Title:
【発明の名称】N―アシルアミノアルキルヒドラジンカルボキシイミダミド類
Document Type and Number:
Japanese Patent JP2000502684
Kind Code:
A
Abstract:
The present invention relates to compositions and methods for inhibiting nonenzymatic cross-linking (protein aging) using compounds of formula (I), wherein alk is a straight or branched chain alkylene group containing from 2 to 8 carbon atoms, and R is a lower alkyl group containing from 1 to 6 carbon atoms; and their biologically or pharmaceutically acceptable acid addition salts. Accordingly, a composition is disclosed which comprises these N-acylaminoalkylhydrazinecarboximidamides, which are capable of inhibiting the formation of advanced glycosylation endproducts of target proteins. The method comprises contacting the target protein with the composition. Both industrial and therapeutic applications for the invention are envisioned, as food spoilage and animal protein aging can be treated.
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Inventors:
Ulric Petersea
Waggle Deep Earl
Waggle Deep Earl
Application Number:
JP52388397A
Publication Date:
March 07, 2000
Filing Date:
December 26, 1996
Export Citation:
Assignee:
Alteon Incorporated
International Classes:
A61K31/155; A61P1/00; A61P1/02; A61P43/00; A61K31/00; C07C281/16; (IPC1-7): C07C281/16; A61P1/02; A61P43/00; A61K31/155
Attorney, Agent or Firm:
Minoru Nakamura (6 outside)