Heterocyclic Compounds

Matches 1,451 - 1,500 out of 5,694	< 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 >

Document	Document Title
WO/2007/050732A1	INDAZOLE DERIVATIVES THAT INHIBIT TRPVl RECEPTOR Compounds of formula (I), wherein A, R1, R2, and R3 are defined in the specification, and which are useful as therapeutic compounds particularly for treating disorders or conditions associated with inflammation, pain, bladder overactivit...
WO/2007/046747A1	NOVEL BICYCLIC SULFONAMIDES FOR USE AS GLUCOCORTICOID RECEPTOR MODULATORS IN THE TREATMENT OF INFLAMMATORY DISEASES Compounds of formula (I): or a pharmaceutically acceptable salt thereof; compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating the glucocorticoid receptor in a warm blooded an...
WO/2007/042321A2	KINASE INHIBITORS The present invention relates to new AGC kinase inhibitors, in particular to compounds of Formula I, II, or III or a stereoisomer, tautomer, racemic, metabolite, pro- or predrug, salt, hydrate, or solvate thereof, I II III wherein X, R1,...
WO/2007/041969A1	GLYCYRRHETINIC ACID-30-AMIDE DERIVATIVES AND THE USES THEREOF The present application belongs to pharmaceutical field of inflammation, immunity and infection. The present application has disclosed glycyrrhetinic acid-30-acidamide derivatives and their preparation methods, as well as pharmaceutical ...
WO/2007/043621A1	TOTAL SYNTHESIS OF PLADIENOLIDE B AND PLADIENOLIDE D Disclosed is a process for production of a compound represented by the formula (11): (11) [wherein P1 represents a hydrogen atom or a protective group for a hydroxyl group; P7 represents a hydrogen atom or a protective group for a hydrox...
WO/2007/044729A2	N- (3-AMINO-QUINOXALIN-2-YL) -SULFONAMIDE DERIVATIVES AND THEIR USE AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS The present invention comprises small molecule inhibitors of phosphatidylinositol 3-kinase (PI3K), which is associated with a number of malignancies such as ovarian cancer, cervical cancer, breast cancer, colon cancer, rectal cancer, and...
WO/2007/039782A1	TETRAZOLE DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS The present invention relates to new compounds of formula (I) wherein Y1 and Y2 selected from the group consisting of hydrogen, halogen atom, C1-4 alkyl, C1-4 alkoxy or cyano group, X is oxygen or two hydrogen atoms; Z is -(CH2)n- group ...
WO/2007/039609A1	PYRANODIBENZOFURAN DERIVATIVES WITH ANTIFUNGAL AND ANTIBACTERIAL ACTIVITY Compound of the general formula (I): and in particular compounds of formula (II), (III), (IV), their process of preparation and their use as medicament for the treatment of fungal or bacterial infections, in particular mycobacterial infe...
WO/2007/025899A1	DIAMINOPYRIMIDINES AS P2X3 AND P2X2/3 MODULATORS Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I), wherein D, X, R1, R2,...
WO/2007/022845A1	NOVEL MATERIALS FOR ORGANIC ELECTROLUMINESCENT DEVICES The invention relates to compounds of formula (1) and to the use thereof in organic electroluminescent devices. The compounds of formula (1) are used as host material or as a dopant in the emitting layer and/or as hole transport material...
WO/2007/022380A2	BIS-ARYL AMIDE COMPOUNDS AND METHODS OF USE The present invention comprises a new class of compounds useful for the prophylaxis and treatment of protein kinase mediated diseases, including autoimmune disease and inflammation. In one embodiment, the compounds have a general Formula...
WO/2007/022258A1	NOVEL HIGH AFFINITY THIOPHENE-BASED AND FURAN-BASED KINASE LIGANDS Inhibitors of cyclin dependent kinase 2, compositions including the inhibitors, and methods of using the inhibitors and inhibitor compositions are described. The inhibitors and compositions including them are useful for treating disease ...
WO/2007/021794A1	SUBSTITUTED IMIDAZOLE COMPOUNDS AS KSP INHIBITORS The present invention relates to new substituted imidazole compounds and pharmaceutically acceptable salts, esters or prodrugs thereof, compositions of the derivatives together with pharmaceutically acceptable carriers, and uses of the c...
WO/2007/018954A2	APPLICATION OF A BIOACTIVE AGENT IN A SOLVENT COMPOSITION TO PRODUCE A TARGET PARTICLE MORPHOLOGY A selected morphology for a deposited bioactive agent can be obtained by selecting solvent composition (202), preparing a solution of the bioactive agent in the solvent composition (204), and applying the bioactive agent to a substrate a...
WO/2007/018887A2	APPLICATION OF A BIOACTIVE AGENT TO A SUBSTRATE A selected morphology for a deposited bioactive agent may be obtained by selecting a target particle morphology (102), preparing a solution of the bioactive agent (104), and applying the bioactive agent solution to a substrate as a plura...
WO/2007/018193A1	NOVEL CERCOSPORAMIDE DERIVATIVE The invention relates to a novel cercosporamide derivative which has a good hypoglycemic effect and is useful for a therapeutic drug and/or preventive drug for diabetes, a pharmacologically acceptable salt thereof or an ester thereof. [M...
WO/2007/018953A1	PREPARATION OF NANOPARTICLES Nanoparticles of a deposited bioactive agent can be obtained by selecting a solvent composition (102), preparing a solution of the bioactive agent (104), and applying the solution to a substrate as a plurality of droplets, such that evap...
WO/2007/013830A1	NITROCATECHOL DERIVATIVES AS COMT INHIBITORS New compounds of formula I are described. The compounds have potentially valuable pharmaceutical properties in the treatment of some central and peripheral nervous system disorders.
WO/2007/009662A1	SUBSTITUTED PIPERIDINE DERIVATIVES AS SOMATOSTATIN SST1 RECEPTOR ANTAGONISTS Compound of the formula (I) wherein R1, R2, n and m are as defined in the specification. The compounds of formula (I) are somatostatin sst1 receptor antagonists.
WO/2007/009201A2	PROCESS TO OBTAIN SYNTHETIC AND SEMI-SYNTHETIC LIGNAN DERIVATIVES, THEIR ANTIPARASITIC ACTIVITIES AND CORRESPONDING PHARMACEUTICAL FORMULATIONS, INCLUDING THE THERAPEUTIC METHOD USING SAID LIGNAN FOR THE TREATMENT OF PARASITOSIS The invention refers to a process to obtain synthetic and semi-synthetic derivatives of lignans, especially dibenzylbutyrolactonic, tetrahydrofuranic, aryltetralynic, furofuranic and dibenzocyclooctanic lignans obtained by means of parti...
WO/2007/010383A1	NOVEL HETEROCYCLIDENE ACETAMIDE DERIVATIVE Disclosed are a compound represented by the formula (I') below, a salt thereof, and a solvate of any of them. Also disclosed are a pharmaceutical composition containing such a compound as an active ingredient, and a TRPV 1 (Transient Rec...
WO/2007/011629A2	SYNTHESIS AND COMPLETE STEREOCHEMICAL ASSIGNMENT OF PSYMBERIN/IRCINIASTATIN FOR ANTI-TUMOR USE The invention relates to the synthesis and complete stereochemical assignments of cytotoxic compounds such as compound 28-a and its stereoisomers. The invention further provides processes for making the compounds, their synthetic interme...
WO/2007/006546A1	AMIDE DERIVATIVES AS KINASE INHIBITORS The present invention relates to new AGC kinase inhibitors, in particular to compounds of Formula (I) or (II) or a stereoisomer, tautomer, racemic, metabolite, pro- or predrug, salt, hydrate, or solvate thereof, wherein Ar1, Ar2, R1, R3,...
WO/2007/006547A1	AMIDE DERIVATIVES AS KINASE INHIBITORS The present invention relates to new AGC kinase inhibitors, in particular to compounds of Formula (I) or (II) or a stereoisomer, tautomer, racemic, metabolite, pro- or predrug, salt, hydrate, or solvate thereof, wherein Ar1, Ar2, R1, R3,...
WO/2007/003964A1	G-PROTEIN COUPLED RECEPTOR AGONISTS Compounds of formula (I): or pharmaceutically acceptable salts thereof, are GPCR agonists and are useful as for the treatment of obesity and diabetes.
WO/2007/004959A1	NEW COMPOUNDS, PROCESS FOR THEIR PREPARATION, INTERMEDIATES, PHARMACEUTICAL COMPOSITIONS AND THEIR USE IN THE TREATMENT OF 5-HT6 MEDIATED DISORDERS SUCH AS ALZHEIMER'S DISEASE, COGNITIVE DISORDERS, COGNITIVE IMPAIRMENT ASSOCIATED WITH SCHIZOPHRENIA, OBESITY AND PARKINSON'S DISEASE The present invention relates to new compounds of formula (I), or salts, solvates or solvated salts thereof, process for their preparation and to new intermediates used in the preparation thereof, pharmaceutical compositions containing s...
WO/2006/136924A1	HISTAMINE-3 RECEPTOR ANTAGONISTS This invention is directed to a compound of the formula Ia or Ib. as defined herein, or a pharmaceutically acceptable salt thereof; a pharmaceutical composition containing a compound of formula I, a method of treatment of a disorder or c...
WO/2006/136462A1	BENZOFURANONE DERIVATIVES AS NONSTEROIDAL PROGESTERONE RECEPTOR MODULATORS This invention relates to nonsteroidal progesterone receptor modulators of general formula (I), a process for their production, the use of progesterone receptor modulators for the production of pharmaceutical agents as well as pharmaceut...
WO/2006/133926A1	PYRAZOLE DERIVATES AS CANNABINOID RECEPTOR MODULATORS Compounds of formula (I), are cannabinoid CB1 receptors, useful, inter alia in the treatment of obesity: (I) wherein A1 is hydrogen, -COOH, or tetrazolyl, and A2 is hydrogen, -COOH, tetrazolyl, -CN, -CF3, -COR6, -SO2R6, -OR7, -NR7R8, -NH...
WO/2006/134163A2	NOVEL TETRACYCLIC TETRAHYDROFURAN DERIVATIVES CONTAINING A CYCLIC AMINE SIDE CHAIN This invention concerns novel substituted tetracyclic tetrahydrofuran derivatives containing a cyclic amine side chain with binding affinities towards dopamine receptors, in particular dopamine D2 receptors, towards serotonin receptors, ...
WO/2006/134955A1	1, 2-DI(CYCLIC GROUP)SUBSTITUTED BENZENE DERIVATIVE A compound represented by the general formula (1) or (100), a salt thereof or a hydrate of the compound or salt, which is excellent in cell adhesion-inhibitory effect and cell infiltration-inhibitory effect: (1) (100) wherein R10 represe...
WO/2006/131304A2	PROCESS FOR PREPARING RENIN INHIBITORS The invention related to a novel process, novel process Steps and novel intermediates useful in the synthesis of pharmaceutically active Compounds, especially renin inhibitors, such as Aliskiren. Inter alia, the invention relates to a pr...
WO/2006/131398A2	INHIBITORS OF SOLUBLE ADENYLATE CYCLASE The invention relates to compounds of general Formula (I), the production thereof, and the use thereof as a medicinal product.
WO/2006/131192A1	NEW MATERIALS FOR ORGANIC ELECTROLUMINESCENCE DEVICES The present invention relates to new materials which can be used in organic electronic devices, in particular electroluminescence devices, and which are specific derivates of condensed aromatic systems.
WO/2006/133326A1	INHIBITORS OF HCV REPLICATION Compounds having the structure of formula I are described. The compounds can inhibit hepatitis C virus (HCV) replication, and in particular can inhibit the function of the HCV NS5A protein.
WO/2006/128803A1	PIPERIDIN-4-YL-AMIDE DERIVATIVES AND THEIR USE AS SST RECEPTOR SUBTYPE 5 ANTAGONISTS This invention is concerned with compounds of the formula (1) wherein R1 to R5, R5' and A are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The invention further relates to pharmaceutical compos...
WO/2006/126939A1	NOVEL 8-SULFONYLAMINO-3 AMINOSUBSTITUTED CHROMAN OR TETRAHYDRONAPHTALENE DERIVATIVES MODULATING THE 5HT6 RECEPTOR The present invention relates to new compounds of formula I. (I) wherein R1 to R12, P, X, Q and n are as defined as in formula I, or salts, solvates or solvated salts thereof, processes for their preparation and to new intermediates used...
WO/2006/125511A1	PYRAN/DIOXAN DERIVATIVES AND USE THEREOF IN LIQUID CRYSTAL MEDIA The invention relates to pyran/dioxan derivatives and use thereof as components in liquid crystal media. The invention further relates to liquid crystal and electrooptical display elements, comprising said liquid crystal media.
WO/2006/125529A1	FORMYLTETRAHYDROPYRANS, METHOD FOR THE PRODUCTION THEREOF AND USE THEREOF IN THE PRODUCTION OF LIQUID CRYSTAL COMPOUNDS The invention relates to formyltetrahydropyrans comprising mesogenic substituents, to a method for the production thereof and to the use thereof for producing substituted tetrahydropyran derivatives.
WO/2006/125530A1	TETRAHYDROPYRANE DERIVATIVES COMPRISING SEVERAL RINGS CONTAINING OXYGEN AND METHOD FOR THE PRODUCTION THEREOF The invention relates to a method for producing tetrahydropyrane derivatives which comprise at least one additional ring containing oxygen. The invention also relates to, in particular, compounds having two tetrahydropyrane rings or at l...
WO/2006/121922A1	MONOAMINE RE-UPTAKE INHIBITORS AND METHODS RELATING THERETO Monoamine re-uptake inhibitors and more specifically serotonin and noradrenaline re-uptake inhibitors are disclosed that have utility in the treatment of disorders of the central or peripheral nervous system in both men and women. The co...
WO/2006/121218A1	N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS The present invention provides a pyrrolidine compound of General Formula (1) or a salt thereof, wherein R¿101? and R¿102? are each independently a phenyl group or a pyridyl group, the phenyl group or the pyridyl group may have one or m...
WO/2006/121097A1	BICYCLIC HETEROCYCLIC DERIVATIVE OR SALT THEREOF [PROBLEMS] To provide a compound which can be used as a therapeutic agent for a disease in which an EP1 receptor is involved, particularly a lower urinary tract disease such as pollakiuria/urinary urgency and incontinence associated with...
WO2006093823A9	2- [ ISOQUINOLIN-S - CARBONYL ) AMINO] -PROPIONIC ACID DERIVATIVES AS INHIBITORS OF FACTORS XI AND IX FOR THE TREATMENT OF THROMBOSIS This invention provides aryl and heteroaryl compounds of formula (X). The compounds of the invention may be useful as antagonists, or partial antagonist of factor IX and/or factor Xl and thus, may be used to inhibit the intrinsic pathway...
WO/2006/114371A1	NOVEL COMPOUNDS FOR TREATING INFLAMMATORY DISEASES The invention relates to novel compounds of formula (1), heteroderivatives thereof, and pharmacologically compatible salts, diastereomers, enantiomers, racemates, hydrates or solvates thereof, that are suitable for treating respiratory o...
WO/2006/116355A1	ORTHO-TERPHENYL INHIBITORS OF P38 KINASE AND METHODS OF TREATING INFLAMMATORY DISORDERS The present invention relates to compounds and methods useful as inhibitors of p38 kinase for the treatment or prevention and treatment of diseases such as inflammatory diseases, autoimmune diseases, destructive bone disorders, prolifera...
WO/2006/113981A2	PROCESS TO OBTAIN DIBENZYLBUTYROLACTONIC, TETRAHYDROFURANIC LIGNANS AND THEIR SYNTHETIC AND SEMI-SYNTHETIC DERIVATIVES, THEIR ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES, TOPICAL AND/OR SYSTEMIC FORMULATIONS CONTAINING SAID LIGNANS AND THEIR RESPECTIVE THERAPEUTIC METHOD The present invention refers to a process to obtain dibenzylbutyrolactonic lignans form (-)- cubebin, insolate from a Piperaceae, especially Piper cubeba, and from (-)-methylpluviatolide insolated form a Rutacea, especially Zanthoxylum n...
WO/2006/116150A1	DIHYDROBENZOFURAN DERIVATIVES AND USES THEREOF Compounds of formula (I) are described herein which are agonists or partial agonists of the 2C subtype of brain serotonin receptors. Formula (I), or pharmaceutically acceptable salts thereof, wherein each of R1, R2, R3, R4, Rx, Ry, and n...
WO/2006/111858A2	BIS-(COUMARIN) COMPOUNDS WITH ANTI-INFLAMMATORY ACTIVITY Certain bis-(coumarin) compounds of formula (VI) as well as the products of thei intramolecular cyclization including pharmaceutically acceptable salts, hydrates, solvates, clathrates, prodrugs, tautomers and stereoisomers thereof are di...
WO/2006/113458A1	HETEROCYCLIC INHIBITORS OF PROTEIN ARGININE METHYL TRANSFERASES A compound of formula I, or a stereoisomer, a tautomer, a pharmaceutically acceptable salt or solvate thereof, methods of using such compounds in the treatment of hyperproliferative, inflammatory, infectious, and immunoregulatory disorde...

Matches 1,451 - 1,500 out of 5,694	< 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 >