Title:
【発明の名称】融合ヘテロ環式化合物及びそのキヌレニン-3-ヒドロキシラーゼ阻害剤としての使用
Document Type and Number:
Japanese Patent JP2001512107
Kind Code:
A
Abstract:
A compound which is a condensed heterocycle of formula (I) wherein a, b and c are all single bonds; or a, b and c are all double bonds; or a is a double bond and b and c are single bonds; m is zero or an integer of 1 to 6; W is -CONH-, -SO2- or -CO-; X is O, S or NR2, in which R2 is hydrogen, C1-C6 alkyl, benzyl, pyridyl, tetrahydropyranyl or a phenyl ring unsubstituted or substituted by one or two substituents which are the same or different and are chosen independently from halogen, C1-C6 alkyl, C1-C6 alkoxy, nitro, amino, hydroxy, formylamino, C2-C6 alkanoylamino trifluoromethyl and C1-C6 alkoxycarbonyl; each of R and R1 is independently hydrogen, halogen, hydroxy, trifluoromethyl, nitro, amino, phenyl, benzyl, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkanoylamino, formylamino or C1-C6 alkoxy-carbonyl; and Q is C1-C14 alkyl or a phenyl ring or an unsaturated pentatomic heteromonocyclic ring containing two or three heteroatoms chosen independently from oxygen, sulphur and nitrogen, wherein the phenyl ring and the heteromonocyclic ring are unsubstituted or substituted by one or two substituents which are the same or different and are chosen independently from halogen, hydroxy, trifluoromethyl, nitro, amino, phenyl, benzyl, C1-C6 alkyl, C1-C6 alkoxy, C2-C6 alkanoylamino, formylamino, and C1-C6 alkoxy-carbonyl, or a pharmaceutically acceptable salts thereof, is useful as a kynurenine-3-hydroxylase inhibitor.
Inventors:
Pevaretro, Paolo
Balaji, Mario
Aiden Pergel, Franco
Greco, Huelicita
Speciale, Carmela
Balaji, Mario
Aiden Pergel, Franco
Greco, Huelicita
Speciale, Carmela
Application Number:
JP2000505134A
Publication Date:
August 21, 2001
Filing Date:
July 02, 1998
Export Citation:
Assignee:
Farmacia e Appzyon Esset Pear
International Classes:
A61K31/416; A61K31/42; A61K31/423; A61K31/425; A61K31/428; A61P25/08; A61P43/00; C07D231/56; C07D261/20; C07D275/04; (IPC1-7): C07D231/56; A61K31/416; A61K31/42; A61K31/425; A61P25/08; A61P43/00; C07D261/20; C07D275/04
Attorney, Agent or Firm:
Yoshio Kawaguchi (2 outside)