Title:
COMPLEX FORMULATION CONTAINING SUSTAINED RELEASE METFORMIN AND IMMEDIATE RELEASE HMG-COA REDUCTASE INHIBITOR
Document Type and Number:
WIPO Patent Application WO/2015/012633
Kind Code:
A1
Abstract:
The present invention relates to a complex formulation containing metformin used in the treatment of non-insulin dependent diabetes and an HMG-CoA reductase inhibitor used in the treatment of dyslipidemia. The present invention provides a complex formulation and a method for preparing the complex formulation, wherein the complex formulation contains metformin and an HMG-CoA reductase inhibitor, and has effectively improved stability by securing the stable release of respective active ingredients and blocking physical and chemical reactions between the active ingredients.
Inventors:
KANG KWI MAN (KR)
PARK YOUNG JOON (KR)
PARK JUN HONG (KR)
LEE JI EUN (KR)
YOON SEOK KEE (KR)
KIM YU JEONG (KR)
OH TACK OON (KR)
CHO TAE KEUN (KR)
PARK YOUNG JOON (KR)
PARK JUN HONG (KR)
LEE JI EUN (KR)
YOON SEOK KEE (KR)
KIM YU JEONG (KR)
OH TACK OON (KR)
CHO TAE KEUN (KR)
Application Number:
PCT/KR2014/006797
Publication Date:
January 29, 2015
Filing Date:
July 25, 2014
Export Citation:
Assignee:
CJ HEALTHCARE CORP (KR)
International Classes:
A61K9/28; A61K9/20; A61K9/22; A61K31/155
Domestic Patent References:
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Other References:
"Determination of Rosuvastatin in the Presence of Its Degradation Products by a Stability-Indicating LC Method", JOURNAL OF AOAC INTERNATIONAL, vol. 88, no. 4, 2005
"Stability study of cholesterol lowering statin drug in aqueous samples using HPLC and LC-MS", ENVIRON CHEM LETT, vol. 8, 2010, pages 185
See also references of EP 3025708A4
"Stability study of cholesterol lowering statin drug in aqueous samples using HPLC and LC-MS", ENVIRON CHEM LETT, vol. 8, 2010, pages 185
See also references of EP 3025708A4
Attorney, Agent or Firm:
SON, MIN (KR)
손민 (KR)
손민 (KR)
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