaning given in the specification, bind selectively to retinoid RXR receptors and are useful as antiproliferative agents for dermatological and oncological indi...
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WO/1996/003356A1 |
A method of iodinating and/or brominating and/or chlorinating an aromatic compound which comprises the steps of reacting an iodinating agent and/or brominating agent and/or chlorinating agent with the aromatic compound in the presence of...
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WO/1996/002486A1 |
The present invention relates to novel 4-halo-2-fluoro-5-alkylbenzoyl compounds and their methods of manufacture. These compounds are useful for the preparation of agricultural chemicals and medicines, particularly as intermediates for a...
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WO/1996/002515A1 |
The disclosure herein relates to the title compounds of formula (I) and salts and esters thereof, wherein X is halogen, C1-6 polyhaloalkyl, C6-10 aryloxy, C1-6 alkoxy or alkylsulfonyl, C4-10 tert-alkyl, NO2 or CN; n is 0-4 and Z is an (u...
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WO/1996/000088A1 |
A radiographic imaging agent including a plurality of block copolymers forming a micelle, the block copolymers including a hydrophilic polymer linked to a hydrophobic polymer, and the hydrophobic polymer including a backbone incorporatin...
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WO/1995/034300A1 |
Process for the preparation of (-)-pimara-9(11), 15-diene-19-oic acid(acanthoic acid) and pharmaceutical compositions comprising acanthoic acid useful for the treatment of diseases caused by an excessive production of interleukin-1 or tu...
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WO/1995/033702A1 |
The pH and moisture values of the proposed water-soluble humic acids, which have mean molecular weights of 5000-100,000, are given by the formula W 100 - 25 (pH - 2), where 2 < pH 6. A method is proposed for obtaining water-soluble humic...
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WO/1995/029952A1 |
A process for recycling polyester contained in waste materials is provided. The polyester is converted into a corresponding acid salt of a polybasic organic acid and a polyol. The process steps generally include first combining materials...
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WO/1995/029886A1 |
The present invention concerns processes for preparing aromatic, bromine-containing compounds, novel bromine-containing compounds and their use as intermediate products in the synthesis of active agents. Processes according to the invent...
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WO/1995/029171A1 |
A method for making arthropodicidal oxadiazines and intermediates which are racemic or enantiomerically enriched at their chiral center, the method for making the oxadiazines comprising reaction of an intermediate selected from (II) or (...
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WO/1995/024897A1 |
2-Chloro-5-nitrobenzoic acid and various other chloro and nitro substitute benzoic acid derivatives are disclosed for administration in tablet or injectable solution form for the prophylaxis and therapy of neoplasm or viral infection. Th...
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WO/1995/024373A1 |
A process for the monodecarboxylation of a halogenated aromatic dicarboxylic acid or derivative thereof in which the halogenated aromatic dicarboxylic acid or derivative thereof in a liquid medium is heated characterised in that the liqu...
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WO/1995/023126A1 |
The invention relates to a process for the preparation of cinnamic acid derivatives which involves reacting chlorinated aromatic compounds and acrylic acid derivatives in the presence of palladium catalysts.
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WO/1995/022520A1 |
A compound of structure (I), wherein, when R8 = H: R1 = alkyl, cycloalkyl, arylalkyl, aryl; R2 = cycloalkyl, aryl, C3-C10 alkyl; X, Y = O, S(O)n, NH; Z = CH2OH, NHSO2R3, CHO, CO2R3, CONHR4R5, CN, COR6, H, halo, NHCN, NHCONR4R5, CONR4OR5,...
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WO/1995/015752A1 |
This invention relates to a compound of formula (I), where the several groups are defined herein. These compounds are leukotriene antagonists and as such can be used in treating various diseases associated with leukotrienes.
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WO/1995/014688A1 |
The application relates to derivatives of 2,3,5,6-tetrafluorobenzoic acid of formula (I) wherein Y represents oxygen or sulphur and X represents the groups -O- N=CR1R2, -OR3, -OCHR4-CO-NR5R6 or -NR7R8 as well as a process for manufacturi...
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WO/1995/011242A1 |
Compounds of formula (I), wherein m is 1-4; R1-R4 independently are hydrogen, lower alkyl of 1 to 6 carbons, Cl, Br, or I; R5 is hydrogen, lower alkyl of 1 to 6 carbons, Cl, Br, I, lower alkoxy or lower thioalkoxy of 1-6 carbons; R6 is h...
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WO/1995/010499A1 |
Technology for recycling polymers, such as polyethylene terephthalate (PET), is increasingly important in reducing the amount of polymeric materials deposited in landfills. The invention employs a base hydrolysis process to depolymerize,...
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WO/1995/009143A1 |
Disclosed herein is a process for producing highly purified benzenedicarboxylic acid isomers without an additional catalytic reductive purification step, which comprises (a) an oxidation step wherein xylene isomer is oxidized with molecu...
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WO/1995/004036A1 |
Compounds, compositions, and methods for modulating processes mediated by Retinoid X Receptors using retinoid-like compounds which have activity selective for members of the subclass of Retinoid X Receptors (RXRs), in preference to membe...
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WO/1994/027584A2 |
Various arylating agents having activity in the treatment of cancer and viral infection are disclosed. The active compounds include an aromatic ring having at least one labile leaving group and at least one electrophilic group. Preferred...
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WO/1994/020447A1 |
A method is disclosed for the purification of crude terephthalic acid, crude isophthalic acid or a crude naphthalene dicarboxylic acid that employs a titanium dioxide-supported purification catalyst.
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WO/1994/019082A1 |
A slurry containing crystals in an impurity-containing mother liquor under elevated pressure and temperature conditions is processed to separate the crystals from the mother liquor. The processing comprises highly efficient separation an...
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WO/1994/015901A1 |
Compounds, compositions, and methods for modulating processes mediated by Retinoid X Receptors using retinoid-like compounds which have activity selective for members of the subclass of Retinoid X Receptors (RXRs), in preference to membe...
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WO/1994/015902A1 |
Compounds, compositions, and methods for modulating processes mediated by Retinoid X Receptors using retinoid-like compounds which have activity selective for members of the subclass of Retinoid X Receptors (RXRs), in preference to membe...
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WO/1994/013666A1 |
The invention provides an industrially excellent process for producing a 2-alkyl-3-(biphenyl-4-yl)-methyl-3H-imidazo[4.5-b]pyridine derivative represented by general formula (II), serving as a precursor of the angiotensin II receptor ant...
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WO/1994/012880A2 |
The invention provides a method of screening a substance for the ability to affect the formation of a retinoid X receptor homodimer comprising combining the substance and a solution containing retinoid X receptors and determining the pre...
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WO/1994/010121A1 |
Ester bonds are hydrolyzed in the conversion of substantially amorphous polyesters to their monomeric components, by being contacted with a mixture of (a) an alcohol, such as methanol, or glycol, (b) a polar aprotic solvent such as N-met...
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WO/1994/004481A1 |
Provided is a process for preparing 2,5-diphenylterephthalic acid, which is useful in preparing certain polyesters, especially liquid-crystalline polyesters. In this process, p-xylene is di-alkylated with cyclohexene to provide 2,5-dicyc...
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WO/1994/004502A1 |
A process for the preparation of halobenzoic acids, comprising the step of reacting a halonitrobenzene with a pyridinium salt to form an intermediate of formula (I), wherein R is selected from the group consisting of hydrogen, alkyl, ary...
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WO/1994/004480A1 |
Provided is a facile three step process for preparing 2-phenylterephthalic acid starting with p-xylene, followed by alkylation, dehydrogenation, and oxidation of the methyl groups corresponding to the original p-xylene. The product, 2-ph...
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WO/1994/001388A1 |
Novel difunctionalized cyclobutabenzene monomers of general formula (I), wherein Z can be hydrogens or a cyclobutane ring; and X and Y are carboxyl, amino, alcohol, isocyanate, acid halide, or bis-acyl fluoride groups. Methods of making ...
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WO/1994/000413A1 |
Disclosed is a method for preparing an aromatic carboxylic acid comprising oxidizing in the liquid phase an aromatic feed compound containing at least one alkyl or acyl group with a molecular oxygen-containing gas, in a solvent comprisin...
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WO/1993/025223A1 |
The invention provides a method of screening a substance for the ability to affect the formation of a retinoid X receptor homodimer comprising combining the substance and a solution containing retinoid X receptors and determining the pre...
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WO/1993/025530A2 |
A process and pharmaceutical compositions for treating several diseases and conditions which are normally treatable with retinoid-like compounds are disclosed where the compounds used for the treatment are substantially non-teratogenic a...
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WO/1993/024440A1 |
A process for the production of purified terephthalic acid comprises subjecting an aqueous solution of crude terephthalic acid to hydrogenation to reduce impurities therein, crystallising the resulting solution to produce a slurry of pur...
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WO/1993/024441A1 |
A process for the production of purified terephthalic acid (PTA) from crude terephthalic acid (CTA) comprising mixing the CTA with an aqueous medium to form an aqueous CTA mixture, heating the mixture to dissolve substantially all of the...
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WO/1993/024442A1 |
A medicine containing a benzoic acid derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof, and any of novel benzoic acid derivatives represented by general formulae (II), (III) and (IV), all include...
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WO/1993/023359A1 |
In plant for the production and processing of an aromatic carboxylic acid such as terephthalic acid, at least some of the plant components (especially those exposed to an acidic reaction medium at elevated temperatures and pressures in e...
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WO/1993/021146A1 |
Compounds, compositions, and method for modulating processes mediated by Retinoid X Receptors using retinoid-like compounds which have activity selective for members of the subclass of Retinoid X Receptors (RXRs), in preference to member...
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WO/1993/015067A1 |
Benzopyran and other benzo-fused leukotriene B4 antagonists have formula (I) wherein R1 is a phenyl or substituted phenyl group, and A, n, R2 and R3 are as defined herein.
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WO/1993/012065A1 |
A process for preparing purified 2,6-naphthalenedicarboxylic acid comprises hydrolyzing a dialkyl-2,6-naphthalenedicarboxylate with water at a reaction temperature of at least about 450 °F under liquid phase condition, the amount of wat...
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