Title:
【発明の名称】縮合ピラゾール化合物
Document Type and Number:
Japanese Patent JP2001512106
Kind Code:
A
Abstract:
Use of a compound which is a condensed pyrazole derivative of formula (I) wherein W is -CONH-, -SO2- or -CO-; X is -O- or -NR4- in which R4 is hydrogen, C1-C6 alkyl, benzyl, pyridyl, tetrahydropyranyl or a phenyl ring, the phenyl ring being unsubstituted or substituted by one or two substituents which are the same or different and are chosen independently from halogen, trifluoromethyl, C1-C6 alkyl, C1-C6 alkoxy, nitro, amino, hydroxy, formylamino, C2-C6 alkanoylamino and C1-C6 alkoxy-carbonyl; each of R, R1, and R2, which are the same or different, is independently hydrogen, halogen, hydroxy, trifluoromethyl, nitro, amino, phenyl, benzyl, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkanoylamino, formylamino or C1-C6 alkoxy-carbonyl; and R3 is hydrogen, or R2 and R3 taken together form a C2-C6 alkylene, -CH=CH-CH= or -O-(CH2)n- chain in which n is 1, 2 or 3; m is zero or an integer of 1 to 6; and Q is C1-C14 alkyl, a phenyl ring or an unsaturated pentatomic heteromonocyclic ring containing two or three heteroatoms which are the same or different and are chosen independently from oxygen, sulphur and nitrogen, wherein the phenyl ring and the heteromonocyclic ring are unsubstituted or substituted by one or two substitutents which are the same or different and are chosen independently from halogen, hydroxy, trifluoromethyl, nitro, amino, phenyl, benzyl, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkanoylamino, formylamino and C1-C6 alkoxy-carbonyl; or a pharmaceutically acceptable salt thereof; in the manufacture of a medicament for use as a kynurenine-3-hydroxylase inhibitor.
Inventors:
Balaji, Mario
Pevaretro, Paolo
Aiden Pergel, Franco
Thoma, Salvatore
SPECIAL, CARMERA
Pevaretro, Paolo
Aiden Pergel, Franco
Thoma, Salvatore
SPECIAL, CARMERA
Application Number:
JP2000505133A
Publication Date:
August 21, 2001
Filing Date:
July 02, 1998
Export Citation:
Assignee:
Farmacia e Appzyon Esset Pear
International Classes:
A61K31/416; A61K31/4162; A61K31/42; A61K31/423; A61K31/424; A61P25/08; A61P43/00; C07D231/54; C07D261/20; C07D491/06; C07D498/06; (IPC1-7): C07D231/54; A61K31/416; A61K31/4162; A61K31/42; A61K31/424; A61P25/08; A61P43/00; C07D261/20; C07D491/06; C07D498/06
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)