Title:
【発明の名称】コルヒチン骨格化合物、それらの医薬としての用途、及びそれらを含有する組成物
Document Type and Number:
Japanese Patent JP2000503669
Kind Code:
A
Abstract:
PCT No. PCT/EP97/02577 Sec. 371 Date Nov. 24, 1998 Sec. 102(e) Date Nov. 24, 1998 PCT Filed May 21, 1997 PCT Pub. No. WO94/47577 PCT Pub. Date Dec. 18, 1997The present invention relates to colchicine and thiocolchicine derivatives which can be obtained from these molecules by functionalization of the C-7 to ketone or functionalization of the amino group. Said compounds have a marked antiblastic activity both on the normal cancer cells and on the chemoresistant phenotype. The compounds of the invention can be administered both by injection and orally.
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Inventors:
Bombardelli, Ezio
Application Number:
JP50110898A
Publication Date:
March 28, 2000
Filing Date:
May 21, 1997
Export Citation:
Assignee:
INDENA S.p.A.
International Classes:
A61K9/127; A61K31/00; A61K31/12; A61K31/122; A61K31/165; A61K31/535; A61P19/00; A61P19/02; A61P29/00; C07D265/36; A61P35/00; C07C49/755; C07C323/22; C07D265/34; C07H15/24; (IPC1-7): C07C49/755; C07D265/36; C07C323/22; A61K31/535; A61K31/12; A61P35/00; A61P29/00; A61P19/02; A61K9/127
Attorney, Agent or Firm:
Hajime Tsukuni (3 outside)