Sugars, Derivatives Thereof, Nucleosides, Nucleotides, Nucleic Acids

Matches 301 - 350 out of 829	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >

Document	Document Title
JP7158096B2	Oligosaccharide composition and method for producing same Described herein are methods for the production of oligosaccharides, including functionalized oligosaccharides, from one or more sugars, such as one or more monosaccharides, using polymeric and solid-supported catalysts containing acidic...
JP7077165B2	Method for producing sulfate ester compound To provide a method for producing a sulfate of a hydroxy compound capable of easily producing a sulfate without using special reagents, equipment or reaction conditions and suppressing the decomposition of the hydroxy compound compared w...
JP2021530479A	Enzymatic synthesis of 4'-ethyl nucleoside analogs The present invention eliminates the use of protective groups on intermediates, improves stereoselectivity of glycosylation and reduces the number of process steps required to produce the compound, 4'-ethynyl 2'-deoxy. With respect to th...
JP2021508732A	Glucosamine derivatives to prevent or treat joint disorders Provided are compounds of formula (A) used in the prevention or treatment of joint and bone disorders in mammals, such as arthritis and osteoporosis, as well as pharmaceutically acceptable salts and esters thereof, and pharmaceutical com...
JP2020534361A	Substituted nucleosides, nucleotides, and analogs thereof The compounds of formula (I) and pharmaceutically acceptable salts thereof are disclosed herein. [Chemical 1] The variables in formula (I) are described herein. Methods for synthesizing such compounds, as well as for treating diseases an...
JP6765371B2	Adjuvant The present invention relates to a family of carbohydrate monosulphate fatty acid esters, which contain less than 10 mole % of carbohydrate polysulphate fatty acid esters, and to a method of preparation thereof. The monosulphate carbohyd...
JP6662503B2	Pharmaceuticals Containing Pentosan Polysulfate and Pentosan Polysulfate The present invention provides a pentosan polysulfate having a uronic acid content of 7.0 mass% to 15.0 mass% and an acetyl group content of 0 mass% to 2.0 mass%; a pharmaceutically acceptable salt thereof; or a pharmaceutically acceptab...
JP6595460B2	Use of the drug as a glycan cluster and antibacterial agent A molecule responding to formula (I) of the glycocluster type with galactose residues at their extremities. Simple and efficient methods for the preparation of these compounds. Medical use of compounds (I) as inhibitors of infections by ...
JP6526692B2	A novel synthetic oligomer of Neisseria meningitidis serotype X and its preparation method The present invention relates to synthesis of novel higher oligomers and process of preparing the same. In particular the present invention relates to the chemical synthesis of oligomers of Neisseria meningitidis serogroup X (‘hereinaf...
JPWO2018043667A1	Method for producing acidic xylooligosaccharide and acidic xylooligosaccharide According to the present invention, as a production method in which the cost of acidic xylooligosaccharide is reduced, a step of depolymerizing a plant-derived raw material and a deacetylation step of adjusting the solution of the produc...
JP6339673B2	Methods for Producing Fondaparinux Sodium The present invention provides novel processes for the preparation of Fondaparinux sodium by using the compound of formula ABC5. In some embodiments, the intermediates for the synthesis of Fondaparinux sodium, are also provided.
JP6004586B2	The use as a 3 sugar derivative and an adjuvant The present invention relates to trisaccharide derivates comprising a substituted trisaccharide core, which trisaccharide core is fully substituted with fatty acid ester groups, and optionally one or more anionic groups, to a method for ...
JP5998211B2	The sucrose Octa sulfate ester of magnesium, its manufacturing method, its medicine target, and cosmetics use The invention relates to a sucrose octasulfate of magnesium, having general formula I, the preparation method thereof and the use of same in the pharmaceutical and/or cosmetic field, wherein 0≦n≦4, n is an integer and Y represents OH...
JP5647899B2	Peptide complex glycation using oligosaccharide transferase The current invention provides polypeptides and polypeptide conjugates that include an exogenous N-linked glycosylation sequence. The N-linked glycosylation sequence is preferably a substrate for an oligosaccharyltransferase (e.g., bacte...
JP5643844B2	Manufacturing method of topiramate A process for the preparation of topiramate in an one pot reaction comprises the following steps: A) reacting 2,3:4,5-bis-O-{1-methylethylidene)-β-D-fructopyranose with sulfurylchloride in xylene in the presence of an organic or inorgan...
JP5535202B2	Synthetic analog of phosphatidylumioinositol mannoside with inhibitory activity on inflammatory response The present invention relates to novel synthetic analogs of phosphatidyl-myo-inositol mannosides (hereinafter referred to as PIMs) of general formula (I): or a pharmaceutically acceptable salt thereof, to the method for preparing same an...
JP5484668B2	Synthesis of breast cancer-related antigens identified by the monoclonal antibody MBR1 and their use The present invention provides a process for synthesizing a compound having the structure: ides useful as a vaccine for inducing antibodies to human breast cancer cells in an adjuvant therapy therefor.
JP2014040471A	1'-SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS FOR ANTIVIRAL TREATMENT To provide compounds having activity against infectious Flaviviridae viruses and inhibiting viral RNA-dependent RNA polymerase to have antiviral activity.Provided are substituted carba-nucleoside analogs typically represented by the spec...
JP5425187B2	1'-Substituted Carba-Nucleoside Analogs for Antiviral Treatment Provided are pyrrolo[1,2-f][1,2,4]triazinyl, imidazo[1,5-f][1,2,4]triazinyl, imidazo[1,2-f][1,2,4]triazinyl, and [1,2,4]triazolo[4,3-f][1,2,4]triazinyl nucleosides, nucleoside phosphates and prodrugs thereof, wherein the 1' position of t...
JP2014501730A	Histone inhibition The invention relates to a method of inhibiting the cytotoxic activity of extracellular histones in a subject, comprising administering an effective amount of a polyanion to the subject. In particular the invention relates to a method fo...
JP5389140B2	Heparin-induced polysaccharide mixture, its production and pharmaceutical compositions containing it New mixtures (A) of heparin-derived sulfated polysaccharides have average molecular weight 1500-3000, anti-Xa activity 120-200 IU/mg, anti-IIa activity 0-10 IU/mg and ratio of anti-Xa to anti-IIa activity more than 30; comprise 2-26 sacc...
JP5371167B2	Derivative of partially desulfated glycosaminoglycan having anti-vasculogenic activity and no anticoagulant effect Partially desulfated glycosaminoglycan derivatives are described, particularly heparin, and more particularly formula (I) compounds where the U, R and R1 groups have the meanings indicated in the description. These glycosaminoglycan deri...
JP5314745B2	Manufacture of modified sugars, their conjugates, and shavings Saccharide-protein conjugates having a new type of linker are described. The conjugates comprising the new linker are prepared from modified saccharides comprising a moiety of the formula (I): -A-N(R1)-L-M wherein: A is a bond, —C(O)�...
JP5268222B2	Manufacture of modified sugars, their conjugates, and shavings Saccharide-protein conjugates having a new type of linker are described. The conjugates comprising the new linker are prepared from modified saccharides comprising a moiety of the formula (I): -A-N(R1)-L-M wherein: A is a bond, —C(O)�...
JP2013116856A	AMYLOID β-BINDING MATERIAL AND SENSOR DEVICE USING THE SAME To provide an amyloid β-binding material that excellently binds to an amyloid β, and to provide a sensor device using the same.The present invention relates to an amyloid β-binding material which contains sugar, or a sugar residue der...
JP2013519706A	Methods to prevent cancer metastasis The present invention relates to the use of a specific family of glycerolipid compounds of formula (I) described in the detailed description or the manufacture of a medicament for the prevention or for the treatment of cancer metastasis.
JP5198538B2	Pharmaceutical Compositions and Pharmaceuticals Containing Sulfated Polysaccharides or Sulfated Oligosaccharides It is intended to provide: an analytical method whereby the structure of a sulfated polysaccharide or a sulfated oligosaccharide can be highly sensitively analyzed; a pharmaceutical composition and a drug containing a sulfated polysaccha...
JP5137403B2	Phosphor amidate derivative The present invention provides a phosphoramidate compound having the structure (I) wherein X comprises a monosaccharide group comprising the structure (II) or (III) or a pharmaceutically acceptable salt, ester or salt of such ester. The ...
JP5139797B2	Sulfated oligosaccharide derivative The invention relates to compounds which are polysulfated oligosaccharide derivatives having activity as inhibitors of heparan sulfate-binding proteins and inhibitors of the enzyme heparanase; methods for the preparation of the compounds...
JP5047807B2	Stabilization of radiopharmaceutical precursors The present invention relates to a method for improving stability of non fluoridated sugar derivatives, and in particular glucose derivatives such as 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-ß-D-man nopyranose which are used ...
JP2012188373A	METHOD FOR STEREOSELECTIVELY PRODUCING SUGAR 1-PHOSPHATE DERIVATIVE To provide a means to stereoselectively produce a compound which is composed of a sugar 1-phosphate compound with phosphoric acid bonded to an anomer position (C1 position) thereof (a sugar 1-phosphate compound).A sugar 1-oxazaphospholid...
JP5035940B2	New compounds and methods The present invention provides phosphotetrahydropyran compounds and the use thereof in treating diseases or conditions that are dependent on T-lymphocyte migration, as well as compositions containing said compounds.
JP5021898B2	Heparin-induced polysaccharide mixture, its production and pharmaceutical compositions containing it New mixtures (A) of heparin-derived sulfated polysaccharides have average molecular weight 1500-3000, anti-Xa activity 120-200 IU/mg, anti-IIa activity 0-10 IU/mg and ratio of anti-Xa to anti-IIa activity more than 30; comprise 2-26 sacc...
JP5004261B2	Prophylactic and therapeutic treatment of infections and other diseases with compounds based on monosaccharides and disaccharides Methods for treating infections or autoimmune disease or an allergic condition using monophosphonyl lipid 4 or a mimetic thereof (an aminoalkyl glucosaminide phosphate).
JP5001989B2	Production method of keratan sulfate oligosaccharide fraction A keratan sulfate oligosaccharide which comprises from two to five sugar units and has sulfated N-acetylglucosamine at the reducing end and in a molecule of which at least two hydroxyl groups are sulfated, preferably, which contains at l...
JP4939934B2	Salacinol analogs and methods for their synthesis A method for synthesizing Salacinol, its stereoisomers, and analogues, homologues and other derivatives thereof potentially useful as glycolsidase inhibitors. The compounds of the invention may have the general formula (I) or (II): The s...
JP2012092109A	SYNTHESIS OF THE BREAST TUMOR-ASSOCIATED ANTIGEN IDENTIFIED BY MONOCLONAL ANTIBODY MBR1 AND USE THEREOF To provide new strategies and protocols for oligosaccharide synthesis.There are provided a method for synthesizing a compound having the structure (I) (wherein R is H) and related oligosaccharides useful as a vaccine for inducing antibod...
JP2012509305A	Crystallized pentasaccharides, how to obtain them, and this use for the preparation of Hydraparinax The Invention relates to the methyl pentasaccharide O-2,3,4-tri-O-methyl-α-D-glucopyranosyl-(1→4)-O-2,3-di-O- methyl-β-D-glucopyranosyluronic acid-(1→4)-O-α-D-glucopyranosyl-(1→4)-O-2,3-di-O-méthy l-α-L-idopyranosyluronic acid...
JP4913272B2	Method for producing oligosaccharide and novel oligosaccharide and pharmaceutical composition containing the same
JP2012046511A	PHARMACEUTICAL AGENT CONTAINING LOW MOLECULAR WEIGHT POLYSULFATED HYALURONIC ACID DERIVATIVE To provide a polysulfated hyaluronic acid derivative useful for preventing and/or treating allergic diseases.A low molecular weight polysulfated hyaluronic acid derivative expressed by general formula (IA) or (IB) or a pharmaceutically a...
JP4892191B2	Method for Continuously Producing Fructopyranose Sulfamate Derivatives The present invention is directed to a continuous process for the preparation of fructopyranose sulfamate derivatives of the general formula (I)
JP4838706B2	Predetermined Aminoalkyl Glucosaminide Phosphate Compounds and Their Use Compounds that are adjuvants and immunoeffectors are described and claimed. The compounds augment antibody production in immunized animals as well as stimulate cytokine production and activate macrophages. Compositions and methods for us...
JP2011246481A	CERTAIN AMINOALKYL GLUCOSAMINIDE PHOSPHATE COMPOUND AND USE THEREOF To provide compositions used as adjuvants and immunoeffectors.There are provided certain aminoalkyl glucosaminide phosphate compounds (AGP) represented by formula (I), or pharmaceutically acceptable salts thereof.
JP4810558B2	Phosphorylated sugar and its manufacturing method
JP4806394B2	Method for measuring specific groups constituting heparin or low molecular weight heparin using reverse phase column chromatography The invention provides methods for analyzing heparins, low-molecular-weight heparins, ultralow-molecular-weight heparins, and oligosaccharides by high performance liquid chromatography a stationary phase dynamically coated with a quatern...
JP4755333B2	Polyvalent metal salt compositions of oligosaccharide phosphate and dextrin phosphate and methods for producing them To provide a method for producing a water-soluble composition of bivalent metal salts such as Ca salts of a phosphorylated oligosaccharide (POS) and/or a phosphorylated dextrin (PDN) having excellent filterability without forming precipi...
JP4733329B2	New oligosaccharides, manufacturing methods and pharmaceutical compositions containing them The invention concerns oligosaccharides of formula (I), their mixtures, their diastereomers, methods for preparing them and pharmaceutical compositions containing them.
JP4731477B2	Production of 2-18F-2-deoxy-D-glucose by solid phase synthesis The invention relates to a compound of formula (I): wherein P1, P2, P3, and P4 are each independently hydrogen or a protecting group; and n is an integer of from 2 to 20 and to the use of such compounds for the synthesis of 18F-FDG.
JP4725976B2	Method for producing anticonvulsant derivative of topiramate The present invention is directed to a one-step process for the preparation of fructopyranose sulfamate derivatives of the general formula (I) wherein X, R1, R3, R4, R5 and R6 are as described in the specification.
JP4712001B2	Substituted liposaccharides useful for the treatment and prevention of endotoxemia Novel substituted liposaccharides useful as in the prophylactic and affirmative treatment of endotoxemia including sepsis, septicemia and various forms of septic shock and methods of using these agents are provided. Also provided are met...

Matches 301 - 350 out of 829	< 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 >