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WO/1996/023479A2 |
The invention concerns the use of a compound or a number of compounds from the group of the carbohydrates or carbohydrate derivatives as anti-adhesive active principles directed against micro-organisms, parasites and protozoa.
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WO/1996/019988A1 |
The present invention relates to novel 4,4-(disubstituted)cyclohexan-1-ols monomers and related compounds, pharmaceutical compositions containing these compounds, and their use in treating allergic and inflammatory diseases and for inhib...
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WO/1996/016973A1 |
A keratan sulfate oligosaccharide comprising a di- to penta-saccharide which has a sulfated N-acetylglucosamine at the reducing end and wherein at least two hydroxyl groups per molecule have been sulfated, preferably one containing a dis...
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WO/1996/009828A1 |
A novel class of highly sulfated maltooligosaccharides having heparin-like properties is described, as well as methods for using these oligosaccharides to treat certain diseases including cancer, retinopathies, and cardiovascular diseases.
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WO/1996/009310A1 |
The present invention relates to derivatives of phosphorylated carbohydrates and pharmaceutical compositions comprising as a pharmaceutically active ingredient at least one of these compounds.
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WO/1996/005843A1 |
A process for the preparation of sucralfate gel, in the dry state, that does not lose its colloidal properties is disclosed. Moreover, taking into consideration the particular tropism of sucralfate gel towards the gastric mucosa and its ...
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WO/1996/005209A2 |
Compounds that are synthetically inexpensive to make relative to the naturally occurring selectin ligands and that retain selectin binding activity are described that have a three-dimensionally stable configuration for sialic acid and fu...
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WO/1996/003413A2 |
Inter alia, a direct method for the regioselective sulfation of an organic molecule having optionally derivatized hydroxyl groups at least on two adjacent carbon atoms characterised in that it comprises the treatment of a di-(optionally ...
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WO/1995/034571A2 |
It has been found that sugar acid salts represent beneficial controlled release forms for basic organic drug compounds. Examples of appropriate salts include mono, di, oligo and polysaccharide poly-O-sulphonic acid salts of antibiotics s...
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WO/1995/021180A1 |
Compounds and methods of making them having formula (I) are described which bind to selectin receptors and thus modulate the course of inflammation, cancer and related diseases by modulating cell-cell adhesion events. In said formula eac...
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WO/1995/018787A1 |
A process and catalyst composition are provided for the highly efficient enantioselective hydrogenation of dehydroamino acid derivatives. The catalyst composition comprises rhodium or iridium and a diphosphinite carbohydrate ligand, wher...
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WO/1995/015969A1 |
The present invention consists in methods of preparing sugar derivatives either in isolation or from glycopeptides or glycoproteins. The methods comprise producing sugar hydrazones, sugar pyrazoles, glycosylpyrazones, azoglycan dyes and ...
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WO/1995/009637A1 |
A novel class of highly sulfated maltooligosaccharides having heparin-like activity is described, as well as methods for using these oligosaccharides to treat certain diseases including cancer, retinopathies, and cardiovascular diseases....
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WO/1995/007919A1 |
The internally cyclized congeners of hydroxy-substituted nucleotide analogues have been found to exhibit substantially lower toxicity in vivo than their uncyclized analogues, while retaining essentially the same antiviral activity. This ...
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WO/1995/007920A1 |
Nucleotide analogs characterized by the presence of an amidate linked amino acid or an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise a phosphoamidate or es...
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WO/1995/007914A1 |
The present invention relates to novel amino glycoside salts of sucrose-octa-O-sulfonic acid having the general formula (I): ([sucrose-octa-O-sulfonic acid8-]-[R-(NH3+)x]y-Mzn+), wherein (x . y) + (z . n) = 8, x . y N|[4 x . y 8], N is t...
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WO/1995/005389A1 |
The invention provides glycoconjugates which bind polynucleotides in a sequence-selective manner and/or preferentially displace or inhibit binding of transcription factors to their recognition sites on DNA. The DNA-binding glycoconjugate...
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WO/1994/026759A1 |
Selectin receptor binding is modulated by a method which utilizes heparin-like oligosaccharides. The figure shows a schematic drawing of the molecules involved in leukocyte adhesion to the vessel wall.
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WO/1994/022885A1 |
A series of sulfated disaccharides having blocked anomeric centers have been shown to exhibit blood anticoagulant properties specific to inhibition of factor IXa, and can be used in vivo to inhibit clotting, extracorporeally, or in vitro...
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WO/1994/022437A2 |
Therapeutic compounds and methods for inhibiting amyloid deposition in a subject, whatever its clinical setting, are described. Amyloid deposition is inhibited by the administration to a subject of an effective amount of a therapeutic co...
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WO/1994/020512A2 |
Disclosed are: (1) methods for identifying natural and synthetic sequences having binding specificity for glycan-binding proteins, including proteins that act as effectors of biological activity, (2) compositions and methods of producing...
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WO/1994/019360A1 |
The invention relates to methods that permit the rapid construction of oligosaccharides and other glycoconjugates. Methods for forming multiple glycosidic linkages in solution in a single step are disclosed. The invention takes advantage...
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WO/1994/014827A1 |
Sulfamate derivatives having formula (I), wherein R1, R2, R3, R4, R5 and R6 are as herein defined, have been found to exhibit anticonvulsant activity and are thus useful in the treatment of conditions such as epilepsy. Further, the prese...
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WO/1994/014849A1 |
Highly sulfated oligosaccharides in the form of hexasaccharide and octasaccharide compounds which have antiproliferative activity with respect to smooth muscle cells are useful in treatment of coditions characterized by unwanted smooth m...
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WO/1994/013686A1 |
The invention relates to compounds having a pharmacological activity in the central nervous system, having the capacity of traversing the blood-brain barrier after peripheral administration of said compound, and having the general formul...
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WO/1994/011006A1 |
Substances comprising carboxylated and/or sulfated oligosaccharides in substantially purified form, including compositions containing same and methods of using same, are disclosed for the regulation of cytokine activity in a host. For in...
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WO/1994/007900A1 |
The invention concerns N-glycosylated derivatives of nitrogen nucleophile compounds. The invention also concerns a mild, cost effective, stereoselective, regioselective, and generally applicable method for the preparation of N-glycosides...
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WO/1994/006438A1 |
Nucleoside analogues such as ribofuranosyl-beta-D-pyrrolopyrimidine compounds and ribofuranosyl pyrrolopyrimidine N-oxide compounds and pharmaceutically acceptable salts and mixtures thereof. Compositions comprising these compounds and p...
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WO/1994/002495A1 |
An esterification or amidation process comprises reacting a hydroxylated compound or an organic amine with an oxyacid or its anion capable of accepting a lone pair of electrons. The reaction has the advantage that it is carried out under...
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WO/1994/002624A1 |
An enzymatic process is disclosed for the preparation of galactosylbeta1,3glycal disaccharides such as Galbeta1,3Glucal, an intermediate useful in Lea preparation and an inhibitor of beta-galactosidase. The process utilizes beta-galactos...
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WO/1994/000476A1 |
A method of treating and/or preventing lesion and/or inflammation of non-peptic ulcer nature in the digestive tract of an individual and a method of treating and/or preventing lesion and/or inflammation of the oesophageal, gastric and/or...
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WO/1994/000477A1 |
Compounds and methods of making them having formula (I) are described which bind to selectin receptors and thus modulate the course of inflammation, cancer and related diseases by modulating cell-cell adhesion events. In formula (I), R1 ...
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WO/1994/000596A1 |
A biologically active oligosaccharide compound comprising at least two L hexose rings connected together by an ether oxygen atom. The ether oxygen atom is connected to a first of the rings at the first carbon atom to the right of the hex...
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WO/1993/024506A1 |
Disclosed are novel Lewis?C¿ and LacNAc analogues, pharmaceutical compositions containing such analogues, methods for their preparation and methods for their use.
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WO/1993/024503A1 |
Methods are provided for the sequential removal of monosaccharides from the reducing end of oligosaccharides. The present invention also discloses the use of such methods for structural determinations of oligosaccharides and to enable ne...
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WO/1993/023046A1 |
An enantiomer of a fused ring system compound is disclosed that contains an epoxide group on one side of the fused rings and an enediyne macrocyclic ring on the other side of the fused rings. The enantiomeric compounds have DNA-cleaving,...
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WO/1993/022670A1 |
Methods of providing an image of the gastrointestinal region of a patient and diagnosing the presence of any tumorous tissue in that region using contrast media comprising a combination of at least one polyphosphorylated aliphatic or pol...
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WO/1993/018777A1 |
Mannose-6- and 1-phosphates and their pharmaceutically acceptable salts and bioprecursors thereof are useful in the treatment of fibrotic disorders. They accelerate wound healing and the 6-phosphate prevents or mitigates scar formation. ...
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WO/1993/012778A1 |
A method of inhibiting tissue damage in warm-blooded animals related to reperfusion of tissues after extended periods of ischemia is presented. The method comprises treatment prior to a planned ischemic event or up to six hours after an ...
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WO/1993/010137A1 |
2'-Deoxy-2'-fluorocoformycin and 2'-deoxy-8-epi-2'-fluorocoformycin have now been synthesized by a multistage reaction via 3,5-di-O-benzoyl-2-deoxy-2-fluoro-alpha- and -beta-D-ribofuranosyl bromide. Also 2'-deoxy-2'-epi-2'-fluorocoformyc...
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WO/1993/008205A1 |
This invention contemplates improved methods of enzymatic production of carbohydrates especially fucosylated carbohydrates. Improved syntheses of glycosyl 1- or 2-phosphates using both chemical and enzymatic means are also contemplated. ...
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WO/1993/002091A1 |
Broad spectrum glycosidase inhibitors are produced from monosaccharide lactams by conversion to amidines, amidrazones, or amidoximes. The inhibitors have general formula (I), wherein the N and C are joined as part of a monosaccharide aza...
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WO/1993/001810A1 |
Chimeric analogs of calicheamicin that include an analog of calicheamicinone linked to an ester or glycoside, (-)-calicheamicinone, and intermediates useful in the synthesis of calicheamininone and its analogs are disclosed.
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WO/1992/021688A1 |
Perfluoroalkylated amphiphilic phosphorus compounds, corresponding to formulae (Ia), (Ib) wherein V is O or S; R1, R2 and R3 are H or substituted or unsubstituted perfluoroalkylated or hydrocarbon radicals; provided that R1, R2 or R3 is ...
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WO/1992/021655A2 |
2-Methyl-5-hydroxymethyl- and 2,5-dimethyl-3,4-dihydroxypyrrolidines, their processes of preparation and use are disclosed. 5-Azido-5-deoxy-hexulose-1-phosphate compounds and processes of making the same are also disclosed.
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WO/1992/020823A1 |
Therapeutic oligonucleotide analogs which have improved nuclease resistance and improved cellular uptake are provided. Replacement of phosphorodiester inter-sugar linkages found in wild type oligomers with four atom linking groups forms ...
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WO/1992/020822A1 |
Therapeutic oligonucleotide analogs which have nuclease resistance and improved cellular uptake are provided. Replacement of posphorodiester inter-sugar linkages found in wild type oligomers with four atom linking groups forms unique di-...
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WO/1992/019633A1 |
Certain glycolipids and specific catchers therefor for use in the prophylaxis or therapy of prediabetes, diabetes and/or associated complications and their use respectively for the detection of islet cell antibodies in an individual and ...
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WO/1992/018546A1 |
Highly sulfated oligosaccharides in the form of hexasaccharide and octasaccharide compounds which have antiproliferative activity with respect to smooth muscle cells are useful in treatment of conditions characterized by unwanted smooth ...
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WO/1992/009612A1 |
Glycosyl phosphate triesters are prepared by reacting an anomeric mixture of a substituted hexopyranose with 4-N,N-dimethylaminopyridine and diphenyl chlorophosphate wherein using a specific order of addition determines the stereochemist...
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